Localization of Advanced Glycation End Products of Maillard Reaction in Bovine Tissues and Their Endocytosis by Macrophage Scavenger Receptors

Mori, Takashi; Takahashi, Kiyoshi; Higashi, Takayuki; Takeya, Motohiro; Kume, Shuichi; Kawabe, Yojiro; Kodama, Tatsuhiko; Horiuchi, Seikoh

doi:10.1006/exmp.1995.1038

Cited by 15 publications

(6 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These data are supportive of the work by Cantin et al, demonstrating that albumin increases intracellular GSH, likely due to its endocytosis, degradation, and the utilization of its 34 cysteines [42]. Cells can internalize glycated albumin [43], suggesting that the GSH concentration differences between cells treated with BSA and AGE-BSA is not due exclusively to diminished biosynthesis. However, it is unclear if this process is affected by SH-SY5Y, so we will study this mechanism in our cells.…”

Section: Discussionsupporting

confidence: 87%

The Antioxidant 3H-1,2-Dithiole-3-Thione Potentiates Advanced Glycation End-Product-Induced Oxidative Stress in SH-SY5Y Cells

Pazdro

Burgess

2012

Experimental Diabetes Research

View full text Add to dashboard Cite

Oxidative stress is implicated as a major factor in the development of diabetes complications and is caused in part by advanced glycation end products (AGEs). AGEs ligate to the receptor for AGEs (RAGE), promoting protein kinase C (PKC)-dependent activation of nicotinamide adenine dinucleotide phosphate (NADPH) oxidase and superoxide radical generation. While scavenging antioxidants are protective against AGEs, it is unknown if induction of endogenous antioxidant defenses has the same effect. In this study, we confirmed that the compound 3H-1,2-dithiole-3-thione (D3T) increases reduced-state glutathione (GSH) concentrations and NADPH:quinone oxidoreductase 1 (NQO1) activity in SH-SY5Y cells and provides protection against H2O2. Surprisingly, D3T potentiated oxidative damage caused by AGEs. In comparison to vehicle controls, D3T caused greater AGE-induced cytotoxicity and depletion of intracellular GSH levels while offering no protection against neurite degeneration or protein carbonylation. D3T potentiated AGE-induced reactive oxygen species (ROS) formation, an effect abrogated by inhibitors of PKC and NADPH oxidase. This study suggests that chemical induction of endogenous antioxidant defenses requires further examination in models of diabetes.

show abstract

Section: Discussionsupporting

confidence: 87%

The Antioxidant 3H-1,2-Dithiole-3-Thione Potentiates Advanced Glycation End-Product-Induced Oxidative Stress in SH-SY5Y Cells

Pazdro

Burgess

2012

Experimental Diabetes Research

View full text Add to dashboard Cite

show abstract

“…In addition, the elimination of C. parvum by Kupffer cells and monocyte-derived macrophages from the liver of homozygous mutant mice was delayed, and the bacteria remained longer in macrophages, mainly within the hepatic granulomas, compared with the situation in the wild-type mice. Because several types of scavenger receptors besides type I and type II MSR-A are also known, [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18] we examined the expression of MARCO receptor, macrosialin/CD68, Fc␥ receptor II-B2, and CD36 in the process of the hepatic granuloma formation in homozygous mutant mice and demonstrated the immunohistochemical expression of these proteins and/or their expression at the message level. Among these membrane proteins, MARCO is in the same class as type I and type II MSR-A and is known to be deeply involved in the uptake of bacterial antigens and neutral polysaccharides, and it is expressed in marginal zone macrophages in the spleen and macrophages in lymphatic sinuses of lymph nodes, but not in other tissues, including the liver, in unstimulated normal mice.…”

Section: Discussionmentioning

confidence: 99%

Role of Macrophage Scavenger Receptors in Hepatic Granuloma Formation in Mice

Hagiwara

Takeya

Suzuki³

et al. 1999

The American Journal of Pathology

Self Cite

View full text Add to dashboard Cite

“…These AGEs are taken up by cells through SRA pathways. [52][53][54][55][56] El Khoury et al 57 showed that macrophages can adhere to surfaces coated with glucose-modified basement membrane collagen IV through their SRAs. These findings indicate a potential role of SRA in the accelerated atherogenesis found in diabetes; ie, SRA promotes the adhesion of macrophages to glucosemodified basement membrane proteins in the arterial wall.…”

Section: Sra In Adhesion and Cell-cell Contactmentioning

confidence: 99%

Macrophage Scavenger Receptor Class A

Winther

Dijk

Havekes

et al. 2000

ATVB

214

101

View full text Add to dashboard Cite

Abstract-In atherogenesis, elevated plasma levels of low density lipoprotein (LDL) lead to the chronic presence of LDL in the arterial wall. There, LDL is modified (eg, oxidized), and these modified lipoproteins activate endothelial cells, which attract circulating monocytes. These monocytes enter the vessel wall, differentiate into macrophages, and subject the modified lipoproteins to endocytosis through scavenger receptor pathways. This unrestricted uptake, which is not limited by intracellular cholesterol levels, eventually leads to the formation of lipid-filled foam cells, the initial step in atherosclerosis. Macrophage scavenger receptor class A (SRA) is thought to be one of the main receptors involved in foam cell formation, mediating the influx of lipids into the macrophages. In addition to this role in modified lipoprotein uptake by macrophages, the SRA has been shown to be important in the inflammatory response in host defense, cellular activation, adhesion, and cell-cell interaction. Given the importance of these processes in atherogenesis, these latter functions may prove to make the SRA a multifunctional player in the atherosclerotic process.

show abstract

Localization of Advanced Glycation End Products of Maillard Reaction in Bovine Tissues and Their Endocytosis by Macrophage Scavenger Receptors

Cited by 15 publications

References 0 publications

The Antioxidant 3H-1,2-Dithiole-3-Thione Potentiates Advanced Glycation End-Product-Induced Oxidative Stress in SH-SY5Y Cells

The Antioxidant 3H-1,2-Dithiole-3-Thione Potentiates Advanced Glycation End-Product-Induced Oxidative Stress in SH-SY5Y Cells

Role of Macrophage Scavenger Receptors in Hepatic Granuloma Formation in Mice

Macrophage Scavenger Receptor Class A

Contact Info

Product

Resources

About