Localization of chemical messengers in magnocellular neurons of the hypothalamic supraoptic and paraventricular nuclei: An immunohistochemical study using experimental manipulations

Meister, Björn; Villar, Marcelo J.; Ceccatelli, Sandra; Hökfelt, Tomas

doi:10.1016/0306-4522(90)90094-k

Cited by 182 publications

(120 citation statements)

References 160 publications

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“…In the PVN, intense prodynorphin mRNA expression is shown in the posterior PVN as well as the medial and lateral magnocellular part of the PVN. Co-localisation of dynorphin and oxytocin or vasopressin neurons in the magnocellular neurons of the PVN and SO has been reported (Meister et al, 1990), suggesting an important role for dynorphin in the control of prolactin secretion and water homeostasis. In addition, colocalisation of prodynorphin with two other neuropeptides (Cocaine and amphetamine regulated transcript and Orexin), which play an important role in the regulation of feeding behaviour, has been shown in the PVN and SON (Elias et al, 2001), as well as in the parvicellular neurons in the LH (Smart and Jerman, 2002).…”

Section: Discussionmentioning

confidence: 99%

Distribution of prodynorphin mRNA and its interaction with the NPY system in the mouse brain

et al. 2006

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Using radioactive in situ hybridisation, the distribution of prodynorphin mRNA in the brains of C57Bl/6 mice was systemically investigated, and double-labelling in situ hybridisation was used to determine the extent to which neuropeptide Y (NPY) and prodynorphin mRNAs were co-expressed. Our results demonstrate that prodynorphin mRNA expression in the mouse brain is localised at specific subregions of the olfactory bulb, cortex, hippocampus, amygdala, basal ganglia, thalamus, hypothalamus, mesencephalon and myelencephalon. Among the regions displaying the most intense labelling were the olfactory tubercle, lateral septum (LS), caudate putamen (Cpu), central amygdaloid nucleus (Ce), paraventricular hypothalamic nucleus (PVN), supraoptic nucleus (SO), lateral hypothalamic area (LHA), ventromedial hypothalamic nucleus (VMH), lateral reticular nucleus (LRt) and solitary tract nucleus (NTS). In the arcuate nucleus of the hypothalamus (Arc), doublelabelling in situ hybridisation revealed that prodynorphin expressing neurons also contained NPY mRNA, with a co-localisation rate of approximately 88% in the lateral part of the Arc, and 79% in the dorsal part of the Arc, respectively, suggesting potential overlapping functions of these two neurotransmitters in feeding type behaviour.

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Section: Discussionmentioning

confidence: 99%

Distribution of prodynorphin mRNA and its interaction with the NPY system in the mouse brain

et al. 2006

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“…Moreover, in the preoptic area, distributed are neurons containing hypothalamic releasing hormones, such as gonadotropin-releasing hormone (GnRH) (Amano et al, 1991) and corticotropin-releasing hormone (CRH) (Ando et al, 1999). Meister et al (1990) have demonstrated a small number of both vasopressin (VP) and oxytocin (OT) neurons colocalized with TRH in the rat paraventricular nucleus. VP has been shown to elicit release of TSH (Lumpin et al, 1987), indicating that this colocalization may be functional.…”

Section: Discussionmentioning

confidence: 99%

Localization of mRNA Encoding Thyrotropin-Releasing Hormone Precursor in the Brain of Sockeye Salmon

Ando

Urano

1998

Zoological Science

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ABSTRACT-The distribution of mRNA encoding thyrotropin-releasing hormone (TRH) precursor in the brain of sockeye salmon was studied by in situ hybridization histochemistry using digoxigenin-labeled riboprobes as a basis to investigate its physiological functions in the salmon brain. Since seasonal variation in TRH gene expression was expected in relation to smolting or maturation, fish were sampled in February and October. In both groups, TRH mRNA was widely distributed in discrete brain regions including the internal cellular layer (ICL) of the olfactory bulb, postcommissural nucleus of area ventralis telencephali (Vp), nucleus preopticus parvocellularis anterioris (PPa), nucleus preopticus magnocellularis, dorsal zone of periventricular hypothalamus (Hd), torus semicircularis, and also the motor nucleus of vagus nerve in the medulla oblongata. TRH neurons in ICL and Hd are round and small with diameters of 5-10 µm. In contrast, TRH neurons in the ventral telencephalon and the preoptic area are medium-sized (10-20 µm), and appear to have multiple processes. Most of these cells are restrictively localized along the lateral margin of the preoptic nuclei. The number of TRH neurons in Vp and PPa was smaller in February than in October, suggesting a seasonal change of TRH neurons in the preoptic area. In the medulla oblongata, a cluster of large oval-shaped cells (20-30 µm) showed signals for TRH mRNA. The present results suggest that TRH may function as a neurotransmitter or neuromodulator involved in olfactory activity and also autonomic motor integration, in addition to neurohormonal control of secretion of pituitary hormones.

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“…Specifically, some neurons in and around the periventricular zone may project to the area postrema, subfornical organ, or vascular organ of the lamina terminalis, and a small population of dopaminergic neurons outside the ARH that projects to the intermediate lobe of the pituitary was probably labeled [29], although the latter may be considered a special class of neuroendocrine motoneurons. And second, TH is clearly expressed is a subset of magnocellular neurosecretory vasopressinergic neurons in the PVH (and supraoptic nucleus) (see [16,32]). …”

Section: Methodological Considerationsmentioning

confidence: 99%

Spatiotemporal patterns of secretomotor neuron generation in the parvicellular neuroendocrine system 1Published on the World Wide Web on 3 June 1997. 1

Markakis

Swanson

1997

Brain Research Reviews

102

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Localization of chemical messengers in magnocellular neurons of the hypothalamic supraoptic and paraventricular nuclei: An immunohistochemical study using experimental manipulations

Cited by 182 publications

References 160 publications

Distribution of prodynorphin mRNA and its interaction with the NPY system in the mouse brain

Distribution of prodynorphin mRNA and its interaction with the NPY system in the mouse brain

Localization of mRNA Encoding Thyrotropin-Releasing Hormone Precursor in the Brain of Sockeye Salmon

Spatiotemporal patterns of secretomotor neuron generation in the parvicellular neuroendocrine system 1Published on the World Wide Web on 3 June 1997. 1

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