Localization and Regulation of Glucocorticoid and Mineralocorticoid Receptor Messenger RNAs in the Hippocampal Formation of the Rat

Herman, James P.; Patel, Paresh D.; Akil, Huda; Watson, Stanley J.

doi:10.1210/mend-3-11-1886

Cited by 316 publications

(184 citation statements)

References 21 publications

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“…Using diffusion weighted imaging to measure structural reorganization of the human brain, they reported significant positive association between fractional anisotropy (measure of restricted diffusion thought to reflect tissue integrity) in bilateral hippocampal structure and estrogen (Barth et al, 2016). In addition, enzymes for estrogen synthesis and estrogen receptor messenger RNA (mRNA) have been localized to the hippocampus (Fester et al, 2011;Herman et al, 1989), whereas androgen receptors are more prevalent in the amygdala (McGinnis et al, 1996). Taken together, the coincident changes in memory performance and menstrual phase reported here and elsewhere are likely related to structural underpinnings that require further investigation.…”

Section: Discussionmentioning

confidence: 99%

The effect of sex and menstrual phase on memory formation during a nap

Sattari

McDevitt

Panas

et al. 2017

Neurobiology of Learning and Memory

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Memory formation can be influenced by sleep and sex hormones in both men and women, and by the menstrual cycle in women. Though many studies have shown that sleep benefits the consolidation of memories, it is not clear whether this effect differs between men and women in general or according to menstrual phase in women. The present study investigated the effect of sex and menstrual cycle on memory consolidation of face-name associations (FNA) following a daytime nap. Recognition memory was tested using a face-name paired associates task with a polysomnographic nap between morning and evening testing. Seventeen healthy women (age: 20.75 (1.98) years) were studied at two time points of their menstrual cycles, defined from self-report and separated by 2 weeks (perimenses: -5 days to + 6 days from the start of menses, and non-perimenses: outside of the perimenses phase) and compared with eighteen healthy men (age: 22.01 (2.91) years). Regardless of menstrual phase, women had better pre-nap performance than men. Further, menstrual phase affected post-nap memory consolidation, with women showing greater forgetting in their perimenses phase compared with their nonperimenses phase, and men. Interestingly, post-nap performance correlated with electrophysiological events during sleep (slow oscillations, spindles, and temporal coupling between the two), however, these correlations differed according to menstrual phase and sex.Men's performance improvement was associated with the temporal coupling of spindles and slow oscillations (i.e., spindle/SO coincidence) as well as spindles. Women, however, showed an association with slow oscillations during non-perimenses, whereas when they were in their perimenses phase of their cycle, women appeared to show an association only with sleep spindle events for consolidation. These findings add to the growing literature demonstrating sex and menstrual phase effects on memory formation during sleep. THE EFFECT OF SEX AND MENSTRUAL CYCLE ON MEMORY 3

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Section: Discussionmentioning

confidence: 99%

The effect of sex and menstrual phase on memory formation during a nap

Sattari

McDevitt

Panas

et al. 2017

Neurobiology of Learning and Memory

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“…The reasons for this subfIeld selectivity are unclear. However, it may be relevant that the highest levels of GR expression within the hippocampus are evident within CAl and dentate gyrus (Herman et al 1989a), perhaps making these subregions more sensi tive to glucocorticoids. Alternatively, it remains possible that 5-HT 1A receptors possess differential transcrip tional/translational efficiencies with respect to hippo campal subflelds.…”

Section: Discussionmentioning

confidence: 99%

“…In situ hybridization histochemistry has confIrmed the intra hippocampal synthesis of these sites and provided a clear picture of their respective distributions across hip pocampal subfIelds (Herman et al 1989a;). …”

