Localization of Intrarenal Cross-Linked Fibrin in Children with Various Renal Diseases

Kamitsuji, Hidekazu; Kusumoto, Kiyoaki; Taira, Koji; Iida, Yasuko; Nakajima, Mitsuru; Fukui, Hiromu

doi:10.1159/000183054

Cited by 6 publications

(2 citation statements)

References 7 publications

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“…Yoshioka et al [20] reported that the F XIII activity decreased in children with acute poststreptococcal glomerulonephritis, HSP nephritis and rapidly progressive glomerulonephritis. Kamitsuji et al [21] showed the deposition of F XIII in the glomeruli of children with various renal diseases including HSP nephritis. Decreased F XIII activity may thus result from the enhanced fibrin formation in the kidney [20].…”

Section: Discussionmentioning

confidence: 99%

Renal involvement in Henoch-Schönlein purpura: A multivariate analysis of prognostic factors

Kaku¹,

Nohara²,

Honda³

1998

Kidney International

184

147

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This study is the first report in which the relationship between the progression of renal involvement in Henoch-Schönlein purpura (HSP) and various factors was evaluated using a multivariate analysis. Sixty-five (33.5%) of 194 patients with HSP developed renal involvement from three days to 17 months after the onset of the disease. The plasma coagulation factor XIII (F XIII) activity of 97 patients was examined, and 51 (54.3%) of them showed a decreased activity. A univariate analysis showed that an age at the onset of more than seven years, persistent purpura and a decreased F XIII activity all increased the risk of developing renal involvement. A Cox regression model analysis indicated severe abdominal symptoms, persistent purpura and decreased F XIII activity to be significant risk factors and their hazard ratios were 3.26, 11.53 and 2.27, respectively. Corticosteroid treatment had a hazard ratio of 0.36 and was considered to decrease the risk of developing renal involvement. Based on these findings, patients who have the risk factors for renal involvement should be treated with corticosteroids at the onset of the disease to prevent developing renal involvement.

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Section: Discussionmentioning

confidence: 99%

Renal involvement in Henoch-Schönlein purpura: A multivariate analysis of prognostic factors

Kaku¹,

Nohara²,

Honda³

1998

Kidney International

184

147

View full text Add to dashboard Cite

show abstract

“…And substances released from platelets can be related to polymorphonuclear neutrophil migration, mesangial cell proliferation, complement activation, and increased permeability of the glomerular basement mem brane [10,20], Intraglomerular deposition of platelets, FRA and var ious coagulation factors has been identified in renal diseases [16][17][18]. Recent reports have described the intraglomerular deposition of FRA, F-XIIIa and F-XIlIs in GN and described the deposition of FRA, FDP-D and FDP-E in the glomeruli in GN [21][22][23]. In addition, Takemura et al [24] have shown the glomerular deposition of crosslinked Fibrin in renal diseases by using a mono clonal antibody that reacts with XL-FDP.…”

Section: Discussionmentioning

confidence: 99%

Intraglomerular Deposition of Coagulation-Fibrinolysis Factors and a Platelet Membrane Antigen in Various Glomerular Diseases

Deguchi

Tomura

Yoshiyama

et al. 1989

Nephron

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The intraglomerular location of coagulation-fibrinolysis factors (CFF) and a platelet membrane antigen (glycoprotein IIb-IIIa; GPIIb-IIIa) was determined in 101 patients with various glomerular diseases. Renal biopsy specimens were examined by immunofluorescence microscopy, using antisera against fibrinogen/fibrin reactive antigen (FRA), cross-linked fibrin degradation products (XL-FDP), fibronectin (FN), factor XIH-subunit a (F-XIIIa), plasminogen (Pig), α₂-plasmin inhibitor (α₂-PI) and GPIIb-IIIa. Intraglomerular deposits of the CFF were found at high rates in patients with IgA glomerulonephritis (GN), membranous nephropathy (MN) and lupus GN. The coexistence of deposits of these factors was ascertained by the double-staining method. The deposition rates of XL-FDP and GPIIb-IIIa were very low in patients with minimal-change nephrotic syndrome and focal glomerulosclerosis. Some cases of diabetic glomerulosclerosis (DGS) showed CFF deposition. FRA deposits associated with F-XIIIa and FN may indicate the presence of the cross-linked fibrin. Furthermore, the presence of Pig deposits together with α₂-PI and XL-FDP suggests the deposition of fibrin followed by fibrinolysis, but not of fibrinogen, and the coexistence of GPIIb-IIIa suggests the involvement of platelets in the reactions. These studies provide evidence that stabilized fibrin deposition with subsequent fibrinolysis and platelet activation take place in glomeruli in a fairly large proportion of patients with IgA GN, MN and lupus GN and in some cases of DGS.

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Haemolytic Uraemic Syndrome and Thrombotic Thrombocytopenic Purpura: A Review

Neild¹

1988

Platelet-Vessel Wall Interactions

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Localization of Intrarenal Cross-Linked Fibrin in Children with Various Renal Diseases

Cited by 6 publications

References 7 publications

Renal involvement in Henoch-Schönlein purpura: A multivariate analysis of prognostic factors

Renal involvement in Henoch-Schönlein purpura: A multivariate analysis of prognostic factors

Intraglomerular Deposition of Coagulation-Fibrinolysis Factors and a Platelet Membrane Antigen in Various Glomerular Diseases

Haemolytic Uraemic Syndrome and Thrombotic Thrombocytopenic Purpura: A Review

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