Local Treatment of Prosthetic Vascular Graft Infection with Multivesicular Liposome-Encapsulated Amikacin

Huh, Joseph; Chen, John C.; Furman, Grace M.; Malki, Charles; King, Bryan O.; Kafie, Fernando E.; Wilson, Samuel E.

doi:10.1006/jsre.1997.5188

Cited by 24 publications

(12 citation statements)

References 15 publications

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“…There is considerable research interest in antibiotic-bonded grafts such as a rifampingelatin impregnation; however, the already low incidence of graft infection makes clinical proof of efficacy difficult to obtain [6]. Other substances bonded to Dacron grafts and shown to reduce the incidence of prosthetic graft infection in animal studies include polycationic peptides [7], liposome-encapsulated amikacin [8], and levofloxacin [9]. Gentamicin beads have been implanted in patients, either temporarily or permanently, for either treatment or prophylaxis of patients at high risk [10].…”

Section: Prevention Of Graft Infectionmentioning

confidence: 99%

New Alternatives in Management of the Infected Vascular Prosthesis

Wilson

2001

Surgical Infections

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Advances in the management of infected vascular prostheses over the last decade have led to improved mortality and decreased amputation rates with conventional excision and extraanatomical bypass. Newer methods including in situ graft replacement with antibiotic-impregnated prosthetics appear suitable for low-virulence S. epidermidis infection. Early results are promising for cryopreserved allografts and autogenous femoral vein in situ grafts; however, more clinical experience and longer follow-up will be needed to confirm their durability in a contaminated field.

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Section: Prevention Of Graft Infectionmentioning

confidence: 99%

New Alternatives in Management of the Infected Vascular Prosthesis

Wilson

2001

Surgical Infections

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“…We hypothesized that if a deep wound infection, i.e., an infection originating near the prosthetic material (III°), is recognized early enough, therapeutic modalities other than surgical removal of all prosthetic material can be considered. In the literature, systemic and local application of antibiotics are discussed 1,13 , 14 . Continuous catheter irrigation and drainage have been reported 15–17 .…”

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confidence: 99%

Treatment of periprosthetic soft tissue infection of the groin following vascular surgical procedures by means of a polyvinyl alcohol‐vacuum sponge system

Pinocy¹,

Albes

Wicke³

et al. 2003

Wound Repair Regeneration

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Deep groin infections after prosthetic vascular surgical procedures represent a serious complication of surgical practice. Septicemia and/or erosive hemorrhage can both be consequences. In this situation, removal of the graft appears to be the only option. However, if the infection is detected early (type Szilagyi III), local treatment to eradicate the infection could serve as an alternative. Twenty-four patients with confirmed infection of the soft tissue adjacent to the prosthetic material in the groin were treated locally by implantation of a vacuum sponge system. Duration of this treatment was 2 weeks. All patients showed excellent tissue granulation of the wound area and the microbial stains were negative at the end of therapy. In 21 patients the wound could be primarily closed after explantation of the sponge. Three patients underwent open treatment because of a skin defect. After 12 months, the wounds had healed well in all patients. Histologic evaluation revealed a physiological healing process. Deep soft tissue infections of the groin adjacent to prosthetic vascular material (type Szilagyi III) can be treated effectively and safely with the vacuum sponge system. The treatment is inexpensive, easy to perform, and the initial vascular reconstruction can be preserved.

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“…Их применение дает обнадеживающие результаты. Экспериментально апробируются и другие виды антибактериальных покрытий протезов: амикацин, ванкомицин, тейкопланин и 40% фузидиевая кислота [28,29].…”

Section: рис 3 кт-данные больных с ипаunclassified

Surgical treatment of aortic graft infections

Charchyan¹,

Shestakov²,

Galeev³

et al. 2018

Kardiol. serdechno-sosud. khir.

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Частота глубоких инфекционных осложнений после кардиохирургических операций сохраняется на достаточно высоком уровне-0,5-4%, смертность при этом осложнении-до 50% [1]. Частота инфекций протеза аорты (ИПА) при вмешательстве на грудной аорте достигает 1-3% [2, 3], летальность-25-75%, а лечение в большинстве случаев сложное и длительное [4]. Фатальные осложнения при

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Local Treatment of Prosthetic Vascular Graft Infection with Multivesicular Liposome-Encapsulated Amikacin

Cited by 24 publications

References 15 publications

New Alternatives in Management of the Infected Vascular Prosthesis

New Alternatives in Management of the Infected Vascular Prosthesis

Treatment of periprosthetic soft tissue infection of the groin following vascular surgical procedures by means of a polyvinyl alcohol‐vacuum sponge system

Surgical treatment of aortic graft infections

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