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confidence: 99%

Regulation of Hippocampal 5-HT1A Receptor Gene Expression by Dexamethasone

Chalmers

López

Vázquez

et al. 1994

Neuropsychopharmacol

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The effect of dexamethasone, a selective GR agonist, on hippocampal, 5-HT1A receptor mRNA expression and 5-HT1A binding was examined using in situ hybridization histochemistry and in vitro receptor autoradiography. One week after adrenalectomy, both 5-HT1A receptor mRNA expression and 5-HT1A binding were increased throughout the hippocampus. Administration of dexamethasone at the time of adrenalectomy significantly attenuated the increases in 5-HT1A mRNA expression in all hippocampal subfields (p < . OS, Fisher Test), although 5-HT1A mRNA levels

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“…The hippocampus is well known to be influenced by stress, and increases in noradrenaline have been demonstrated consistently in the hippocampus in response to stress (Tanaka et al, 1983;Nisenbaum et al, 1991). In addition, the hippocampal formation expresses high levels of both MR (or type I corticosteroid receptor) and GR (or type II corticosteroid receptor) (Reul and de Kloet, 1985;Herman et al, 1989), making this a region that is highly susceptible to changes in circulating glucocorticoids (McEwen, 2007). The noradrenergic system appears to interact closely with corticosteroid receptors, with lesions of the ascending noradrenergic pathways leading to increased MR binding in the hippocampus and attenuated corticosterone responses to stress, suggestive of an indirect role for the noradrenergic system in glucocorticoid negative feedback (Maccari et al, 1990;Maccari et al, 1992).…”

Section: Discussionmentioning

confidence: 99%

“…It is also an area that expresses high levels of both mineralocorticoid (MR) and glucocorticoid (GR) receptors (Reul and de Kloet, 1985;Herman et al, 1989), and is strongly influenced by circulating glucocorticoids (McEwen, 2007). Considerable evidence supports a close interaction between glucocorticoids and the noradrenergic system in the hippocampus.…”

Section: Introductionmentioning

confidence: 99%

Regulation of hippocampal α1d adrenergic receptor mRNA by corticosterone in adrenalectomized rats

et al. 2008

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The hippocampal formation receives extensive noradrenergic projections and expresses high levels of mineralocorticoid (MR) and glucocorticoid (GR) receptors. Considerable evidence suggests that the noradrenergic system influences hippocampal corticosteroid receptors. However, there is relatively little data describing the influence of glucocorticoids on noradrenergic receptors in the hippocampal formation. α 1d adrenergic receptor (ADR) mRNA is expressed at high levels in the hippocampal formation, within cells that express MR or GR. In order to determine whether expression of α 1d ADR mRNA is influenced by circulating glucocorticoids, male rats underwent bilateral adrenalectomy (ADX) or sham surgery, and were killed after 1, 3, 7 or 14 days. Levels of α 1d ADR mRNA were profoundly decreased in hippocampal subfields CA1, CA2 and CA3 and the medial and lateral blades of the dentate gyrus, as early as 1 day after ADX, as determined by in situ hybridization. The effect was specific for the hippocampal formation, with levels of α 1d mRNA unaltered by ADX in the lateral amygdala, reticular thalamic nucleus, retrosplenial cortex or primary somatosensory cortex. Additional rats underwent ADX or sham surgery and received a corticosterone pellet (10 or 50 mg) or placebo for 7 days. Corticosterone replacement prevented the ADX-induced decrease in hippocampal α 1d ADR mRNA, with the magnitude of effect depending on corticosterone dose and hippocampal subregion. These data indicate that α 1d ADR mRNA expression in the hippocampal formation is highly sensitive to circulating levels of corticosterone, and provides further evidence for a close interaction between glucocorticoids and the noradrenergic system in the hippocampus.

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Localization and Regulation of Glucocorticoid and Mineralocorticoid Receptor Messenger RNAs in the Hippocampal Formation of the Rat

Cited by 316 publications

References 21 publications

The effect of sex and menstrual phase on memory formation during a nap

The effect of sex and menstrual phase on memory formation during a nap

Regulation of Hippocampal 5-HT1A Receptor Gene Expression by Dexamethasone

Regulation of hippocampal α1d adrenergic receptor mRNA by corticosterone in adrenalectomized rats

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