Localization of brain damage in mice following<i>Toxoplasma</i>infection

Hay, J.; Hair, D. M.; Graham, David I.

doi:10.1080/00034983.1984.11811878

Cited by 5 publications

(2 citation statements)

References 6 publications

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“…Many studies have primarily examined the behavioral and pathological effects of congenital infection [27, 28], and few studies have included behavioral assays in multiple behavioral domains. Furthermore, the parasite load, anatomical location of parasite stages and behavioral outcomes change during the course of the infection [29, 30] and interpretations of behavioral outcomes in the acute phase of infection are complicated by the high levels of tachyzoites in critical peripheral tissues, such as muscle, heart and lungs.…”

Section: Introductionmentioning

confidence: 99%

Acquired infection with Toxoplasma gondii in adult mice results in sensorimotor deficits but normal cognitive behavior despite widespread brain pathology

Gulinello

Acquarone

Kim

et al. 2010

Microbes and Infection

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Toxoplasma gondii is a ubiquitous intracellular parasite which chronically infects 30 to 50% of the human population. While acquired infection is primarily asymptomatic several studies have suggested that such infections may contribute to neurological and psychiatric symptoms. Previous studies in rodents have demonstated that T. gondii infection does not just kill its host, but alters the behavioral repertoire of an infected animal making it more likely that predation with occur completing the parasite life cycle. The aim of the present study was to evaluate the behavioral changes in C57BL/ 6 mice chronically infected with the avirulent T. gondii (ME49, a type II strain), in a comprehensive test battery. Infected mice demonstrated profound and widespread brain pathology, motor coordination and sensory deficits. In contrast, cognitive function, anxiety levels, social behavior and the motivation to explore novel objects were normal. The observed changes in behavior did not represent "gross" brain damage or dysfunction and were not due to targeted destruction of specific areas of the brain. Such changes point out the subtle interaction of this parasite with its intermediate hosts and are consistent with ideas about increased predation being an outcome of infection.

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Section: Introductionmentioning

confidence: 99%

Acquired infection with Toxoplasma gondii in adult mice results in sensorimotor deficits but normal cognitive behavior despite widespread brain pathology

Gulinello

Acquarone

Kim

et al. 2010

Microbes and Infection

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“…221). In murine hosts, many authors have described a predilection of the parasite for the gray matter and, more specifically, for the neocortex (Verma and Bowles 1967;Uga et al 1980), the deep gray matter, and the brain stem (Sasaki et al 1981;Hay et al 1984). Lymphocytic or lymphoplasmacytic infiltrates distend the subarachnoid space and the Virchow-Robin spaces of adjacent vessels.…”

Section: Icroscopic Featuresmentioning

confidence: 99%

Toxoplasmosis, Nervous System, Mouse and Hamster

Regan¹,

Shadduck²

1988

Nervous System

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The influence of congenitalToxoplasma infection on the spontaneous running activity of mice

1985

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Home-cage running-wheel activity of mice congenitally infected with Toxoplasma was recorded over 24 days. Infected mice were consistently more active than uninfected controls over the entire testing period. This finding extends previous studies and indicates that such increased activity levels occur not only in novel but also in familiar environments, and suggests that congenital toxoplasmosis tends to render mice "hyperactive'. If such behavioural alterations occur in wild mice, it is likely that infected mouse intermediate hosts would be more susceptible to predation by cats, the definitive hosts of Toxoplasma.

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Localization of brain damage in mice followingToxoplasmainfection

Cited by 5 publications

References 6 publications

Acquired infection with Toxoplasma gondii in adult mice results in sensorimotor deficits but normal cognitive behavior despite widespread brain pathology

Acquired infection with Toxoplasma gondii in adult mice results in sensorimotor deficits but normal cognitive behavior despite widespread brain pathology

Toxoplasmosis, Nervous System, Mouse and Hamster

The influence of congenitalToxoplasma infection on the spontaneous running activity of mice

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