Local Thickness of Epicardial Adipose Tissue Surrounding the Left Anterior Descending Artery Is a Simple Predictor of Coronary Artery Disease　― New Prediction Model in Combination With Framingham Risk Score ―

Maimaituxun, Gulinu; Shimabukuro, Michio; Fukuda, Daiju; Yagi, Shusuke; Hirata, Yoshihiro; Igarashi, Takashi; Sugiyama, Takao; Matsuura, Tomomi; Ise, Takayuki; Kusunose, Kenya; Tobiume, Takeshi; Yamaguchi, Koji; Yamada, Hirotsugu; Soeki, Takeshi; Wakatsuki, Tetsuzo; Harada, Masafumi; Sata, Masataka

doi:10.1253/circj.cj-17-1289

Cited by 23 publications

(22 citation statements)

References 34 publications

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“…19 Previously, we reported on the relationship between CAD and EAT. 6,7,[20][21][22] In the present study the expression of VEGFs and CCL2 in focal adjacent EAT increased in the lipid-rich group, suggesting that the inflammation in focal adjacent EAT is associated with coronary plaque vulnerability. Conversely, ADIPOQ expression was slightly lower in lipid-rich coronary plaque lesions.…”

Section: Expression Of Inflammatory Moleculessupporting

confidence: 53%

Atherosclerotic Coronary Plaque Is Associated With Adventitial Vasa Vasorum and Local Inflammation in Adjacent Epicardial Adipose Tissue in Fresh Cadavers

Ito

Wakatsuki

Yamaguchi

et al. 2020

Circ J

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Background: The coronary adventitia has recently attracted attention as a source of inflammation because it harbors nutrient blood vessels, termed the vasa vasorum (VV). This study assessed the link between local inflammation in adjacent epicardial adipose tissue (EAT) and coronary arterial atherosclerosis in fresh cadavers. Methods and Results: Lesion characteristics in the left anterior descending coronary artery of 10 fresh cadaveric hearts were evaluated using integrated backscatter intravascular ultrasound (IB-IVUS), and the density of the VV and levels of inflammatory molecules from the adjacent EAT were measured for each of the assessed lesions. The lesions were divided into lipid-rich, lipid-moderate, and lipid-poor groups according to percentage lipid volume assessed by IB-IVUS. Higher expression of inflammatory molecules (i.e., vascular endothelial growth factor A [VEGFA] and VEGFB) was observed in adjacent EAT of lipid-rich (n=11) than in lipid-poor (n=11) lesions (7.99±3.37 vs. 0.45±0.85 arbitrary units [AU], respectively, for VEGFA; 0.27±0.15 vs. 0.11±0.07 AU, respectively, for VEGFB; P<0.05). The density of adventitial VV was greater in lipid-rich than lipid-poor lesions (1.50±0.58% vs. 0.88±0.23%; P<0.05). Conclusions: Lipid-rich coronary plaques are associated with adventitial VV and local inflammation in adjacent EAT in fresh cadavers. This study suggests that local inflammation of EAT is associated with coronary plaque progression via the VV.

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Section: Expression Of Inflammatory Moleculessupporting

confidence: 53%

Atherosclerotic Coronary Plaque Is Associated With Adventitial Vasa Vasorum and Local Inflammation in Adjacent Epicardial Adipose Tissue in Fresh Cadavers

Ito

Wakatsuki

Yamaguchi

et al. 2020

Circ J

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“…Second, these cytokines could develop coronary atherosclerosis and then damage the myocardium through myocardial ischemia. In a study with multi-detector computed tomography coronary angiography, EAT thickness surrounding the left anterior descending artery predicted the presence, extent and severity of coronary artery disease after adjustment for confounding factors [ 29 ]. Furthermore, in patients with acute coronary syndrome, perivascular fat stranding was related to the culprit lesion, a lower Agatston score, presence of regional wall motion abnormalities, and initial elevation of serum troponin levels [ 30 ].…”

Section: Discussionmentioning

confidence: 99%

Association between epicardial adipose tissue, high-sensitivity C-reactive protein and myocardial dysfunction in middle-aged men with suspected metabolic syndrome

Cho

Joo

Kim

et al. 2018

Cardiovasc Diabetol

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BackgroundAs body fat composition and metabolism differ between men and women, we evaluated sex-related differences in the association among epicardial adipose tissue (EAT), secretome profile, and myocardial function of subjects with suspected metabolic syndrome.MethodsWe evaluated 277 participants (men, n = 140; 56.1 ± 4.7 years) who underwent conventional echocardiography and two-dimensional speckle tracking from the Seoul Metabolic Syndrome cohort. EAT was measured from the right ventricular free wall perpendicular to the aortic annulus at end systole. Global longitudinal strain (GLS) was obtained from 18 apical segments. Apolipoprotein A1, apolipoprotein B, adiponectin, and high-sensitivity C-reactive protein (hs-CRP) levels were measured using immunoturbidimetry assay.ResultsMean age, body mass index, and hs-CRP level did not differ by sex. Waist circumference, fasting blood glucose level, and triglyceride/high-density lipoprotein cholesterol ratio were higher, and apolipoprotein AI and adiponectin levels were lower in men. No significant difference in mean EAT thickness was found (7.02 ± 1.81 vs. 7.13 ± 1.70 mm, p = 0.613). Men had a higher left ventricular (LV) mass index and lower GLS. EAT thickness was associated with hs-CRP level in men alone (ß = 0.206, p = 0.015). LV mass index (ß = 2.311, p = 0.037) and function represented by e′ (ß = − 0.279, p = 0.001) and GLS (ß = − 0.332, p < 0.001) were independently associated with EAT thickness in men alone.ConclusionsIn middle-aged subjects with suspected metabolic syndrome, EAT was associated with inflammation represented by hs-CRP level, LV mass, and subclinical myocardial dysfunction only in men, suggesting that the inflammatory activity of EAT induced myocardial remodeling and dysfunction in middle-aged subjects but was attenuated in women.Trial registration NCT02077530 (date of registration: November 1, 2013)

