Localization of 8-Methoxypsoralen in Ocular Tissues

Lerman, Sidney; Megaw, Judith M.; Gardner, K; Takei, Yo‐ichi; Willis, Isaac

doi:10.1159/000265138

Cited by 17 publications

(6 citation statements)

References 6 publications

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“…Experimental studies have demonstrated that methoxsalen is capable of entering ocular tissues, including the crystalline lens (Lerman et al 1980). Theoretically, the photosensitising of the lens fibres induced by methoxsalen could promote the development of cataracts.…”

Section: Methoxsalen (8-methoxypsoralen)mentioning

confidence: 99%

Clinically Important Ocular Reactions to Systemic Drug Therapy

Rennie

1993

Drug Safety

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Many systemically administered drugs produce ocular adverse effects. Fortunately, relatively few are capable of causing significant, irreversible visual impairment. It is the responsibility of every clinician when prescribing systemic therapeutic agents to be aware of potential adverse ocular reactions, to appreciate their significance, and to inform the patient of the potential risks of treatment. In instances where serious adverse reactions relate to the cumulative effects of prolonged treatment, it is the responsibility of the prescribing physician to institute appropriate methods of visual screening. In this respect, it is most important to obtain the necessary individual baseline measurements before treatment is commenced. Chloroquine retinopathy is probably the most feared of all adverse ocular reactions to systemic drug therapy. However, it occurs only rarely if the daily dosage of chloroquine does not exceed 250mg. Regular screening using automated perimetry is mandatory if prolonged therapy is contemplated. Amiodarone almost inevitably produces corneal deposits. These rarely produce symptoms, and resolve upon withdrawal of the drug. Optic neuropathy has recently been described with amiodarone. Systemic anticoagulant therapy may be associated with intraocular hemorrhage in patients with pre-existing disciform macular degeneration, and such agents should be used with caution in affected individuals. Systemic corticosteroids produce posterior subcapsular cataracts in susceptible individuals which may profoundly affect visual acuity. Although elevated intraocular pressure may also result from systemic therapy, the relationship between the pressure rise and development of glaucomatous changes remains unclear. Ethambutol may produce optic neuropathy if the daily dosage exceeds 15 mg/kg. The changes are usually reversible within a few weeks of stopping treatment. High doses of tamoxifen may produce a maculopathy with loss of visual acuity, if given for prolonged periods. The risk must be weighed against the benefits of treatment. Patients receiving more than 800 mg/day of thioridazine have developed retinopathy, which is usually reversible if detected early enough. Tricyclic antidepressants and other agents with anticholinergic properties may cause disturbances of accommodation and pupillary dilatation. The latter may rarely precipitate acute angle closure glaucoma in susceptible individuals.

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Section: Methoxsalen (8-methoxypsoralen)mentioning

confidence: 99%

Clinically Important Ocular Reactions to Systemic Drug Therapy

Rennie

1993

Drug Safety

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“…By the 3rd to 4th decade there is a significant level of 440 nm fluorescence while the longer wavelength fluorescence emission requires an additional decade before it shows a similar enhancement [10,11,13,15]. These changes can also be induced and accelerated by in vitro exposure of normal lenses to mono chromatic 300 nm UV radiation [12,17,18]. UV slit lamp densitography measurements on patients whose lenses were judged normal by conven- Fig.…”

mentioning

confidence: 99%

In vivo Lens Fluorescence Photography

1981

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We are reporting a new, objective and quantitative method for monitoring age-related molecular changes in the human ocular lens in vivo, as expressed by increases in at least two (nontryptophan) fluorescence wavelengths. These data correlate with previously reported in vitro lens fluorescence changes which are associated with the aging process. This method will also detect alterations in lenticular fluorescence caused by photosensitized as well as direct ultraviolet radiation damage.

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“…8-MOP had been demonstrated in the lens of the enucleated eye of a patient who was given 0.75 mg 8-MOP per kg body weight 12 hours before the enucleation (Lerman et al, 1980). Lerman has also found 8-MOP in the lens in rats and seals (Lerman et al, 1981); this was possible up to 24 hours after administration. If the animals were also exposed to UV-A light, 8-MOP was still demonstrable in the lens 3 weeks later.…”

Section: Discussionmentioning

confidence: 97%