Local regulation of corpus luteum development and regression in the cow: Impact of angiogenic and vasoactive factors

Miyamoto, Akio; Shirasuna, Koumei; Sasahara, Kiemi

doi:10.1016/j.domaniend.2009.04.005

Cited by 72 publications

(65 citation statements)

References 79 publications

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“…A high correlation between CL diameter and P4 output was reported in [58,64,81]. However, Adams [4] found a correlation between CL size and P4 serum levels in the early luteal phase only, which could be due to changes in CL vascularity during the cycle, resulting in changes in P4 releasing capacity [46,50]. In our model, the rate of P4 release into the blood is taken as proportional to CL function (Equation 10).…”

Section: Progesteronementioning

confidence: 86%

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A simple mathematical model of the bovine estrous cycle: Follicle development and endocrine interactions

Bôer

Stötzel

Röblitz

et al. 2011

Journal of Theoretical Biology

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Bovine fertility is the subject of extensive research in animal sciences, especially because fertility of dairy cows has declined during the last decades. The regulation of estrus is controlled by the complex interplay of various organs and hormones. Mathematical modeling of the bovine estrous cycle could help in understanding the dynamics of this complex biological system. In this paper we present a mechanistic mathematical model of the bovine estrous cycle that includes the processes of follicle and corpus luteum development and the key hormones that interact to control these processes. The model generates successive estrous cycles of 21 days, with three waves of follicle growth per cycle. The model contains 12 differential equations and 54 parameters. Focus in this paper is on development of the model, but also some simulation results are presented, showing that a set of equations and parameters is obtained that describes the system consistent with empirical knowledge. Even though the majority of the mechanisms that are included in the model are based on relations that in literature have only been described qualitatively (i.e. stimulation and inhibition), the output of the model is surprisingly well in line with empirical data. This model of the bovine estrous cycle could be used as a basis for more elaborate models with the ability to study effects of external manipulations and genetic differences. AMS MSC 2000: 92C42, 92C30, 90C31, 65L09

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Section: Progesteronementioning

confidence: 86%

“…Continued CL growth is stimulated by autocrine and paracrine mechanisms [68]. The CL develops within 2-3 days after ovulation, grows until a maximum diameter of about 30 mm, and starts to regress at day 17-18 of the cycle [50,73], although P4 levels may start to decline earlier [81]. The primary function of the CL is P4 secretion.…”

Section: Corpus Luteummentioning

confidence: 99%

A simple mathematical model of the bovine estrous cycle: Follicle development and endocrine interactions

Bôer

Stötzel

Röblitz

et al. 2011

Journal of Theoretical Biology

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“…During physiological luteolysis in cattle, PGF 2a is released from the endometrium as well as the CL (Shirasuna et al 2004). Furthermore, gene expressions of steroidogenic, angiogenic, and vasoactive factors in luteal tissue provided relevant information regarding functionality of the bovine CL (Miyamoto et al 2009, Shirasuna et al 2010. The proinflammatory cytokine TNFA is present in bovine luteal cells, as well as in immune cells (mainly macrophages; Sakumoto et al 2011), and is capable of reducing P 4 secretion, increasing PGF 2a production, and inducing apoptosis in luteal cell cultures (Okuda & Sakumoto 2003, Skarzynski et al 2005.…”

Section: Introductionmentioning

confidence: 99%

Lipopolysaccharide enhances apoptosis of corpus luteum in isolated perfused bovine ovaries in vitro

Lüttgenau¹,

Möller²,

Kradolfer³

et al. 2016

Reproduction

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Lipopolysaccharide (LPS), the endotoxin of Gram-negative bacteria, has detrimental effects on the structure and function of bovine corpus luteum (CL) in vivo. The objective was to investigate whether these effects were mediated directly by LPS or via LPS-induced release of PGF 2a . Bovine ovaries with a mid-cycle CL were collected immediately after slaughter and isolated perfused for 240 min. After 60 min of equilibration, LPS (0.5 mg/ml) was added to the medium of five ovaries, whereas an additional six ovaries were not treated with LPS (control). After 210 min of perfusion, all ovaries were treated with 500 iu of hCG. In the effluent perfusate, concentrations of progesterone (P 4 ) and PGF 2a were measured every 10 and 30 min, respectively. Punch biopsies of the CL were collected every 60 min and used for RT-qPCR to evaluate mRNA expression of receptors for LPS (TLR2, -4) and LH (LHCGR); the cytokine TNFA; steroidogenic (STAR, HSD3B), angiogenic (VEGFA 121 , FGF2), and vasoactive (EDN1) factors; and factors of prostaglandin synthesis (PGES, PGFS, PTGFR) and apoptosis (CASP3, -8, -9). Treatment with LPS abolished the hCG-induced increase in P 4 (P%0.05); however, there was a tendency (PZ0.10) for increased release of PGF 2a at 70 min after LPS challenge. Furthermore, mRNA abundance of TLR2, TNFA, CASP3, CASP8, PGES, PGFS, and VEGFA 121 increased (P%0.05) after LPS treatment, whereas all other factors remained unchanged (PO0.05).In conclusion, reduced P 4 responsiveness to hCG in LPS-treated ovaries in vitro was not due to reduced steroidogenesis, but was attributed to enhanced apoptosis. However, an impact of luteal PGF 2a could not be excluded.

