Localization and characterization of members of a family of repetitive sequences in the goat βglobin locus

Spence, Sally E.; Young, Regina M.; Garner, Karen J.; Lingrel, Jerry B.

doi:10.1093/nar/13.6.2171

Cited by 31 publications

(8 citation statements)

References 67 publications

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“…1, the bovine genome contains three different kinds of dispersed repeat, namely, Bov-A2, Bov-tA, and Bov-B (using the nomenclature of Lenstra et al 1993). Bov-A represents the 115-bp A unit (Weiner et al 1986), which has also been designated BCS (Spence et al 1985) and BMF (Zelnick et al 1987). Bov-A2 is a homodimer of Bov-A (Fig.…”

Section: Resultsmentioning

confidence: 99%

The 3′ ends of tRNA-derived SINEs originated from the 3’ ends of LINEs: A new example from the bovine genome

Okada

Hamada

1997

J Mol Evol

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Our group demonstrated recently that the 3' ends of several families of tRNA-derived SINEs (short interspersed repetitive elements) originated from the 3' ends of LINEs (long interspersed repetitive elements) [Ohshima et al. (1996) Mol. Cell. Biol. 16:3756-3764]. Two fully characterized examples of such organization were provided by the tortoise Pol III/SINE and the salmonid HpaI family of SINEs, and two probable examples were provided by the tobacco TS family of SINEs and the salmon SmaI family of SINEs. This organization of SINEs can explain their potential to retropose in the genome since it appears reasonable that the sites for recognition of LINEs by reverse transcriptase should be located within the 3'-end sequences of LINEs. We now add another example to this category of SINEs. In the bovine genome, there are Bov-tA SINEs, which belong to the superfamily of tRNA-derived families of SINEs, and Bov-B LINEs, which were recently demonstrated to belong to a LINE family. Moreover, Bov-tA and Bov-B share the same 3'-end tail. We propose a possible scenario whereby the composite structure of the bovine Bov-tA family of SINEs might have been generated from the Bov-B family of LINEs during evolution.

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Section: Resultsmentioning

confidence: 99%

The 3′ ends of tRNA-derived SINEs originated from the 3’ ends of LINEs: A new example from the bovine genome

Okada

Hamada

1997

J Mol Evol

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“…repeats and the typical SINEs indicate that the f6rmer should be placed in a separate class of repetitive elements. Other investigators have reported non-Atu types of short interspersed repeats (21)(22)(23). Some of these are apparently retrotransposons and are inserted (22).…”

Section: Mouse Myoglobinmentioning

confidence: 95%

“…Other investigators have reported non-Atu types of short interspersed repeats (21)(22)(23). Some of these are apparently retrotransposons and are inserted (22). Another group of interspersed repeats is composed of tandem repetitions of short oligonucleotides, which are highly conserved (3,24,25).…”

Section: Mouse Myoglobinmentioning

confidence: 99%

Identification of a conserved sequence in the non-coding regions of many human genes

Donehower¹,

Slagle²,

Wilde

et al. 1989

Nucl Acids Res

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We have analyzed a sequence of approximately 70 base pairs (bp) that shows a high degree of similarity to sequences present in the non-coding regions of a number of human and other mammalian genes. The sequence was discovered in a fragment of human genomic DNA adjacent to an integrated hepatitis B virus genome in cells derived from human hepatocellular carcinoma tissue. When one of the viral flanking sequences was compared to nucleotide sequences in GenBank, more than thirty human genes were identified that contained a similar sequence in their non-coding regions. The sequence element was usually found once or twice in a gene, either in an intron or in the 5' or 3' flanking regions. It did not share any similarities with known short interspersed nucleotide elements (SINEs) or presently known gene regulatory elements. This element was highly conserved at the same position within the corresponding human and mouse genes for myoglobin and N-myc, indicating evolutionary conservation and possible functional importance. Preliminary DNase I footprinting data suggested that the element or its adjacent sequences may bind nuclear factors to generate specific DNase I hypersensitive sites. The size, structure, and evolutionary conservation of this sequence indicates that it is distinct from other types of short interspersed repetitive elements. It is possible that the element may have a cis-acting functional role in the genome.

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“…Contributing to this is the presence of a Nlu repeat at positions 2228-2307. This copy of the repeat shows 73% similarity to a sequence from the goat P-globin locus, in which the NZu repeat was first identified (Spence et al, 1985). This repeat is not present at this position in bovine BLG; however, a sequence with 84% sequence similarity is found at positions 6474-6553 in the 3' flanking region of ovine BLG (Harris et al, 1988).…”

Section: Comparison Of Bovine Blg and Y/-blg Y-blg Is Locatedmentioning

confidence: 71%

Characterisation of a Second, Apparently Inactive, Copy of the Bovine β‐lactoglobulin Gene

Passey

Mackinlay

1995

European Journal of Biochemistry

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A bovine cosmid clone was isolated which contains the previously characterised 8-lactoglobulin gene and, i n addition, a related sequence which appears to be a P-lactoglobulin pseudogene. The total length of the pseudogene, as determined by DNA sequencing, is 4.8 kb, similar to that of P-lactoglobulin. Both genes are in the same orientation and are separated by approximately 14 kb intergenic sequence. Although most of introns I-V are extremely divergent, the exon sequences are clearly related, exons I-V exhibiting nucleotide sequence siinilarities in the range 60-87%. Exons VI and VII, together with the final intron, comprise a region of sequence extending over 730 bp, which displays 92.5 % identity to the corresponding (I-lactoglobulin sequence. It is suggested that this is the result of a recent gene conversion event involving conversion of the pseudogene by the authentic P-lactoglobulin gene. Identification of the new lactoglobulin sequence as a pseudogene is based on the occurrence of a stop codon in exon V. Comparison of the inferred translation product encoded by the pseudogene before its mutational inactivation, with the sequences of equine and feline P-lactoglobulins I and 11, indicates that the bovine pseudogene is more closely related to these type-I1 lactoglobulin sequences than to the type-I sequences.

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Localization and characterization of members of a family of repetitive sequences in the goat βglobin locus

Cited by 31 publications

References 67 publications

The 3′ ends of tRNA-derived SINEs originated from the 3’ ends of LINEs: A new example from the bovine genome

The 3′ ends of tRNA-derived SINEs originated from the 3’ ends of LINEs: A new example from the bovine genome

Identification of a conserved sequence in the non-coding regions of many human genes

Characterisation of a Second, Apparently Inactive, Copy of the Bovine β‐lactoglobulin Gene

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