Local Shear Stress and Brachial Artery Functions in End-Stage Renal Disease

Verbeke, Francis; Agharazii, Mohsen; Boutouyrie, Pierre; Pannier, Bruno; Guérin, Alain P.; London, Gérard M.

doi:10.1681/asn.2006040400

Cited by 60 publications

(67 citation statements)

References 33 publications

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“…On the arm opposite to the arteriovenous shunt, brachial artery (BA) internal diameter, stroke diameter changes, BA wall-intima-media thickness (IMT), and SR were independently measured with a high-resolution B-mode (7.5-MHz transducer) echotracking system (Wall-Track System, PIE Medical, Maastricht, the Netherlands), as described previously in detail (13)(14)(15)(16). Briefly, vessel walls are identified automatically and their displacement is tracked throughout the cardiac cycle.…”

Section: Brachial Artery Hemodynamic Measurementsmentioning

confidence: 99%

“…BA distensibility was determined from pulse pressure (PP) change and from BA diameter changes (⌬BA), Dd ϭ Ds -Dd, where Ds is the systolic and Dd the diastolic BA diameter, according to following formula: BA distensibility (kPa -1 x 10 -3 ) ϭ 2[(Ds -Dd)/Dd]/PP (17). The BA incremental elastic modulus (Einc) was determined according to the previously reported formula (16,17): Einc ϭ [(BA lumen cross-sectional area/BA-wall cross-sectional area ϩ 1)ϫ3)]/BA distensibility. SR was measured with the same device but with different settings, as previously reported (13)(14)(15)(16).…”

Section: Brachial Artery Hemodynamic Measurementsmentioning

confidence: 99%

“…The BA incremental elastic modulus (Einc) was determined according to the previously reported formula (16,17): Einc ϭ [(BA lumen cross-sectional area/BA-wall cross-sectional area ϩ 1)ϫ3)]/BA distensibility. SR was measured with the same device but with different settings, as previously reported (13)(14)(15)(16). The echo system is shifted to pulsed Doppler mode and a 30°oblique radiofrequency line is digitized at high frequency (24 MHz).…”

Section: Brachial Artery Hemodynamic Measurementsmentioning

confidence: 99%

“…Because recommended hemoglobin levels should be maintained within 100 to 120 g/L, the progressive ⌬SS was obtained by modifying SR. After 10 minutes, the gloveprotected hand was introduced into a water-filled thermocontrolled device (Polystat 1, Bioblock Scientific, Illkirch, France) (14,16,18). The arm was positioned and immobilized in an inflatable splint.…”

Section: Hand-warming Protocolmentioning

confidence: 99%

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Flow-Mediated Vasodilation in End-Stage Renal Disease

Verbeke

Pannier²,

Guérin³

et al. 2011

Clinical Journal of the American Society of Nephrology

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SummaryBackground and objectives An intact endothelium is essential for adaptations between arterial vasomotor tone and shear stress (SS), i.e., flow-mediated vasodilation (FMD). Endothelial dysfunction occurs in hypertension, cardiac insufficiency, diabetes, atherosclerosis, and in end-stage renal disease (ESRD) patients, whose renal failure is associated with many of those cardiovascular diseases (CVD).Design, setting, participants, & measurements Using a progressive hand-warming protocol and repeated measures ANOVA, we analyzed SS-mediated increase of brachial artery diameter (⌬BA) in 22 healthy controls, 18 CVD-negative ESRD patients (ESRD-CVD Ϫ ), and 17 CVD-positive ESRD patients (ESRD-CVD ϩ ) to analyze the role of uremia versus CVD on FMD.Results Hand-warming increased SS (P Ͻ 0.001) and ⌬BA (P Ͻ 0.001). Negative interactions were observed between ⌬BA and ESRD (P Ͻ 0.001), and between ⌬BA and CVD ؉ (P Ͻ 0.02), but there was no interaction between ESRD and CVD ϩ (P ϭ 0.69). For low and mild SS increases, ESRD-CVD Ϫ patients were characterized by similar ⌬BA as controls, but it was lower than controls at higher SS (P Ͻ 0.01). In ESRD-CVD ϩ patients, brachial artery diameter did not respond to mild and moderate SS increases, and showed "paradoxical" vasoconstriction at higher SS (P Ͻ 0.05). In ESRD, a positive and independent interaction was observed between ⌬BA and 25(OH) vitamin D 3 insufficiency (Յ15 g/L; P Ͻ 0.02). ConclusionsThese observations indicate that, independently of each other, ESRD and CVD ϩ history are associated with endothelial dysfunction. They also suggest the importance of considering the relationships between SS and endothelial function in different clinical conditions.

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Section: Brachial Artery Hemodynamic Measurementsmentioning

confidence: 99%

Section: Brachial Artery Hemodynamic Measurementsmentioning

confidence: 99%

Section: Brachial Artery Hemodynamic Measurementsmentioning

confidence: 99%

Section: Hand-warming Protocolmentioning

confidence: 99%

See 2 more Smart Citations

Flow-Mediated Vasodilation in End-Stage Renal Disease

Verbeke

Pannier²,

Guérin³

et al. 2011

Clinical Journal of the American Society of Nephrology

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“…[7][8][9][10] In association with anemia-related low whole blood viscosity (WBV), SS is reduced in patients with end-stage renal disease (ESRD), 11 and this abnormality is associated with arterial outward remodelling, increased arterial stiffness, and reduced flow-mediated dilation. 12 Increased SS because of partial anemia correction was associated with reduced arterial stiffness and improved flow-mediated dilation. 12 Plasma levels of endothelial MPs in patients with ESRD predict the severity of these arterial and endothelial dysfunctions independent of other classical risk factors, 5 but the eventual role of SS alterations on the in vivo formation and release of MPs by endothelial cells remains unknown.…”

mentioning

confidence: 97%

In Vivo Shear Stress Determines Circulating Levels of Endothelial Microparticles in End-Stage Renal Disease

et al. 2007

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Abstract-Shear stress is a major determinant of endothelial apoptosis, but its role in the in vivo release of shed membrane microparticles by endothelial cells remains unknown. Thus, we sought to evaluate the possible relationship between circulating endothelial microparticle levels and laminar shear stress in end-stage renal disease patients with high cardiovascular risk, whose levels of endothelial microparticles are elevated. In 34 hemodialyzed patients, we analyzed the relationships between brachial artery and aortic shear stress and circulating microparticles levels. Only endothelial microparticles were inversely correlated with laminar shear stress values (PϽ0.0001) or its components shear rate and whole blood viscosity, independent of age or arterial blood pressure. Changes in hematocrit resulting from hemodialysis-induced hemoconcentration or erythropoietin anemia improvement induced a significant increase in whole blood viscosity and shear stress and were associated with a significant decrease in endothelial microparticles with a significant and inverse correlation with changes in hematocrit/hemoglobin or laminar shear stress. These results demonstrate that, in end-stage renal disease patients, laminar shear stress is an important determinant of plasma levels of endothelial microparticles. Anemia as an important determinant of whole blood viscosity and shear stress, contributes to endothelial apoptosis, and could play an indirect role in the pathogenesis of accelerated arteriosclerosis in this high-risk population.

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