Local use of sulfamido compounds in the treatment of infected wounds

Sulfathiazole (2-[paraaminobenzenesulfonamido]-thiazole), the newest of the sulfanilamide group of drugs, is ready to take its place in the armamentarium of chemotherapy. Sulfathiazole therapy has progressed so rapidly since the release of the drug that the literature associated with it is poorly organized. Our interest in the drug was stimulated by what impressed us as an almost unbelievable therapeutic result in what we had feared was an incurable condition. The report of this case follows. We feel that a preliminary review of the literature concerning sulfathiazole is worth while at this time.Sulfathiazole is the thiazole analogue of sulfapyridine (2-[paraaminobenzenesulfonamido]-pyridine) and was first reported by Forsbinder and Walter 1 and by Lott and Bergeim.2 These authors described the methods of preparation and their experiments with these drugs against streptococcic and pneumococcic infections in mice. The original work on the physical and chemical characteristics of sulfathiazole and its salt was done at that time, and the tests for the estimation of the drug in the blood were described.Van Dyke 3 and his co-workers showed the rapid metabolism of this drug in the body. Sulfathiazole was proved to be more rapidly absorbed than the other sulfanilamide derivatives, the blood concentration reaching its highest level in one to three hours after ingestion. Further, it dis-

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Observations on the Topical Use of Sulfonamide Derivatives

Bick¹

1942

JAMA

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Local use of sulfamido compounds in the treatment of infected wounds

Cited by 3 publications

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Topical Treatment With Sulfathiazole

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Observations on the Topical Use of Sulfonamide Derivatives

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