Localised extranodal non-Hodgkin's lymphoma of the tonsil: report of a rare case

Vasilakaki, Thivi; Myoteri, Despoina; Tsavari, Aikaterini; Skafida, E; Arkoumani, E.; Koulia, Kalliroi; Grammatoglou, Xanthippi; Manoloudaki, Kassiani

doi:10.13172/2052-0077-2-11-812

Cited by 3 publications

(5 citation statements)

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“…Next common location is orbital ENL (21%) and our observation is in concordance with Mishra P et al [2] Peak incidence in tonsils is seen in 6-7 decade with male preponderance. [7,12] In our study, tonsillar ENL is more in 4 th and 5 th decade with male: female ratio being 1.8:1. High index of suspicion needed as tonsillar ENL presents as progressive sore throat, partially relieved on treatment.…”

Section: Discussionsupporting

confidence: 49%

“…Most of tonsillar lymphoma are B cell phenotype with 67-96 % exhibiting DLBCL histology and DLBCL is often aggressive. [7,12] High grade transformation of pre-existent low-grade mucosa associated lymphoid tissue lymphoma (MALToma) or follicular lymphoma into DLBCL is known to occur. [1] In the present study, all tonsillar lymphoma were of B cell subtype with diffuse large cell lymphoma in 80 % cases (Fig 1).…”

Section: Discussionmentioning

confidence: 99%

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Histomorphological and Immunohistochemical Study of Extra Nodal Lymphoma

Vani¹,

Sandhyalakshmi²,

Sajjan³

et al. 2021

Ann of Pathol and Lab Med

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Background: NHL are heterogeneous group of hematolymphoid malignancy occurring in nodal and extra nodal sites. Extra nodal lymphoma (ENL) is distinct from nodal lymphomas due to varied anatomical location, morphological diversity. Methods: A retrospective observational study was conducted in the department of pathology from January 2011 till December 2019. Clinical details and other investigations were recorded. Gross morphological features were noted. Slides are reviewed microscopically and blocks were subjected to IHC for further typing cases were selected as per Dawson et al criteria. Result: During study period, ENL constituted 25 cases (29.4%) of the 85 cases of all NHL. Age range is 05 to 63 years with a mean age of 42.5 years. Male to female ratio is 2.2 :1.Head and neck is the most common site of ENHL constituting 19 cases(76%), next commonest location is in the GIT with 3 cases (12%). We had one each case of ENHL in testis, breast and spine (4% each). On IHC, 92% cases (23 cases) exhibited B cell phenotype and the remaining 08 % (02 cases) were of T cell phenotype. Conclusion: Lymphomas in the extra nodal sites are rare but has the propensity to occur in any anatomic site. Hence a differential of lymphoma to be considered in extra nodal site. Histology with IHC enables to differentiate from poorly differentiated carcinoma as the treatment modalities and prognosis varies.

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Section: Discussionsupporting

confidence: 49%

Section: Discussionmentioning

confidence: 99%

Histomorphological and Immunohistochemical Study of Extra Nodal Lymphoma

Vani¹,

Sandhyalakshmi²,

Sajjan³

et al. 2021

Ann of Pathol and Lab Med

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“…

he tonsil is a rare site of lymphoma. On this accordance, single cases have been reported from China, [1] Greece, [2] India, [3,4] Japan, [5] and Turkey. [6] Therefore, this paper presents five cases found in Nigeria among the Ibo indigenous group.

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mentioning

confidence: 88%

Lymphoma of the Tonsil in a Developing Community

I.B.Onuigbo

2018

Clin Res Hematol

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“…Squamous cell carcinoma (SCC) is the most common malignancy followed by Non-Hodgkin's lymphomas (NHL) in the tonsil. NHL of the oral cavity and oropharynx usually account for 13% of all primary extra nodal NHL with approximately 70% occurring in the tonsils [26]. The palatine tonsil is the most frequently involved site followed by palate, gingiva and tongue.…”

Section: International Journal Of Medical Research and Reviewmentioning

confidence: 99%

“…The peak incidence is in sixth and seventh decades of life with slight male predominance. Clinical presentation is not specific and is due to of asymmetrical tonsillar enlargement [26]. Babu et al [24] reported a total of 5 cases of tonsillar malignancy-two undifferentiated carcinomas, two NHLs, and one SCC.…”

Section: International Journal Of Medical Research and Reviewmentioning

confidence: 99%

Histopathological spectrum of lesions of tonsil- A 2 year experience from tertiary care hospital of Maharashtra, India

2016

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Background: Palatine tonsils are paired masses of lymphoid tissue which act as immunologic barrier against the entry of pathogenic agents into the respiratory and digestive tracts. Despite their protective function, tonsils are prone to infection. Tonsillitis is a common disease especially among the children. Chronic tonsillitis is a disease with repeated attacks of acute tonsillitis or a sub clinic form of a resistant or poorly treated infection. Aim: To study histopathology of various lesions of tonsil. Material and Methods: We studied histopathology of 211 cases representing surgical samples from 115 patients [Tonsillectomy-104 patients (Unilateral-08, Bilateral-96) and tonsillar biopsy in 11 patients]. Representative bits were taken from formalin fixed tonsillectomy specimens whereas biopsies were submitted entirely. Routine hematoxylin and eosin staining was done. Results: Amongst 211 cases, histopathological examination in 190 cases showed tonsillitis. The other lesions were cartilaginous choristoma in six patients, epidermal inclusion cyst in three cases and reactive lymphoid hyperplasia in one case. One case of inflammatory my fibroblastic tumors was observed. The malignancies were observed in ten cases-squamous cell carcinoma in nine cases and Non-Hodgkin lymphoma in one case.

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Localised extranodal non-Hodgkin's lymphoma of the tonsil: report of a rare case

Cited by 3 publications

References 6 publications

Histomorphological and Immunohistochemical Study of Extra Nodal Lymphoma

Histomorphological and Immunohistochemical Study of Extra Nodal Lymphoma

Lymphoma of the Tonsil in a Developing Community

Histopathological spectrum of lesions of tonsil- A 2 year experience from tertiary care hospital of Maharashtra, India

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