Local Sensitivity Analysis of a Closed-Loop in Silico Model of the Human Baroregulation

Tlałka, Karolina; Saxton, Harry; Halliday, Ian; Xu, Xu; Taylor, Daniel; Narracott, Andrew; Malawski, Maciej

doi:10.1007/978-3-031-63772-8_17

Lecture Notes in Computer Science

2024

DOI: 10.1007/978-3-031-63772-8_17

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Local Sensitivity Analysis of a Closed-Loop in Silico Model of the Human Baroregulation

Karolina Tlałka,

Harry Saxton,

Ian Halliday

et al.

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2024

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Cited by 1 publication

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Sensitivity analysis of closed-loop one-chamber and four-chamber models with baroreflex

Tlałka,

Saxton,

Halliday

et al. 2024

PLoS Comput Biol

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The baroreflex is one of the most important control mechanisms in the human cardiovascular system. This work utilises a closed-loop in silico model of baroreflex regulation, coupled to pulsatile mechanical models with (i) one heart chamber and 36-parameters and (ii) four chambers and 51 parameters. We perform the first global sensitivity analysis of these closed-loop systems which considers both cardiovascular and baroreflex parameters, and compare the models with their respective unregulated equivalents. Results show the reduced influence of regulated parameters compared to unregulated equivalents and that, in the physiological resting state, model outputs (pressures, heart rate, cardiac output etc.) are most sensitive to parasympathetic arc parameters. This work provides insight into the effects of regulation and model input parameter influence on clinical metrics, and constitutes a first step to understanding the role of regulation in models for personalised healthcare.

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Sensitivity analysis of closed-loop one-chamber and four-chamber models with baroreflex

Tlałka,

Saxton,

Halliday

et al. 2024

PLoS Comput Biol

View full text Add to dashboard Cite

show abstract

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Local Sensitivity Analysis of a Closed-Loop in Silico Model of the Human Baroregulation

Cited by 1 publication

References 19 publications

Sensitivity analysis of closed-loop one-chamber and four-chamber models with baroreflex

Sensitivity analysis of closed-loop one-chamber and four-chamber models with baroreflex

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