Local release of metalloproteinases and their inhibitors after a successful revascularisation procedure

Grande, Raffaele; Brachini, Gioia; Sterpetti, Antonio V.; Borrelli, Valeria; Serra, Raffaele; Pugliese, Francesco; D'Ermo, Giuseppe; Tartaglia, Elvira; Rubino, Paolo; Mingoli, Andrea; Sapienza, Paolo

doi:10.1111/iwj.13249

Cited by 3 publications

(1 citation statement)

References 44 publications

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“…Patients with diabetes and critical limb ischaemia (CLI) are chronic generally, and their history is often characterised by numerous hospitalisations for frequent complications such as infection, neuropathy (chronic severe pain), and foot ulceration 1 . Recently we showed the pivotal role of negative pressure wound therapy (NPWT) and different moisture dressings as advanced adjuvant therapy after adequate revascularisation 2 in patients with CLI 2‐5 ; moreover, several authors 6 showed that autologous platelet‐rich plasma (PRP) applied in patients with diabetes and CLI undergoing minor amputation can be effective to improve wound healing. In other important work, they also showed that PRP associated to skin graft procedures can be effective to speed up the healing rate of non‐healing ulcers 7,8 .…”

Section: Introductionmentioning

confidence: 99%

A multistage combined approach to promote diabetic wound healing in COVID‐19 era

Grande

Fiori

Russo

et al. 2020

International Wound Journal

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When diabetes mellitus is not properly controlled with drugs and a healthy lifestyle, it exposes patients with advanced peripheral arterial disease or critical limb ischaemia (CLI) to the most serious complications, in particular lower limb ulcers. Surgical or endovascular treatments represent the first line of intervention; in addition, the adequate management of ulcers can guarantee not only a faster wound healing but also the improvement of the patient's prognosis. To speed up this process, negative pressure wound therapy (NPWT), platelet‐rich plasma (PRP), and other advanced moist wound dressing have been proposed. During Coronavirus disease 2019 (COVID‐19) pandemic, many patients with CLI and diabetes mellitus had difficult access to advanced treatments with a significant reduction in life expectancy. We report the cases of patients with non‐healing ulcers and CLI treated with an empiric multistage approach after successful endovascular revascularisation; the postoperative course was eventful in all patients, and foot ulcers are currently in an advanced state of healing. The association between adequate revascularisation, systemic anti‐inflammatory, and antibiotic therapy with the multistage advanced medications ensures healing of ulcers, limb salvage, and improvement of patient prognosis.

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Section: Introductionmentioning

confidence: 99%

A multistage combined approach to promote diabetic wound healing in COVID‐19 era

Grande

Fiori

Russo

et al. 2020

International Wound Journal

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Wound fluid sampling methods for proteomic studies: A scoping review

Harvey

Mellody

Cullum

et al. 2022

Wound Repair Regeneration

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Understanding why some wounds are hard to heal is important for improving care and developing more effective treatments. The method of sample collection used is an integral step in the research process and thus may affect the results obtained. The primary objective of this study was to summarise and map the methods currently used to sample wound fluid for protein profiling and analysis. Eligible studies were those that used a sampling method to collect wound fluid from any human wound for analysis of proteins. A search for eligible studies was performed using MEDLINE, Embase and CINAHL Plus in May 2020. All references were screened for eligibility by one reviewer, followed by discussion and consensus with a second reviewer.Quantitative data were mapped and visualised using appropriate software and summarised via a narrative summary. After screening, 280 studies were included in this review. The most commonly used group of wound fluid collection methods were vacuum, drainage or use of other external devices, with surgical wounds being the most common sample source. Other frequently used collection methods were extraction from absorbent materials, collection beneath an occlusive dressing and direct collection of wound fluid. This scoping review highlights the variety of methods used for wound fluid collection. Many studies had small sample sizes and short sample collection periods; these weaknesses have hampered the discovery and validation of novel biomarkers. Future research should aim to assess the reproducibility and feasibility of sampling and analytical methods for use in larger longitudinal studies.

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Novel Biomarkers in Cardiovascular Surgery

et al. 2021

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Cardiovascular disease includes health problems related to the heart, arteries and veins and is a significant healthcare problem worldwide. Cardiovascular disease may be acute or chronic and relapses are frequent. Biomarkers involved in this field may help clinicians and surgeons in diagnosis and adequate decision making. Relevant articles searched in the following databases Medline, Scopus, ScienceDirect, were retrieved and analysed. Several biomarkers have been identified and we analyzed those of most importance from a clinical and surgical point of view. Biomarkers can better identify high-risk individuals, facilitate follow-up process, provide information regarding prognosis and better tailor the most appropriate surgical treatment.

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Local release of metalloproteinases and their inhibitors after a successful revascularisation procedure

Cited by 3 publications

References 44 publications

A multistage combined approach to promote diabetic wound healing in COVID‐19 era

A multistage combined approach to promote diabetic wound healing in COVID‐19 era

Wound fluid sampling methods for proteomic studies: A scoping review

Novel Biomarkers in Cardiovascular Surgery

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