The resistance loss and energy consumption when fluid flows through a tee in an HVAC system are severe. To improve energy efficiency and reduce carbon emissions, a novel tee with a U-shaped deflector is proposed, supported by experiments and numerical simulations. The resistance reduction mechanism of the U-shaped deflector was analyzed according to the viscous dissipation principle and the field synergy principle. The resistance reduction of the novel tee with different deflector angles and a traditional tee were compared. The results show that the resistance loss of the tee was mainly due to the flow separation and deformation of the fluid in the main branch. The relationship between the local resistance coefficient and the diameter ratio of the main-branch pipe was exponential, and the relationship between the local resistance coefficient and the diameter ratio of the main straight pipe was linear. The total resistance loss reduction rate of the tee with the addition of a 26° deflector was the highest, reaching 72.4%, the volume-weighted average synergy angle increased by 1°, and the viscous dissipation decreased by 21.7%. This study provides a reference for the resistance reduction design of complex local components such as tees in HVAC systems.