Local Temperature Changes and Human Skeletal Muscle Metabolism.

Binzoni, Tiziano; Delpy, David T.

doi:10.2114/jpa.20.159

Cited by 6 publications

(5 citation statements)

References 62 publications

(93 reference statements)

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“…This mathematical result is consistent with the fact that n(T) seems to decrease at low T (Bottinelli and Reggiani 2000). A more exhaustive discussion on the T dependence of the bioenergetic equation may be found in Binzoni and Delpy (2001).…”

Section: Oxidative Metabolism and Temperature: Near Infrared Spectrossupporting

confidence: 85%

Human skeletal muscle energy metabolism: when a physiological model promotes the search for new technologies

Binzoni

2003

European Journal of Applied Physiology

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The idea that muscle function and, in fact, the function of all living tissues may be described by physical laws appeared in the second half of the 19th century. During this period, Helmoltz (Uber die Erhaltung der Kraft, 1847) showed that the principle of energy conservation may be applied to living systems. In the field of exercise physiology, this idea has been subsequently developed by Rodolfo Margaria's (1901-1983) School and the mathematical formalization of the theory has succeeded in the bioenergetic model. During the last 20 years methodical and critical study of the bioenergetic model has been carried out by Paolo Cerretelli, one of the most important heirs of Rodolfo Margaria's School. Original results and technological developments have been generated by his activity and many young scientists have been educated in this approach. The present paper wants to present the modern history of the bioenergetic model and is dedicated to Paolo Cerretelli on the occasion of his seventieth birthday.

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Section: Oxidative Metabolism and Temperature: Near Infrared Spectrossupporting

confidence: 85%

Human skeletal muscle energy metabolism: when a physiological model promotes the search for new technologies

Binzoni

2003

European Journal of Applied Physiology

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“…For human skeletal muscle, locally reducing temperature generally reduces the ability of muscle to generate active tension 26, 27 , but little is known about how local tissue cooling affects biochemical and molecular processes in human muscle tissue 28 . One published model predicts a decrease of 0.17 mM of ATP and 0.54 mM of phosphocreatine per 1 °C reduction in IM temperature 8 , however local cooling of the quadriceps muscle group with a cuff perfused with 0 °C water for 1 hour does not change the levels of ATP, creatine or phosphocreatine 29 .…”

Section: Discussionmentioning

confidence: 99%

Local cryotherapy minimally impacts the metabolome and transcriptome of human skeletal muscle

Sarver

Sugg

Disser

et al. 2017

Sci Rep

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Cryotherapy is commonly used in the treatment of skeletal muscle injuries. However, the data to support the use of cryotherapy is inconclusive, and the biochemical etiology of cryotherapy in human skeletal muscle remains largely unknown. We therefore sought to determine how a clinically-relevant dose of cryotherapy would impact the transcriptome and metabolome of skeletal muscle. Eight healthy male subjects (age 24.7 ± 4.5 years, BMI 22.2 ± 1.6) received a 15 minute bout of local cryotherapy, delivered via ice cup massage over the anterolateral thigh. This resulted in an 85% decrease in skin temperature and a predicted 27% reduction in intramuscular temperature. The contralateral side served as a non-treated control. Two hours after cryotherapy, muscle biopsies were obtained to analyze changes in the transcriptome, metabolome, and activation of p38 MAPK, ERK1/2, Akt, and p70S6K proteins. No changes were detected in the transcriptome between control and cooled muscles. Cryotherapy reduced levels of hexose sugars and hypoxanthine by 1.3%, but no statistically different changes were observed in 60 additional metabolites. Overall, no differences in phosphorylated p38 MAPK, ERK1/2, Akt, and p70S6K were observed. A clinically relevant dose of cryotherapy produced negligible acute biochemical and molecular changes in the skeletal muscle of human subjects.

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“…It was suggested that developing techniques of measuring local oxygen uptake was essential in order to study human muscle metabolism over a large range of Tm 60) . Recently, several studies directly measured the temperature dependence of muscle metabolism using near infrared spectroscopy (NIRS) [61][62][63] .…”

Section: Neuromuscular Functionmentioning

confidence: 99%

Exercise performance in acute and chronic cold exposure

Wakabayashi

Oksa

Tipton

2015

JPFSM

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This review focuses on the suppression of physical performance in a cold environment and the underlying physiological mechanisms. There are many situations where humans have to perform physical activities in a cold environment. Cold environments often limit exercise and working performance by impairing functions such as force production, velocity, power and manual dexterity. A muscle temperature of around 27°C is assumed to be a critical temperature below which maximal voluntary isometric force starts to decrease. The endurance time of submaximal isometric contractions peak at muscle temperatures of 27 to 28°C and decrease rapidly above and below these temperatures. Dynamic exercise performance, especially fast velocity movement, is generally more disturbed by cooling than isometric contractions. Additionally, the effect of cold adaptation on exercise performance, and the potential related mechanisms are summarized here based on a limited number of studies. Since the involuntary muscle contraction of shivering disturbs fine motor control, habituation of shivering, which is an example of cold adaptation, potentially improves exercise performance. Higher hand skin temperatures, induced by greater cold induced vasodilatation after local cold adaptation, could improve manual dexterity. Since there have been few studies testing the effect of cold adaptation on exercise performance in a cold environment, further studies seem warranted.

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Local Temperature Changes and Human Skeletal Muscle Metabolism.

Cited by 6 publications

References 62 publications

Human skeletal muscle energy metabolism: when a physiological model promotes the search for new technologies

Human skeletal muscle energy metabolism: when a physiological model promotes the search for new technologies

Local cryotherapy minimally impacts the metabolome and transcriptome of human skeletal muscle

Exercise performance in acute and chronic cold exposure

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