Local side‐effects during 4‐year treatment with inhaled corticosteroids – a com between pressurized metered‐dose in and Turbuhaler®

Selroos, Olof; Backman, Ruth; Forsén, Kent; Löfroos, A B; Niemistö, M; Pietinalho, Anne; Äikäs, C.; Riska, Henrik

doi:10.1111/j.1398-9995.1994.tb00794.x

Cited by 68 publications

(40 citation statements)

References 9 publications

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“…Holding chambers and spacers are used to decrease the oropharyngeal deposition from a P-MDI, in order to avoid local side-effects such as hoarseness and oropharyngeal candidiasis. In a recent study in 154 patients using a steroid P-MDI with spacer, the frequency of local side-effects, mainly hoarseness, was reduced from 21 to 6% when transferring from P-MDI to budesonide via Turbuhaler® [12].…”

Section: Discussionmentioning

confidence: 98%

Lung deposition of budesonide from Turbuhaler is twice that from a pressurized metered-dose inhaler P-MDI

Thorsson¹,

Edsbäcker²,

Conradson³

1994

Eur Respir J

375

167

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L Lu un ng g d de ep po os si it ti io on n o of f b bu ud de es so on ni id de e f fr ro om m T Tu ur rb bu uh ha al le er r¤ ¤ i is s t tw wi ic ce e t th ha atABSTRACT: The pulmonary and systemic availability of budesonide after inhalation from a dry powder inhaler, Turbuhaler®, and from a pressurized metered-dose inhaler (P-MDI) were compared in healthy volunteers. Two different methods were used to assess pulmonary availability: 1) calculated from the systemic availability corrected for an oral availability of 13% (n=24); and 2) after blocking of gastrointestinal absorption by administration of a charcoal suspension (n=13). An intravenous infusion of budesonide was used as a reference.The systemic availability of budesonide, calculated as a geometric mean and expressed as percentage of the metered dose, was 38% for Turbuhaler® and 26% for P-MDI. The pulmonary availability, calculated using the first method, was 32% and 15% for Turbuhaler® and P-MDI, respectively; and, using the second method, 32% and 18%, respectively.The results of the present study indicate that administration of budesonide via Turbuhaler® gives rise to a lung deposition which is approximately twice that of a P-MDI, with less variability, but that systemic availability is only increased by approximately 50%. Thus, the present data suggest that by administrating budesonide via Turbuhaler®, instead of a P-MDI, the same degree of asthma control can be achieved with a lower dose, which, in turn, reduces the risk of undesired systemic effects.

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Section: Discussionmentioning

confidence: 98%

Lung deposition of budesonide from Turbuhaler is twice that from a pressurized metered-dose inhaler P-MDI

Thorsson¹,

Edsbäcker²,

Conradson³

1994

Eur Respir J

375

167

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“…In the last meeting in our study, the oral evaluation score average of the study group was found to be better than the control group. In a study by Selroos et al (24), which examined the local side effects of inhaler corticosteroids during 4 years of treatment by comparing metered dose inhalers and turbuhaler devices, patients using both devices were told to rinse their mouths with water after inhalation. It was reported that the incidence of local side effects such as candidiasis or hoarseness of voice in patients using a metered dose inhaler reduced from 21% to 6% and there were no side effects in patients using a turbuhaler.…”

Section: Discussionmentioning

confidence: 99%

The Effect of a Training Program on Oral Health and Behavior Change in Asthma Patients

et al. 2016

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Background: Asthma is a chronic disease which is prevalent throughout the world. Physical problems such as deterioration in oral health, which may occur due to the triggering factors of asthma as well as the ineffective use of asthma medicine, seem to affect the daily lives of asthma patients. Therefore, it is important to protect oral health and promote positive behavior changes in asthma patients in order to achieve effective treatment and asthma control. Aims: The present study aimed to determine the effects of a training program provided for asthma patients on oral health, inhaler use skills, and behavior change. Study Design: Controlled experimental study. Methods: A total of 124 asthma patients were included in the study. Of the patients, 62 were assigned to the experimental group and the other 62 were assigned to the control group. Data were collected using the patient identification form, the oral assessment guide, the inhaler use skill form, and the evaluation form for behavior change over time. The experimental group received training provided by the researchers on the first meeting and one month later. Written and visual training material were used. Both groups were subject to a final evaluation which was conducted 4 months after their first meeting. Results: It was determined that the oral assessment guide scores (p<0.01) and inhaler use skills of the experimental group improved significantly after the training compared to the control group (p<0.01). In addition, it was observed that the number of patients in the experimental group who quit smoking (p<0.05), used their medicine (p<0.01) and brushed their teeth on a regular basis (p<0.01), and washed their mouth after inhaler use significantly increased in the experimental group after training compared to the control group (p<0.01). Conclusion:The study demonstrated that the training provided for asthma patients improved oral health and promoted inhaler use skills and was partially effective in promoting positive asthma-related behavior change.

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“…Развитие дисфонии зависит от дозы иГКС и чаще встречается у лиц с повышен-ной голосовой нагрузкой. В некоторых исследовани-ях показано, что при приеме иГКС с помощью ДПИ снижается частота развития дисфонии, что, возмож-но, обусловлено разной позицией голосовых связок при использовании ДПИ и ДАИ [11]. Лечение дис-фонии заключается в соблюдении голосового режи-ма, сокращении дозы иГКС до минимально необхо-димой для контроля над БА, использовании ДПИ или применении иГКС, являющихся пролекарством (БДП, циклесонид).…”

Section: нежелательные эффекты игксunclassified

Safety of Inhaled Corticosteroids in the Therapy of Bronchial Asthma

Ненашева¹

2014

Pulʹmonologiâ (Mosk.)

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Local side‐effects during 4‐year treatment with inhaled corticosteroids – a com between pressurized metered‐dose in and Turbuhaler®

Cited by 68 publications

References 9 publications

Lung deposition of budesonide from Turbuhaler is twice that from a pressurized metered-dose inhaler P-MDI

Lung deposition of budesonide from Turbuhaler is twice that from a pressurized metered-dose inhaler P-MDI

The Effect of a Training Program on Oral Health and Behavior Change in Asthma Patients

Safety of Inhaled Corticosteroids in the Therapy of Bronchial Asthma

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