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“…Other cytokines such as TNFα, IL6 and IL1β (Paula- Lopes et al, 1999) are not dependent on steroidal hormones, being expressed throughout the oestrous cycle. Although we did neither assess P4 concentrations at Day 4 nor at Day 7, the uterine environment in metoestrus (Day 4) or early dioestrus (Day 7) is regulated by rising concentrations of P4 secreted from the CL (Beltman et al, 2009a, Miyamoto et al, 2009, Forde et al, 2011a .…”

Section: Discussionmentioning

confidence: 99%

“…Within the CL, PGF2α suppress the expression of angiogenic factors such as vascular epithelial growth factor (VEGF) and increase the expression of vasoactive factors such as endothelin-1 (EDN1), angiotensin II (ANG II) and luteal PGF2α (Miyamoto et al, 2005), that produce a vasoconstriction decreasing luteal blood flow, and results in initiation of luteolysis (Miyamoto et al, 2009, Berisha et al, 2010, Scully et al, 2015.…”

Section: Bovine Oestrous Cyclementioning

confidence: 99%

63 Effect of Endometrial Biopsy on Uterine Health of Tropically Adapted Beef Cattle

Ramirez-Garzon

Satake

Lyons

et al. 2017

Reprod. Fertil. Dev.

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In cattle, early embryonic loss during the first two to three weeks after fertilisation is recognised as the major cause of reproductive failure, with consequent significant impacts on business performance of beef and dairy farms. Inadequate endometrial receptivity is considered an important cause of early embryonic mortality in cattle. A pilot experiment was conducted to compare the outcome of performing different endometrial sampling procedures in tropically adapted (Bos indicus x Bos taurus) heifers, and to select the most suitable method to collect samples for investigation of endometrial gene expression. Endometrial biopsy (EB) using a biopsy device with a diameter similar to an artificial insemination gun (10366L Karl Storz®, Germany) was found to be the most reliable method of collecting endometrial samples in these heifers, with the samples recovered yielding a mean concentration of RNA of 72.9 ±39.3 ng/µl and mean RNA integrity number (RIN) of 7.3 ±1.1.To assess the likely safety of conducting EB in cattle a systematic review of published information assessing the impact of EB on subsequent pregnancy rates was conducted. Using the Preferred Reporting Items for Systematic reviews and Meta-Analysis (PRISMA) protocol, online searches identified 1164 possible studies. After applying the exclusion criteria, six studies allowed the comparison of pregnancy rates between sampled (n= 1,208) and non-sampled cows (n=2,393). The results showed that EB can be performed before breeding without adversely affecting the likelihood of cows becoming pregnant.A major objective of the research was to determine whether EB and evaluation of endometrial gene expression could be used to identify tropically adapted embryo transfer (ET) recipients more likely to become pregnant. Three potential EB scenarios were investigated, 1) EB on Day 7 of the oestrous cycle prior to the cycle when ET would be performed, 2) EB on Day 4 of the oestrous cycle in which ET would be performed i.e. EB 3 days before ET, and 3) EB on the same day when ET would be performed.The first study assessed the morphological and inflammatory changes induced by endometrial biopsy. Pre-synchronised heifers underwent EB from the horn ipsilateral to the corpus luteum (CL) either at Day 7 of the previous cycle (Group 1 n=10) followed by administration of a luteolytic dose of prostaglandin F2α or at Day 4 (Group 2, n=7) of the present cycle. All heifers were slaughtered on Day 7 of the present cycle. The site of EB was visually evident in 40% (4/10) of Group 1 and 42% (3/7) of Group 2 heifers. Histological assessment revealed no evidence of changes indicative of endometritis in either the biopsied or non-biopsied horns in both groups. The histological iii changes observed included mild mononuclear infiltration of the epithelium and mild vascular changes associated with haemorrhage and congestion.Initial investigation of the endometrial expression of the pro-inflammatory cytokine IL1β and wound healing cytokine TGFβ genes found no significant difference betwe...

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Local regulation of corpus luteum development and regression in the cow: Impact of angiogenic and vasoactive factors

Cited by 72 publications

References 79 publications

A simple mathematical model of the bovine estrous cycle: Follicle development and endocrine interactions

A simple mathematical model of the bovine estrous cycle: Follicle development and endocrine interactions

Lipopolysaccharide enhances apoptosis of corpus luteum in isolated perfused bovine ovaries in vitro

63 Effect of Endometrial Biopsy on Uterine Health of Tropically Adapted Beef Cattle

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