Localization and effects of neuropeptide Y, vasoactive intestinal polypeptide, substance P, and calcitonin gene–related peptide in human temporal arteries

Jansen, I.; Uddman, Rolf; Hocherman, M; Ekman, Rolf; Jensen, Kai; Olesen, Jes; Stiernholm, P; Edvinsson, Lars

doi:10.1002/ana.410200409

Cited by 89 publications

(39 citation statements)

References 16 publications

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“…19 CGRP is present in perivascular trigeminal-nerve fibers that supply the pial arteries, the meningeal arteries, 20 and the extracranial cephalic arteries. 21 Stimulation of the trigeminal ganglion in humans and cats 22 and electrical stimulation of the superior sagittal sinus in animals 23,24 induce the release of CGRP into the cranial circulation. During spontaneous migraine attacks, the level of CGRP is increased in blood from the external jugular vein, which drains the extracranial compartment.…”

Section: Tolerability and Safetymentioning

confidence: 99%

Calcitonin Gene–Related Peptide Receptor Antagonist BIBN 4096 BS for the Acute Treatment of Migraine

et al. 2004

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Section: Tolerability and Safetymentioning

confidence: 99%

Calcitonin Gene–Related Peptide Receptor Antagonist BIBN 4096 BS for the Acute Treatment of Migraine

et al. 2004

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“…10 Nerve-induced dilation of PA has not been recorded in any animal species (see for example reference 12), although this is the dominant response in the proximal cerebral arteries of the cat 39 and pig. 41 A variety of dilator nerves have been visualized using different techniques in a number of species [42][43][44] : those containing ACh, 42,43 neuropeptide Y, vasoactive intestinal peptide, substance P, calcitonin gene-related peptide, [43][44][45] and NO. 46 Evidence for a functional role for some of these dilator neurotransmitters in nonhuman arteries has been reviewed.…”

Section: Discussionmentioning

confidence: 99%

Weakness of Sympathetic Neural Control of Human Pial Compared With Superficial Temporal Arteries Reflects Low Innervation Density and Poor Sympathetic Responsiveness

Bevan

Dodge²,

Nichols³

et al. 1998

Stroke

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Background and Purpose-The primary goal of these studies was to understand and investigate the capacity of perivascular nerves to influence the tone of human pial arteries and to compare them with other human cephalic arteries, the superficial temporal and middle meningeal. Methods-Responses to electrical activation of intramural nerves and related features of fresh segments of human cephalic arteries-the pial (PA; 478Ϯ34 m ID), middle meningeal (MMA; 540Ϯ41 m ID), and superficial temporal (STA; 639Ϯ49 m ID)-obtained from patients aged 15 to 82 years during surgical procedures were studied on a resistance artery myograph. Results-The PA segment responses to electrical nerve activation and to norepinephrine (NE; 10 Ϫ5 mol/L) were 1% and 21% of tissue maximum, respectively, compared with 6% and 34% for the MMA and 14% and 90% for the STA. Tissue maximum was defined as the force increase to 127 mmol/L KCl plus arginine vasopressin (1 m). All arteries dilated well to acetylcholine. Possible explanations for the PA marginal neurogenic responses were assessed. NE ED 50 was 5.4Ϯ2.2ϫ10Ϫ7 mol/L and did not vary with age or diameter. NE responsiveness did not increase in vessels with spontaneous or raised potassium-induced tone. Relaxation to isoproterenol was variable and propranolol did not increase the neurogenic response. Neither N G -monomethyl-L-arginine, N G -nitro-L-arginine methyl ester, endothelium removal, nor indomethacin consistently influenced the contractions to NE or neurogenic reactivity. The weak PA neurogenic response is in keeping with its poor innervation. As determined by catecholamine histofluorescence, innervation in the PA is sparse, with density increasing in the order PA, MMA, and STA. The incidence of nerve structures in the PA adventitio-medial junction was only 3% of those in the STA, and these were situated more than 3 m from the closest smooth muscle cell. Conclusions-We conclude that the weak neurogenic response of adult human pial artery reflects its poor innervation and responsiveness to NE, implying that these features are not important in the regulation of its diameter. (Stroke. 1998;29:212-221.)

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“…The dura and its attendant blood vessels are innervated by trigeminal and upper cervical sensory nerve fibres which contain the vasoactive peptides, SP, NKA and CGRP (Edvinsson & Uddman, 1982;Mayberg et al, 1984;Jansen et al, 1986;Saito et al, 1987). Perivascular sensory axons are unmyelinated and small and reside within the adventitial layer.…”

Section: Introductionmentioning

confidence: 99%

The antimigraine drug, sumatriptan (GR43175), selectively blocks neurogenic plasma extravasation from blood vessels in dura mater

Buzzi

Moskowitz

1990

British J Pharmacology

404

192

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1We describe the actions of GR43175, a 5-hydroxytryptamine1 (5-HT,)-like receptor agonist, on neurogenically-mediated plasma protein extravasation within an important pain-sensitive intracranial tissue, the dura mater. 2 GR43175 markedly attenuated extravasation of '25I-albumin from blood vessels within ipsilateral dura mater when administered to rats (100 pgkg-1) fifteen minutes before unilateral electrical trigeminal stimulation (1.2 mA, 5Hz, Sims, S min.); the ratio (stimulated/unstimulated sides) decreased from 1.81 to 1.23, P < 0.005).3 GR43175 (l00pgkg-1, i.v., rats; 30pgkg-, i.v., guinea-pigs) decreased the leakage of radiolabelled albumin from 163% to 119% (P < 0.005, guinea-pig) or from 174 to 118% (P < 0.05, rat) above vehicletreated controls when injected ten minutes before systemic capsaicin treatment (0.5 or 1 umol kg-1, i.v.).4 GR43175 (30-300pgkg-1) did not block plasma protein extravasation within extracranial tissues of rats and guinea-pigs innervated by the trigeminal nerve (conjunctiva, eyelid and lip).5 The protein leakage which followed the i.v. administration of 5-HT (1 ymol kg 1) or neuropeptides which mediate neurogenic plasma extravasation, substance P (0.3 nmol kg-1 or 1 nmol kg 1) and neurokinin A (1 nmol kg-'), was not blocked by GR43175 (100, 300pgkg-1) despite the presence of leakage in amounts equivalent to that following neurogenic stimulation.6 GR43175 (l00gkg-1) decreased bradykinin (1Opmolkg-')-induced extravasation from 142 to 115% above vehicle-treated animals (P < 0.05). 7 These results demonstrate an important action of GR43175 on neurogenic mechanisms in dural blood vessels. Since the ergot alkaloids possess a similar profile of drug activity, it is suggested that drugs useful in the treatment of acute vascular headaches may share a similar mechanism of action.

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Localization and effects of neuropeptide Y, vasoactive intestinal polypeptide, substance P, and calcitonin gene–related peptide in human temporal arteries

Cited by 89 publications

References 16 publications

Calcitonin Gene–Related Peptide Receptor Antagonist BIBN 4096 BS for the Acute Treatment of Migraine

Calcitonin Gene–Related Peptide Receptor Antagonist BIBN 4096 BS for the Acute Treatment of Migraine

Weakness of Sympathetic Neural Control of Human Pial Compared With Superficial Temporal Arteries Reflects Low Innervation Density and Poor Sympathetic Responsiveness

The antimigraine drug, sumatriptan (GR43175), selectively blocks neurogenic plasma extravasation from blood vessels in dura mater

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