Local release and isolation of circulating tumor cells captured by the nano-morphologic substrate coated with gelatin under near-infrared light

Recent advances in photothermal nanomaterials-mediated detection of circulating tumor cells

“…The substrate was coated with gelatin lms doped with gold nanorods and could be used to capture and detect CTC by exploiting the temperature-sensitive properties of gelatin and the photothermal effect of GNR, and the captured cells could be released under NIR illumination. 73 3.2.2 Gold nanospheres. Another gold nanostructure is gold nanospheres, which have received a lot of attention as photothermal therapeutic particles due to their excellent biocompatibility, chemical stability and ease of synthesis, and their ability to convert absorbed light energy into heat by having strong absorption tunable in the near-infrared region -shell structure.…”

“…The substrate was coated with gelatin films doped with gold nanorods and could be used to capture and detect CTC by exploiting the temperature-sensitive properties of gelatin and the photothermal effect of GNR, and the captured cells could be released under NIR illumination. 73 …”

Progress in Gelatin as Biomaterial for Tissue Engineering

“…Entrapped cells, afterwards, are released steadily from the platform owing to the ability of gelatin to respond to physical stimuli (such as temperature). This gelatin-based platform allows for cancer cell isolation and posterior analysis as well as ensuring the encapsulated cells' viability at all times, as a result of the biocompatibility provided by this biomaterial [117,118]. This novel system that traps cells and allows analyzing them in detail is a significant breakthrough in personalized medicine, as it would allow accurate diagnosis together with specific treatments for each case of tumor.…”

Recent progress of nanostructure-based enrichment of circulating tumor cells and downstream analysis

“…Fan et al coated a layer of gelatin film doped with gold nanorods on the TiO 2 nanorod substrate to achieve the efficient capture of CTCs and photocontrolled release in response to near-infrared light. 105 By adjusting the size and position of near-infrared light, selected cells can be locally released, while gelatin has good biocompatibility and low near-infrared phototoxicity so that the cells released by this method have high vitality.…”