Localization of Glycosaminoglycans in Human and Canine Menisci and their Attachments

Adams, Mark E.; Ho, Yu

doi:10.3109/03008208709006981

Cited by 34 publications

(25 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…described diffcrenccs in glycosaminoglycan concentrations between the two menisci (1). Interestingly, the data of Adams and Ho showed that, compared with the lateral meniscus, the medial meniscus contained higher concentrations of total glycosaminoglycan and more hyaluronate and chondroitin sulfate glycosaminoglycans but less dermatan sulfate chains (1). Our data demonstrated that, compared with the lateral meniscus, the medial meniscus contained significantly higher levels of mRNA for versican.…”

Section: Discussionsupporting

confidence: 48%

“…in their study on meniscal composition in human knees. described diffcrenccs in glycosaminoglycan concentrations between the two menisci (1). Interestingly, the data of Adams and Ho showed that, compared with the lateral meniscus, the medial meniscus contained higher concentrations of total glycosaminoglycan and more hyaluronate and chondroitin sulfate glycosaminoglycans but less dermatan sulfate chains (1).…”

Section: Discussionmentioning

confidence: 99%

“…ovine. and human menisci is inhomogcneous (1,7,20,21,26). These studies indicate that the composition of the meniscus varies across its width (7,21,26).…”

Section: Discussionmentioning

confidence: 99%

“…Several studies have demonstrated that bovine, canine, ovine, and porcine meniscal tissue contains types T, IT, and 111 collagen (10,18) as well as large and small proteoglycans (1,19,23,26). However, except for Bland and Ashhurst (4), the investigators performed their studies on adult tissue.…”

Section: Discussionmentioning

confidence: 99%

“…In addition, menisci contain considerably less proteoglycan (4%) than does hyaline cartilage (7%) (6,ll). Ncverthcless, large chondroitin sulfate and sinall dermatan sulfate proteoglycans have been shown to be present in meniscal tissue (1,19,26).…”

mentioning

confidence: 99%

See 4 more Smart Citations

Gene expression in menisci from the knees of skeletally immature and mature female rabbits

Graverand

Reno

Hart

1999

Journal Orthopaedic Research

View full text Add to dashboard Cite

Summary: This study. using the sensitive molecular technique of semiquantitative reverse transcriptionpolymerase chain reaction. evaluated mRNA levels for several molecules in medial and lateral menisci from the knees of skeletally mature and immature rabbits. Total RNA was extracted from thc medial and latcral mcnisci of New Zealand White rabbits with the TRIspin method. Total RNA and DNA were similar in the two mcnisci ol both immaturc and mature rabbits. The total RNA was reverse-transcribed and analyzed by semiquantitative polymerase chain rcaction using rabbit-spccific primer sets; levels of mRNA for a subset of molecules differed between the medial and lateral menisci. These variations in mRNA levels were also influenced by the degree of skeletal maturity of the rabbits. For most ol the genes. mRNA levels were generally higher in the medial than in the lateral meniscus. Thc medial meniscus from immaturc and mature rabbits had significantly increased levels 01 mRNA Lor molecules such as transforming growth factor-p.cyclooxygenase-2, and tissue inhibitor of metalloprotcase-1. In contrast, compared with mRNA in the lateral meniscus. that for types I1 and I11 collagen, biglycan. insulin-like growth factor-2. plasminogen activator inhibitor-1, and matrix metalloprotease-l was significantly increased in the medial meniscus of mature rabbits only and that for versican and type-I collagen was significantly increased in the medial meniscus of immature rabbits only. Levels of tnRNA for inducible nitric oxide syiithase and basic fibroblast growth factor were similar in both menisci for both age groups. The present study demonstrates that regulation of mRNA levels in medial and lateral menisci is tissue-specific and influenced by the skeletal maturity of the animals.

show abstract

Section: Discussionsupporting

confidence: 48%

Section: Discussionmentioning

confidence: 99%

“…ovine. and human menisci is inhomogcneous (1,7,20,21,26). These studies indicate that the composition of the meniscus varies across its width (7,21,26).…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

See 3 more Smart Citations

Gene expression in menisci from the knees of skeletally immature and mature female rabbits

Graverand

Reno

Hart

1999

Journal Orthopaedic Research

View full text Add to dashboard Cite

show abstract

Meniscal Replacements

Donahue

Maes

2006

Wiley Encyclopedia of Biomedical Engineering

View full text Add to dashboard Cite

Menisci are fibrocartilagenous structures in the knee joint that act to distribute the load from the femur to the tibia. Menisci are frequently torn as a result of sporting activity or degenerative tears associated with aging. Approximately 12.5% of annual visits to orthopedic surgeons are related to knee injury, and of those visits, 43% are directly related to meniscal injuries (see review by McBride and Reid, 1988). Some tears do not heal because they either occur in the avascular region of the meniscus or are too complex for repair. Therefore, the common treatment for these types of tears is either complete or partial meniscectomy depending on the severity of the tear. However, meniscectomies have been shown to lead to degenerative arthritis in the knee. Therefore, in an effort to prevent premature arthritis caused by removal of the meniscus or a portion of the meniscus, meniscal replacement strategies are being investigated. This article will detail the basic structure and function of meniscal tissue and the attachments of the menisci to the surrounding structures. The strengths and weaknesses of various meniscal replacement strategies will be discussed, including autografts, meniscal allografts, synthetic prosthesis, and tissue‐engineered constructs. The success of meniscal replacements likely depends on their ability to restore normal meniscal function both biologically and biomechanically. Previous studies indicate that a number of biomechanical criteria are important for proper meniscal function, such as the material properties and geometry of the replacement tissue as well as the attachment of the replacement to the tibial plateau.

show abstract

Meniscal Structure and Function

Pozzi¹,

Cook²

2010

Advances in the Canine Cranial Cruciate Ligament

View full text Add to dashboard Cite

Localization of Glycosaminoglycans in Human and Canine Menisci and their Attachments

Cited by 34 publications

References 25 publications

Gene expression in menisci from the knees of skeletally immature and mature female rabbits

Gene expression in menisci from the knees of skeletally immature and mature female rabbits

Meniscal Replacements

Meniscal Structure and Function

Contact Info

Product

Resources

About