Localisation of malignant germ-cell tumours by external scanning after injection of radiolabelled anti-alpha-fetoprotein.

Halsall, A.K.; Fairweather, D.S.; Bradwell, Arthur R.; Blackburn, Jessica; Dykes, P. W.; Howell, Anthony; Reeder, A.; Hine, K R

doi:10.1136/bmj.283.6297.942

Cited by 48 publications

(5 citation statements)

References 7 publications

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“…A similar situation has been observed with testicular teratomas producing alpha fetoprotein. This is considered to be an intracellular protein but antibody scanning again is successful (Halsall et al, 1981). One might suppose that tumours would be best located by antibodies directed against cell surface components rather than intracellular proteins, but many surface antigens are removed from the cell surface when combined with antibody (Editorial, 1982) and may not be ideal targets.…”

Section: Discussionmentioning

confidence: 99%

“…For the antibody scans all patients took oral KI and patients 7-12 also took KC104, in the doses described above. The technique of the antibody scanning was as previously described (Halsall et al, 1981) with two scans between 20 and 60 h post injection. Patients received between 18.2 and 37 MBq (0.5 to 1 mc1) of I3lI-anti-Tg which represented approximately 100 pg of IgG.…”

Section: Scanning Proceduresmentioning

confidence: 99%

“…These are usually proteins, produced in excess by the malignant cells, and detected in the serum of patients. In addition, radiolabelled antibodies directed against these proteins, when injected into patients, may frequently allow the site of the tumour to be accurately located (Dykes et al, 1980;Halsall et al, 1981). As more specific tumour markers are discovered the technique is likely to have wide application.In the case of thyroid carcinomas, thyroglobulin (Tg) is found in high concentrations in the malignant thyroid tissue and is a useful marker for tumour recurrence (Black et al, 1981).…”

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confidence: 99%

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Detection of Thyroid Tumours Using Radio‐labelled Anti‐thyroglobulin

Fairweather

Bradwell

Watson-James

et al. 1983

Clinical Endocrinology

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IgG antibody to human thyroglobulin was labelled with 131Iodine (131I) and used to locate deposits of thyroid follicular and papillary tumours with a gamma camera. Of twelve patients studied a total of 40 tumour 'areas' were detected by a variety of clinical and radiological techniques. Sixteen of these were detected using conventional 131I uptake scans whereas 34 were positive on the antibody scans. The difficulty of assessing diffuse pulmonary lesions (3 areas) and the possibility that free 131I from labelled antibody may have contributed to the antibody scan results in six areas left 31 definite areas for scan comparison. Twenty seven (87%) areas were positive on the antibody scan, nine (29%) were positive on conventional 131I scans whilst 24 (77%) areas were detected by a combination of clinical and other radiological criteria. Five areas were positive on the antibody scan alone but there was evidence, albeit indefinite, that these areas contained tumour. Four of the 31 areas were not detected by the antibody scans. The results indicate that anti-thyroglobulin scanning is more sensitive than conventional 131I-iodide scans and may contribute to the staging and management of thyroid cancer.

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Section: Discussionmentioning

confidence: 99%

Section: Scanning Proceduresmentioning

confidence: 99%

mentioning

confidence: 99%

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Detection of Thyroid Tumours Using Radio‐labelled Anti‐thyroglobulin

Fairweather

Bradwell

Watson-James

et al. 1983

Clinical Endocrinology

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“…These results were soon confirmed by other groups. [7][8][9][10][11][12] This method often suffers from a number of disadvantages such as different distribution of I-131 and Tc-99m in the circulation and in the urinary tract, a halo effect due to different energies of I-131 and Tc-99m, the thyroid and mucosa uptake of iodide, and the gut excretion of iodide.…”

Section: Introductionmentioning

confidence: 99%

Tumor scintigraphy by the method for subtracting the initial image with technetium-99m labeled antibody

et al. 1999

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The method for subtracting the initial image from the localization image was evaluated for radioimmunoscintigraphy of tumors with technetium-99m (Tc-99m) labeled antibodies. Monoclonal antibodies were parental mouse and mouse-human chimeric antibodies to carcinoembryonic antigen (CEA), designated F11-39 and ChF11-39, respectively, both of which have been found to discriminate CEA in tumor tissues from the CEA-related antigens. After reduction of the intrinsic disulfide bonds, these antibodies were labeled with Tc-99m. In vivo studies were performed on athymic nude mice bearing the human CEA-producing gastric carcinoma xenografts. Though biodistribution results showed selective and progressive accumulation of Tc-99m labeled antibodies at the tumor site, high radioactivity in blood was inappropriate for scintigraphic visualization of the tumors within a few hours. We examined the subtraction of the initial Tc-99m image from the Tc-99m localization image after a few hours. Subtracted images of the same count reflected the in vivo behavior of the Tc-99m radioactivity. The subtracted scintigrams revealed excellent tumor images with no significant extrarenal background. Visualization of the tumor site was dependent on antigen-specific binding and nonspecific exudation. These results demonstrate that a method of subtraction of the initial image may serve as a potentially useful diagnostic method for an abnormal site for agents with a low pharmacokinetic value.

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“…Again, the most favorable results were obtained for the differential diagnoses of scar and tumor tissue. Halsall et al [34] published a paper on the localization of malignant germ cell tumors by RID using anti-alpha-fetoprotein anti bodies. Eight years later, in 1989, similar results were obtained by Hitchins et al [35].…”

Section: Testicular Tumorsmentioning

confidence: 99%

Clinical Relevance of Radio-immunoimaging in Malignant Diseases

Biersack¹,

Hotze²,

Schultes³

et al. 1993

Oncol Res Treat

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First results of tumor imaging using radiolabelled antibodies date back to 1953. During the last 40 years an improvement of this diagnostic procedure was achieved by the use of monoclonal antibodies and new labelling techniques for short-lived isotopes. Up to now, three groups of patients take advantage of immunoimaging, namely patients with colorectal cancer, ovarian cancer, and malignant melanoma. In patients with recidivation of colorectal carcinoma the accuracy of radioimmunodetection (RID) is approximately 90%. The same holds true for patients with ovarian cancer; in these cases RID may decrease the frequency of second-look operations. RID has proved to be most useful in malignant melanomas, as its accuracy for lymph node and transit metastases is between 85 and 90%. However, in other malignancies – especially breast and lung cancer – RID did not yield similarly good results. An improvement of RID may be achieved by the use of bifunctional or recombinant antibodies.

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Localisation of malignant germ-cell tumours by external scanning after injection of radiolabelled anti-alpha-fetoprotein.

Cited by 48 publications

References 7 publications

Detection of Thyroid Tumours Using Radio‐labelled Anti‐thyroglobulin

Detection of Thyroid Tumours Using Radio‐labelled Anti‐thyroglobulin

Tumor scintigraphy by the method for subtracting the initial image with technetium-99m labeled antibody

Clinical Relevance of Radio-immunoimaging in Malignant Diseases

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