Local recurrence after laparoscopic radiofrequency ablation of malignant liver tumors: Results of a contemporary series

Takahashi, Hideo; Akyüz, Muhammet; Aksoy, Erol; Karabulut, Koray; Berber, Eren

doi:10.1002/jso.24599

Cited by 40 publications

(44 citation statements)

References 21 publications

(43 reference statements)

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“…Local recurrence by tumor type (n, total number, %) obtained with RFA, which was 18.4% in our most recent experience. 18 Although these numbers are in line with the results of other recent MWA studies in the literature, [11][12][13][14] it is important to understand the parameters that affect the outcome of liver tumor ablation.…”

Section: Definite Suspicious Overallsupporting

confidence: 73%

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Impact of ablation algorithm versus tumor‐dependent parameters on local control after microwave ablation of malignant liver tumors

Erten

Gökçeimam

et al. 2020

Journal of Surgical Oncology

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Background: The aim of this study is to assess the effect of tumor versus ablationalgorithm dependent parameters on local recurrence (LR) after microwave ablation (MWA) of liver malignancies. Methods: This was an institutional review board-approved study of patients who underwent laparoscopic or open MWA of malignant liver tumors. The impact of ablation algorithm (stepwise or direct heating, single or overlapping ablations, and ablation margin) and tumor-dependent (type, size, location, and blood vessel proximity) parameters on LR was analyzed using Kaplan-Meier and Cox proportional hazards. Results: A total of 179 patients with 602 liver tumors underwent 200 MWA procedures. Colorectal liver metastasis (CLM) was the most frequent tumor type followed by neuroendocrine liver metastasis (NELM), other metastatic tumors, and hepatocellular cancer (HCC). For patients followed at least a year with imaging, LR rate was 8.8% per lesion and 13.1%,1.3%, 11.7%, and 12.6%, for CLM, NELM, HCC, and other tumor types, respectively. On multivariate analysis, independent predictors of LR included tumor type, tumor size, and ablation margin. Conclusion: LR after MWA for malignant liver tumors is predicted by both tumor and surgeon-dependent factors. Variations in the ablation algorithm did not affect LR, leaving the ablation margin as the only parameter that could be modified to optimize local tumor control.

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Section: Definite Suspicious Overallsupporting

confidence: 73%

“…Although it is impossible to know if the latter is an LR or not, we have consistently reported these as LR in previous publications. 15,[17][18][19] When these are accounted as well, it is seen that 82% of the LRs reported in this study were true LRs and 18% suspicious.…”

Section: Definite Suspicious Overallmentioning

confidence: 68%

Impact of ablation algorithm versus tumor‐dependent parameters on local control after microwave ablation of malignant liver tumors

Erten

Gökçeimam

et al. 2020

Journal of Surgical Oncology

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“…After analyzing and comparing the DSA, we concluded that the blood supply characteristics of the metastatic tumor in the same liver were not identical and that a portion of the CRCLM patients would be resistant to chemotherapy, so not every lesion can be controlled well by TACE alone. To achieve a better control of liver metastases, local ablation combined with RFA and CRA is frequently used in our department, and the effectiveness and safety of RFA has been confirmed by some researchers [33,34]. In addition, the use of RFA or CRA is limited in lesions near major bile ducts and great vessels; therefore, the combination of two or more minimally invasive interventional methods to complement the other's advantages may be a necessary strategy.…”

Section: Discussionmentioning

confidence: 98%

Transarterial chemoembolization with raltitrexed-based or floxuridine-based chemotherapy for unresectable colorectal cancer liver metastasis

et al. 2018

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Purpose To evaluate and compare the efficiency and safety of raltitrexed-or floxuridine (FUDR)-based transarterial chemoembolization (TACE) in patients with unresectable colorectal cancer liver metastasis (CRCLM). Methods We conducted a retrospective analysis of 81 patients with unresectable CRCLM who failed systemic chemotherapy and were treated with TACE in our department from Oct 2014 to Oct 2017. Of these, 61 patients received TACE using raltitrexed, oxaliplatin, and pirarubicin (raltitrexed group), and 20 received TACE using FUDR, oxaliplatin, and pirarubicin (FUDR group). The objective response rate (ORR), disease control rate (DCR), overall survival (OS, from the first TACE), progression-free survival (PFS, from the first TACE), and adverse reactions were evaluated and compared between the two groups, and prognostic factors for OS were analyzed. Results The ORRs of the raltitrexed group and FUDR group were 67.2 and 45.0%, respectively (P = 0.076), and the DCRs were 86.9 and 80.0%, respectively (P = 0.452). The median OS (from first TACE) was 14.0 months in the raltitrexed group and 13.0 months in the FUDR group (P = 0.556). The median PFS (from first TACE) was 2.1 months in the raltitrexed group and 2.4 months in the FUDR group (P = 0.878). Univariate and multivariate analyses showed that the primary tumor site, Child-Pugh class, and combination with local ablation (RFA or CRA) were independent significant factors affecting survival. There were no significant differences in adverse reactions between the two groups (P > 0.05), and no treatmentrelated death occurred in either group. Conclusion TACE treatment based on raltitrexed or FUDR is an efficient and safe alternative choice for treating unresectable CRCLM.

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“…Real-time ablation monitoring is necessary to improve the efficiency of the treatment and avoid unwanted risks 2 . While the temperature of the needle probe and tissue impedance monitoring could be of some help in this regard, there exists a need for more accurate ablation monitoring to improve treatment efficiency and to reduce the tumor recurrence 2,3 .…”

Section: Introductionmentioning

confidence: 99%

Monitoring radiofrequency ablation of biological tissue using broadband time-resolved diffuse optical spectroscopy

Lanka

Francis

Kruit

et al. 2019

Diffuse Optical Spectroscopy and Imaging VII

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Radiofrequency ablation (RFA) is minimally invasive thermotherapy, where a heating source is used to target and kill malignant cells in a tissue. While RFA has tremendous potential in the field of oncology, there is also a need for reliable real-time monitoring of this procedure to avoid over or under treatment. In this work, we investigate the use of timeresolved diffuse optical spectroscopy (DOS) to continuously track the change in optical properties during RFA to monitor the process of ablation. The time evolution of the spectra of the optical properties of the tissue undergoing treatment gives deep insights into the structural and constitutional changes occurring during the RFA treatment.

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Local recurrence after laparoscopic radiofrequency ablation of malignant liver tumors: Results of a contemporary series

Cited by 40 publications

References 21 publications

Impact of ablation algorithm versus tumor‐dependent parameters on local control after microwave ablation of malignant liver tumors

Impact of ablation algorithm versus tumor‐dependent parameters on local control after microwave ablation of malignant liver tumors

Transarterial chemoembolization with raltitrexed-based or floxuridine-based chemotherapy for unresectable colorectal cancer liver metastasis

Monitoring radiofrequency ablation of biological tissue using broadband time-resolved diffuse optical spectroscopy

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