Local tumor invasiveness is more predictive of survival than International Prognostic Index in stage IE/IIE extranodal NK/T-cell lymphoma, nasal type

Kim, Tae Min; Park, Yeon Hee; Lee, Sang Yoon; Kim, Jihoon; Kim, Dong-Wan; Im, Seock‐Ah; Kim, Tae-You; Kim, Chul Woo; Heo, Dae Seog; Bang, Yung‐Jue; Chang, Kee-Hyun; Kim, Noe Kyeong

doi:10.1182/blood-2005-05-2056

Cited by 157 publications

(146 citation statements)

References 33 publications

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“…CHOP is regarded as the standard chemotherapy regimen for aggressive NHL, however, its effect in patients with extranodal NK/T-cell lymphoma, nasal type, is usually inferior. In the present study, a CR rate of 33% was achieved, which is consistent with previous literatures [8,18]; 35% of patients had PD during chemotherapy, suggesting primary drug-resistance may exist in some patients. P-gp, encoded by mdr-1 gene, has been extensively studied in various types of malignancies.…”

Section: Discussionsupporting

confidence: 93%

Immunohistochemical expression and clinical significance of P‐glycoprotein in previously untreated extranodal NK/T‐cell lymphoma, nasal type

Wang

et al. 2008

American J Hematol

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Overexpression of P-glycoprotein (P-gp) has been identified by a variety of methods in NK cells and NK malignancies. The aim of this study was to determine the clinical significance of P-gp in previously untreated extranodal NK/T-cell lymphoma, nasal type. Tumor specimens from 30 patients initially treated with CHOP or CHOP-based chemotherapy were examined by immunohistochemistry using JSB-1, a monoclonal antibody recognizing the intracellular epitope of P-gp molecule. Twenty cases (67%) were positive for P-gp expression. The complete response rate achieved in P-gp positive patients was significantly lower than in P-gp negative ones (20% vs. 60%, P = 0.045). With a median follow-up of 25 months, the 2-year progression-free survival (PFS) and overall survival (OS) rates for all patients were 66 and 69%, respectively. Compared with both PFS and OS rates of P-gp positive patients, those of P-gp negative patients showed a trend of benefit that did not reach statistical significance for borderline P values (PFS: 90% vs. 54%, P = 0.1057; OS: 90% vs. 61%, P = 0.2028). Our results suggest that P-gp expression is related with poor treatment outcomes of extranodal NK/T-cell lymphoma, nasal type. Am. J. Hematol. 83:795-799, 2008. V

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Section: Discussionsupporting

confidence: 93%

Immunohistochemical expression and clinical significance of P‐glycoprotein in previously untreated extranodal NK/T‐cell lymphoma, nasal type

Wang

et al. 2008

American J Hematol

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“…For UNKTLs, LTI was defined as bony invasion or perforation or invasion of the skin. 1,28 For EUNKTLs, the definition of LTI was different based on the originally involved sites. For EUNKTL primarily involving gastrointestinal tract, T4 tumor in TNM system was considered as LTI.…”

Section: Data Collectionmentioning

confidence: 99%

Prognostic impact of absolute lymphocyte count/absolute monocyte count ratio and prognostic score in patients with nasal-type, extranodal natural killer/T-cell lymphoma

Zhang

Song

et al. 2017

Tumour Biol.

