“…Significant behavioral changes, as observed in elevated plus-maze and open field study, clearly indicate the development of significant neurotoxicity upon administration of IBO as observed by Afees et al (2022) . The elevated plus-maze open field is a widely used behavioral experiment to assess the anxiolytic effects of pharmacologically active compounds ( Walf and Frye, 2007 , Sestakova et al, 2013 ).…”