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“…EATV and local EAT thicknesses were measured as previously reported. [13][14][15] EAT thickness measurements were performed around the left anterior descending artery (EATLAD), right coronary artery (EATRCA), and left circumflex artery (EATLCX) as described; 15 similar measurements were also made around the LV wall (EATLV), right ventricular wall (EATRV), left atrial wall (EATLA), and right atrial wall (EATRA). Representative measurements from patients with and without LVDD are shown in Figure 1.…”

Section: Echocardiographic Parametersmentioning

confidence: 99%

“…For Models 6-8, the LVMI was added to Models 3-5, because this index was assumed to affect both LVDD parameters and EATV. 15 The optimal cutoff values for BMI, EATV index, EATLCX, and EATLV for predicting LVDD were identified using receiveroperating characteristic (ROC) curves. For all tests, statistical significance was set at P<0.05.…”

Section: Eatv Index and Eatlcx Cutoffs For Detecting Lvddmentioning

confidence: 99%

Association of Local Epicardial Adipose Tissue Depots and Left Ventricular Diastolic Performance in Patients With Preserved Left Ventricular Ejection Fraction

Maimaituxun

Yamada

Fukuda

et al. 2020

Circ J

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Background: Although full-volume quantification of epicardial adipose tissue (EAT) is a predictor of LV diastolic dysfunction (LVDD), how localized EAT depots are linked to LVDD remains unclear. We evaluated the effect of local EAT depots on LV diastolic function parameters in patients with preserved LV ejection fraction (LVEF). Methods and Results: From 423 consecutive patients who underwent cardiac CT angiography, we recruited 252 with sinus rhythm and normal LVEF. The EAT volume index (EATV/body surface area) and the localized EAT thickness around the right coronary artery (EATRCA), left anterior descending artery (EATLAD), left circumflex artery (EATLCX), right ventricle (EATRV), left ventricle (EATLV), right atrium (EATRA), and left atrium (EATLA) were measured using cardiac CT. In the LVDD group (n=71), the EATV index (75±30 vs. 64±28 mL/m 2 , P=0.010), EATLCX (10.7±3.8 vs. 9.4±3.4 mm, P=0.008), and EATLV (2.6±1.6 vs. 2.1±1.4 mm, P=0.024) were greater than in the non-LVDD group (n=181). In contrast, EATLCX and EATLV were markedly associated with decreased lateral e' and increased lateral E/e'. Multiple regression analysis indicated that EATLCX and EATLV were strongly associated with LV diastolic function parameters. Conclusions: Localized EAT depots are linked to altered mitral annular motion. Further study is warranted to clarify whether localized EAT depots are functionally linked to the clinical manifestations of LVDD.

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Local Thickness of Epicardial Adipose Tissue Surrounding the Left Anterior Descending Artery Is a Simple Predictor of Coronary Artery Disease　― New Prediction Model in Combination With Framingham Risk Score ―

Cited by 23 publications

References 34 publications

Atherosclerotic Coronary Plaque Is Associated With Adventitial Vasa Vasorum and Local Inflammation in Adjacent Epicardial Adipose Tissue in Fresh Cadavers

Atherosclerotic Coronary Plaque Is Associated With Adventitial Vasa Vasorum and Local Inflammation in Adjacent Epicardial Adipose Tissue in Fresh Cadavers

Association between epicardial adipose tissue, high-sensitivity C-reactive protein and myocardial dysfunction in middle-aged men with suspected metabolic syndrome

Association of Local Epicardial Adipose Tissue Depots and Left Ventricular Diastolic Performance in Patients With Preserved Left Ventricular Ejection Fraction

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Local Thickness of Epicardial Adipose Tissue Surrounding the Left Anterior Descending Artery Is a Simple Predictor of Coronary Artery Disease ― New Prediction Model in Combination With Framingham Risk Score ―

Cited by 23 publications

References 34 publications

Atherosclerotic Coronary Plaque Is Associated With Adventitial Vasa Vasorum and Local Inflammation in Adjacent Epicardial Adipose Tissue in Fresh Cadavers

Atherosclerotic Coronary Plaque Is Associated With Adventitial Vasa Vasorum and Local Inflammation in Adjacent Epicardial Adipose Tissue in Fresh Cadavers

Association between epicardial adipose tissue, high-sensitivity C-reactive protein and myocardial dysfunction in middle-aged men with suspected metabolic syndrome

Association of Local Epicardial Adipose Tissue Depots and Left Ventricular Diastolic Performance in Patients With Preserved Left Ventricular Ejection Fraction

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Local Thickness of Epicardial Adipose Tissue Surrounding the Left Anterior Descending Artery Is a Simple Predictor of Coronary Artery Disease　― New Prediction Model in Combination With Framingham Risk Score ―