Abstract:Immunocytochemical and cryoultramicrotomy techniques were applied to label endogenous as well as intravenously injected calcitonin (CT) in rat kidney. Endogenous CT was located to the membranes of the brush border, endocytotic invaginations and vacuoles and dense apical tubules suggesting degradation at the brush border and/or within endocytotic vacuoles after glomerular filtration of endogeneous CT There was no labeling at the basolateral membranes indicating that possible basolateral binding sites are of min… Show more
“…Due to this property it has been widely used in optical or electron microscopy to label the cell membrane and study membrane recycling dynamics. It is thought to bind to proteoglycans present in the cell coat 29–31. Therefore such glycosylated proteins could be a target for 2 and could mediate its uptake depending on the ratio between metal complex and proteoglycan concentrations.…”
Section: Cytotoxicity and Lipophilicity Of 1–5mentioning
Shine a light: A ruthenium tris(bipyridyl) complex that was originally designed as a photosensitizer for solar cells has been found to adhere to plasma membranes.
“…Due to this property it has been widely used in optical or electron microscopy to label the cell membrane and study membrane recycling dynamics. It is thought to bind to proteoglycans present in the cell coat 29–31. Therefore such glycosylated proteins could be a target for 2 and could mediate its uptake depending on the ratio between metal complex and proteoglycan concentrations.…”
Section: Cytotoxicity and Lipophilicity Of 1–5mentioning
Shine a light: A ruthenium tris(bipyridyl) complex that was originally designed as a photosensitizer for solar cells has been found to adhere to plasma membranes.
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