Localization of angiotensin II in pig ovary and its effects on oocyte maturation in vitro

Li, Y. H.; Jiao, Li-Hong; Liu, R. H.; Chen, X. L.; Wang, Hongran; Wang, W. H.

doi:10.1016/s0093-691x(03)00246-2

Cited by 27 publications

(22 citation statements)

References 19 publications

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“…In the same study, similar negative effects on follicle development were observed after Ang II infusion in wild-type females. In swine, the concentrations of Ang II in follicular fluid were found to be negatively correlated with follicular diameter (Li et al 2004). These studies indicate the existence of marked species differences of the RAS function in follicle development and atresia.…”

Section: Ang II Signaling: Studies In Vivo and In Vitromentioning

confidence: 64%

Role of angiotensin in ovarian follicular development and ovulation in mammals: a review of recent advances

Gonçalves¹,

Ferreira²,

Gasperin³

et al. 2012

Reproduction

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Angiotensin (Ang) II is widely known for its role in the control of systemic blood vessels. Moreover, Ang II acts on the vascular control of ovarian function, corpus luteum formation, and luteolysis. Over the past 10 years, our research group has been studying the new concept of the renin-angiotensin system (RAS) as an autocrine/paracrine factor regulating steroidogenesis and promoting different cellular responses in the ovary, beyond vascular function. We have developed and used different in vivo and in vitro experimental models to study the role of RAS in the ovary and a brief overview of our findings is presented here. It is widely accepted that there are marked species differences in RAS function in follicle development. Examples of species-specific functions of the RAS in the ovary include the involvement of Ang II in the regulation of follicle atresia in rats vs the requirement of this peptide for the dominant follicle development and ovulation in rabbits and cattle. More recently, Ang-(1-7), its receptor, and enzymes for its synthesis (ACE2, NEP, and PEP) were identified in bovine follicles, implying that Ang-(1-7) has an ovarian function. Other novel RAS components (e.g. (pro)renin receptor and renin-binding protein) recently identified in the bovine ovary show that ovarian RAS is poorly understood and more complex than previously thought. In the present review, we have highlighted the progress toward understanding the paracrine and autocrine control of ovarian antral follicle development and ovulation by ovarian tissue RAS, focusing on in vivo studies using cattle as a model.

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Section: Ang II Signaling: Studies In Vivo and In Vitromentioning

confidence: 64%

Role of angiotensin in ovarian follicular development and ovulation in mammals: a review of recent advances

Gonçalves¹,

Ferreira²,

Gasperin³

et al. 2012

Reproduction

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“…The renin -angiotensin system in the kidney regulates systemic blood pressure and fluid homeostasis. There are data supporting the idea that the reninangiotensin system also exerts an influence in the ovary playing a role in follicular development, steroidogenesis, oocyte maturation, ovulation and follicle atresia (Yoshimura 1997, Li et al 2004), and that this system is regulated by gonadotrophins (Kuji et al 1996). It is, therefore, possible that the renal renin -angiotensin system affects follicle development and oocyte maturation in ovarian grafts placed on the kidney.…”

Section: Discussionmentioning

confidence: 97%

Graft site and gonadotrophin stimulation influences the number and quality of oocytes from murine ovarian tissue grafts