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Nasal-type, extranodal natural killer/T-cell lymphoma is a heterogeneous disorder with poor prognosis, requiring risk stratification in this population. The combined value of baseline absolute lymphocyte count and absolute monocyte count provided prognostic information in some malignancies. However, the evidence requires validation in extranodal natural killer/T-cell lymphoma. Aiming to investigate the prognostic significance of absolute lymphocyte count/absolute monocyte count ratio and absolute lymphocyte count/absolute monocyte count prognostic score for extranodal natural killer/Tcell lymphoma, a retrospective research was carried out. A total of 264 patients with newly diagnosed extranodal natural killer/T-cell lymphoma were analyzed in this study. The patients' absolute lymphocyte count and absolute monocyte count tested at initial diagnosis were collected. Receiver operating curve analysis showed that the optimal cut-off values for absolute lymphocyte count and absolute monocyte count were 1.0 × 10 9 and 0.5 × 10 9 L −1 , respectively, and for absolute lymphocyte count/absolute monocyte count ratio was 2.85. After a median follow-up of 27 months (range 1-87 months), the 3-year overall survival and progression-free survival was 75.4% and 67.6%, respectively. Patients with absolute lymphocyte count/absolute monocyte count ratio ≥ 2.85 had better 3-year overall survival and progressionfree survival than those with absolute lymphocyte count/absolute monocyte count ratio <2.85 (p < 0.001). According to absolute lymphocyte count/absolute monocyte count prognostic score, significant difference has been noticed in 3-year overall survival and progression-free survival (p < 0.001) and high absolute lymphocyte count/absolute monocyte count prognostic score was associated with poorer survival. The International Prognostic Index and Korean Prognostic Index were used for prognosis and showed no significant difference. When adding absolute lymphocyte count/absolute monocyte count ratio and absolute lymphocyte count/absolute monocyte count prognostic score to the International Prognostic Index and Korean Prognostic Index model, additional prognostic information was found. These results suggest that absolute lymphocyte count/absolute monocyte count ratio and absolute lymphocyte count/absolute monocyte count prognostic score might be useful prognostic factors in extranodal natural killer/T-cell lymphoma.

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“…Прогноз при ЭНКТЛ варьирует, и, по данным разных авторов, 5-летняя общая выживаемость (ОВ) колеб-лется от 30 до 50 % [23,24]. Эффективность стандарт-ной химиотерапии отмечена лишь в редких случаях ЭНКТЛ, большая часть больных погибает от прогрес-сирования заболевания.…”

Section: Introductionunclassified

“…Применение классификации Ann Arbor, успешно используемой при лимфоме Ход-жкина и других агрессивных нодальных лимфомах, оказалось неоправданным для стадирования ЭНКТЛ в связи с сомнительным прогностическим значением и преимущественной экстранодальной локализацией первичных очагов поражения ЭНКТЛ [25]. Кроме то-го, многие исследователи отмечали низкое прогности-ческое значение IPI [23,24], поэтому большое коли-чество исследовательских работ было посвящено поиску прогностических факторов при ЭНКТЛ. Так, например, в корейском многоцентровом ретроспек-тивном исследовании был разработан прогностиче-ский индекс (NK-PI, или «корейский индекс»), вклю-чающий 4 независимых фактора прогноза: наличие В-симптомов, III-IV стадия, повышение активности ЛДГ, вовлечение регионарных ЛУ [25].…”

Section: Introductionunclassified

“…Проведенное международное исследование показало, что экстраназальный тип, чаще встречающийся в Азии, характеризуется более короткой продолжительностью жизни в сравнении с назальным типом [6]. В других исследовательских работах было отмечено неблаго-приятное прогностическое значение инвазивного ро-ста опухоли с поражением смежных структур, кожи, костного мозга и костей [23,25]. Выявление ДНК ВЭБ и наличие ВЭБ-позитивных клеток в периферической крови и костном мозге также признано фактором, кор-релирующим с прогнозом заболевания и ОВ [29,30].…”

Section: Introductionunclassified

See 1 more Smart Citation

Extranodal NK/T-cell lymphoma: a review of literature and case report

Чернова¹,

Nareiko²,

Синицына³

et al. 2016

Onkogematologiâ

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Local tumor invasiveness is more predictive of survival than International Prognostic Index in stage IE/IIE extranodal NK/T-cell lymphoma, nasal type

Cited by 157 publications

References 33 publications

Immunohistochemical expression and clinical significance of P‐glycoprotein in previously untreated extranodal NK/T‐cell lymphoma, nasal type

Immunohistochemical expression and clinical significance of P‐glycoprotein in previously untreated extranodal NK/T‐cell lymphoma, nasal type

Prognostic impact of absolute lymphocyte count/absolute monocyte count ratio and prognostic score in patients with nasal-type, extranodal natural killer/T-cell lymphoma

Extranodal NK/T-cell lymphoma: a review of literature and case report

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