2022
DOI: 10.1002/jor.25499
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Local zinc treatment enhances fracture callus properties in diabetic rats

Abstract: The effects of locally applied zinc chloride (ZnCl2) on early and late‐stage parameters of fracture healing were evaluated in a diabetic rat model. Type 1 Diabetes has been shown to negatively impact mechanical parameters of bone as well as biologic markers associated with bone healing. Zinc treatments have been shown to reverse those outcomes in tests of nondiabetic and diabetic animals. This study is the first to assess the efficacy of a noncarrier mediated ZnCl2 on bony healing in diabetic animals. This is … Show more

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Cited by 2 publications
(1 citation statement)
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“…Trace metals, such as copper (Cu) and zinc (Zn), are essential for skeleton health and regeneration [4]. Bone and cartilage are influenced by Zn 2+ and Cu 2+ ions that regulate the tissues' formation, metabolism, and homeostasis under physiological conditions [5][6][7]. Changes to the normal trace metal levels can alter bone turnover, increasing the risk of fractures.…”
Section: Introductionmentioning
confidence: 99%
“…Trace metals, such as copper (Cu) and zinc (Zn), are essential for skeleton health and regeneration [4]. Bone and cartilage are influenced by Zn 2+ and Cu 2+ ions that regulate the tissues' formation, metabolism, and homeostasis under physiological conditions [5][6][7]. Changes to the normal trace metal levels can alter bone turnover, increasing the risk of fractures.…”
Section: Introductionmentioning
confidence: 99%