Yang¹,

Cox²,

Jenkin³

et al. 2006

Reproduction

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Ovarian tissue cryopreservation and subsequent transplantation can restore fertility in cancer patients. This study used a mouse ovarian grafting model to investigate whether the graft site (bursal cavity, the kidney capsule or subcutaneous) influences the number, fertilization rate and developmental potential of oocytes recovered from grafts and whether using a standard gonadotrophin stimulation protocol would increase oocyte yield from the grafts. Mouse ovarian tissue was grafted into four week old mice and collected three weeks later. Graft recipients were treated either with or without exogenous gonadotrophin stimulation prior to graft collection. Grafted ovaries yielded oocytes that were either at the germinal vesicle (GV) stage or mature metaphase II (MII) stage at collection. These GV oocytes were matured before in vitro fertilization (IVF), while the MII oocytes underwent IVF immediately. Oocytes collected from the oviducts of non-grafted superovulated mice of the same age served as controls. Two-cell embryos were transferred to pseudopregnant recipients and recovered at day 15 of gestation or left to go to term. Graft retrieval and the number of oocytes from each graft were lowest from the subcutaneous graft site. The number of two-cell embryos produced was significantly higher for oocytes from the grafts to the bursa as compared with the other sites. All graft sites gave rise to embryos with comparable implantation rates and developmental potential to fetuses and offspring following transfer. However, the oocytes from grafted ovaries had a significantly lower developmental potential when compared with the control group. Stimulation with exogenous gonadotrophins did not significantly increase oocyte yield from grafted ovaries but did enhance oocyte maturation and development. In conclusion, graft site affects the number and quality of oocytes produced from ovarian grafts.

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“…That many organ systems contain discrete RASs has been well understood for some time: such localised systems have been described in many tissues, including the kidney, liver and adrenal (Phillips et al 1993, Gupta et al 1995, Zimmerman & Dunham 1997, Mulrow 1998, Vinson & Ho 1998, Neo et al 2010), brain, pituitary and reproductive system (Hagemann et al 1994, Ganong 1995, Nielsen et al 1995, Vila-Porcile & Corvol 1998, McKinley et al 2003, Li et al 2004, Dean et al 2006, pancreas (Tahmasebi et al 1999, Leung & Carlsson 2001, 2005, Lau & Leung 2011), lung (Feng et al 2010) and heart (Okura et al 1992, Bader 2002, Dean et al 2006.…”

Section: The Local Ras In the Breast Tissue Remodelling And Matrix Mementioning

confidence: 99%

The renin–angiotensin system in the breast and breast cancer

Vinson¹,

Barker²,

Puddefoot³

2011

Endocrine-Related Cancer

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Much evidence now suggests that angiotensin II has roles in normal functions of the breast that may be altered or attenuated in cancer. Both angiotensin type 1 (AT1) and type 2 (AT2) receptors are present particularly in the secretory epithelium. Additionally, all the elements of a tissue renin-angiotensin system, angiotensinogen, prorenin and angiotensin-converting enzyme (ACE), are also present and distributed in different cell types in a manner suggesting a close relationship with sites of angiotensin II activity. These findings are consistent with the concept that stromal elements and myoepithelium are instrumental in maintaining normal epithelial structure and function. In disease, this system becomes disrupted, particularly in invasive carcinoma. Both AT1 and AT2 receptors are present in tumours and may be up-regulated in some. Experimentally, angiotensin II, acting via the AT1 receptor, increases tumour cell proliferation and angiogenesis, both these are inhibited by blocking its production or function. Epidemiological evidence on the effect of expression levels of ACE or the distribution of ACE or AT1 receptor variants in many types of cancer gives indirect support to these concepts. It is possible that there is a case for the therapeutic use of high doses of ACE inhibitors and AT1 receptor blockers in breast cancer, as there may be for AT2 receptor agonists, though this awaits full investigation. Attention is drawn to the possibility of blocking specific AT1-mediated intracellular signalling pathways, for example by AT1-directed antibodies, which exploit the possibility that the extracellular N-terminus of the AT1 receptor may have previously unsuspected signalling roles.

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Localization of angiotensin II in pig ovary and its effects on oocyte maturation in vitro

Cited by 27 publications

References 19 publications

Role of angiotensin in ovarian follicular development and ovulation in mammals: a review of recent advances

Role of angiotensin in ovarian follicular development and ovulation in mammals: a review of recent advances

Graft site and gonadotrophin stimulation influences the number and quality of oocytes from murine ovarian tissue grafts

The renin–angiotensin system in the breast and breast cancer

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