Local Targeted Memory Reactivation in Human Sleep

Bar, Ella; Marmelshtein, Amit; Arzi, Anat; Perl, Ofer; Livne, Ethan; Hizmi, Eyal; Paz, Rony; Sobel, Noam; Dudai, Yadin; Nir, Yuval

doi:10.1016/j.cub.2020.01.091

Cited by 41 publications

(39 citation statements)

References 83 publications

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“…Simultaneously, activity levels in the parasympathetic nervous system and related functions increased. In a state of deep relaxation, participants' energy consumption decreased, which increased the myoglobin level and oxygen-carrying capacity of the blood, leading to a high blood oxygen level in the brain, which was conducive to brain tissue reconstruction (Bar et al, 2020;Laventure et al, 2016). Tactile sensations are mainly responsible for transmitting varying sensory information to the central nervous system, which transmits the information to the relevant brain areas (Berkheimer et al, 2017).…”

Section: Pre-and Postintervention Scores Of Ms and Av Groups For Rbmt...mentioning

confidence: 99%

Chemo Checker: Transforming Care and Increasing Patient Safety by Reducing Nurse Distractions

Adams

Waldo

Brodie

et al. 2022

CJON

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BREAST CANCER IS CAUSED BY ABNORMAL PROLIFERATION of breast epithelial tissue cells that cause malignant transformation, and its incidence has risen steadily (Zeng et al., 2017). Chemotherapy is commonly used pre-and postsurgery for patients with breast cancer, and the chemotherapy regimens are mainly based on anthracyclines (Li et al., 2018). Patients often experience reduced quality of life (QOL) from adverse side effects. Therefore, postoperative nursing care for this population has gained increased attention.Chemotherapy-related cognitive impairment (CRCI), sometimes known as "chemobrain," is a common side effect and an issue in patients with breast cancer (Kovalchuk et al., 2017). CRCI clinically manifests as verbal memory decline, information processing speed decrease, confusion of thinking, and the decline of executive function and visuospatial ability (Bompaire et al., 2017). Kaiser et al. (2014) found that 14%-85% of patients experienced deficits in attention, memory, executive control, and handling speed of life events following chemotherapy. Chemotherapy also led to a progressive decline in cognitive functioning in patients with breast cancer, with peak decline occurring during cycles 3-5 (Lange et al., 2019). CRCI substantially affects patients' short-and long-term recovery and QOL. Memory dysfunction is an initial symptom of CRCI (Nott & Glass, 2018) and can trigger mental disorders, including depression and anxiety, which affects patients' recovery and QOL. Kesler et al. (2013) tested a computerized cognitive training program for breast cancer survivors receiving chemotherapy, finding significant improvements in memory and attention. Other studies demonstrated therapeutic effects of audiovisual training on cognitive functioning recovery among patients who had a stroke (Chen & Mao, 2016; Zhang, Chen, et al., 2016). The authors of the current study developed a multisensory stimulation training program that consists of visual, auditory, tactile, and olfactory training techniques to attenuate CRCI and executive dysfunction in patients with breast cancer receiving chemotherapy. The results provide a scientific basis for the clinical application of such training to enhance patients' QOL. Methods Sample and SettingEighty patients with breast cancer receiving chemotherapy at Tangshan People's Hospital, a grade A tertiary hospital in Tangshan, Hebei, China,

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Section: Pre-and Postintervention Scores Of Ms and Av Groups For Rbmt...mentioning

confidence: 99%

Chemo Checker: Transforming Care and Increasing Patient Safety by Reducing Nurse Distractions

Adams

Waldo

Brodie

et al. 2022

CJON

View full text Add to dashboard Cite

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“…On one hand, external stimuli in sleep rarely affect perception 14 , suggesting response attenuation in cortical sensory regions. However, discriminative processing during sleep does persist for behaviorally-relevant or semantic incongruent stimuli 6,[15][16][17] as well as for contextual cues in targeted memory reactivation (TMR) 18,19 . Recent animal studies reporting comparable responses in the primary auditory cortex (A1) across sleep and wakefulness now challenge the long held assumption that natural sleep, like deep anesthesia, limits an effective relay to sensory cortex ('thalamic gating) 20,212,3,[22][23][24] .…”

Section: Mainmentioning

confidence: 99%

Impaired top-down auditory processing despite extensive single-neuron responses during human sleep

Hayat

Marmelshtein

Krom

et al. 2021

Preprint

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Sleep is defined as a reversible, homeostatically-regulated state of a reduced behavioral responsiveness, and a high arousal threshold in response to external sensory stimulation defines sleep across all species. However, it remains unclear whether sleep mainly gates motor output or affects responses along sensory pathways, and if sleep primarily modulates specific aspects of the sensory response such as feedforward vs. feedback signaling. Here, we simultaneously recorded polysomnography, iEEG, microwire LFPs, and neuronal spiking activity in epilepsy patients implanted with clinical depth electrodes, while presenting auditory stimuli (e.g. click-trains, words, music) during wakefulness and sleep. We found robust spiking and induced LFP high-gamma (80-200Hz) power responses during both NREM and REM sleep across the lateral temporal lobe whose magnitude was only moderately attenuated, most notably for late responses beyond early auditory cortex. Nonetheless, sleep responses maintained their tight locking with soundwave envelopes and their information content was minimally affected. By contrast, LFP alpha-beta (10-30Hz) power decrease was prevalent in wakefulness but significantly disrupted in sleep. Entrainment to 40Hz click-trains was comparable across REM sleep and wakefulness but reduced in NREM sleep. Together, our results establish extensive and robust auditory responses during sleep while LFP alpha-beta power decrease, likely reflecting top-down processes, is deficient. More broadly, they point to feedback signalling as key in conscious sensory processing.

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“…Meanwhile, Choi et al introduced vibration stimulation for a feedback of heart rate monitoring during sleep [42]. To the best of our knowledge, other sensory modalities such as olfactory stimulation [22,23,43] or visual stimulation [44] have never been introduced in closed-loop feedback systems for sleep. Therefore, it is believed that there is great potential to expand the sleep research boundary to various closed-loop sensory feedback areas.…”

Section: Stimulation Modalitymentioning

confidence: 99%

A Systematic Review of Closed-Loop Feedback Techniques in Sleep Studies—Related Issues and Future Directions

Choi

Kwon

Jun

2020

Sensors

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Advances in computer processing technology have enabled researchers to analyze real-time brain activity and build real-time closed-loop paradigms. In many fields, the effectiveness of these closed-loop protocols has proven to be better than that of the simple open-loop paradigms. Recently, sleep studies have attracted much attention as one possible application of closed-loop paradigms. To date, several studies that used closed-loop paradigms have been reported in the sleep-related literature and recommend a closed-loop feedback system to enhance specific brain activity during sleep, which leads to improvements in sleep’s effects, such as memory consolidation. However, to the best of our knowledge, no report has reviewed and discussed the detailed technical issues that arise in designing sleep closed-loop paradigms. In this paper, we reviewed the most recent reports on sleep closed-loop paradigms and offered an in-depth discussion of some of their technical issues. We found 148 journal articles strongly related with ‘sleep and stimulation’ and reviewed 20 articles on closed-loop feedback sleep studies. We focused on human sleep studies conducting any modality of feedback stimulation. Then we introduced the main component of the closed-loop system and summarized several open-source libraries, which are widely used in closed-loop systems, with step-by-step guidelines for closed-loop system implementation for sleep. Further, we proposed future directions for sleep research with closed-loop feedback systems, which provide some insight into closed-loop feedback systems.

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Local Targeted Memory Reactivation in Human Sleep

Abstract: Highlights d Presenting odors to one nostril in sleep achieves local TMR in one brain hemisphere d Local TMR selectively improves hemisphere-related memories for specific words d Local TMR differentially modulates slow-wave and spindle power across hemispheres

Cited by 41 publications

References 83 publications

Chemo Checker: Transforming Care and Increasing Patient Safety by Reducing Nurse Distractions

Chemo Checker: Transforming Care and Increasing Patient Safety by Reducing Nurse Distractions

Impaired top-down auditory processing despite extensive single-neuron responses during human sleep

A Systematic Review of Closed-Loop Feedback Techniques in Sleep Studies—Related Issues and Future Directions

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