Localization of language cortices by functional MR imaging compared with intracarotid amobarbital hemispheric sedation.

Bahn, Mark M.; Lin, Weili; Silbergeld, Daniel L.; Miller, John W.; Kuppusamy, K.; Cook, Richard; Hammer, Gerry; Wetzel, Richard; Cross, DeWitte T.

doi:10.2214/ajr.169.2.9242780

Cited by 118 publications

(59 citation statements)

References 9 publications

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“…In one of the previous studies, Benson and colleagues reported a discrepancy in the ability of three language tasks to lateralize language in patients with brain lesions; only the verb generation task showed good language lateralizing capability and correlation with the IAP, whereas object naming and single-word reading tasks did not perform well at lateralizing language functions [29]. Bahn and colleagues reported that language lateralization with IAP and that with fMRI tasks agreed in all patients, but only the results of visual analysis were presented [13]. In contrast to the aforementioned studies, Galliard and colleagues used five different language fMRI tasks to determine language lateralization in 26 predominantly right-handed patients with epilepsy with left hemispheric seizure onset [33].…”

Section: Discussionmentioning

confidence: 96%

“…In recent years, several studies have compared fMRI and the IAP with respect to language lateralization, or evaluated the ability of fMRI to localize language functions in children and adults with epilepsy [12][13][14][15][16][17][18][19][20][21][22][23][24]. These and other authors used various language fMRI tasks including semantic decision [14,16,21,[25][26][27], verb generation/verbal fluency [13,19,20,23,[28][29][30], word generation [15,18,22,24], and sentence reading [17,31].…”

Section: Introductionmentioning

confidence: 99%

“…These and other authors used various language fMRI tasks including semantic decision [14,16,21,[25][26][27], verb generation/verbal fluency [13,19,20,23,[28][29][30], word generation [15,18,22,24], and sentence reading [17,31]. Some studies have also reported the use of more than one fMRI paradigm for language localization and lateralization [10,12,13,29,32,33], but the results of these studies have been mixed, with some tasks showing good and some poor correlation with the results of IAP. It is still not clear whether performing more than one fMRI task will contribute to the presurgical evaluation of patients with epilepsy and whether different tasks (e.g., semantic decision and word production) are of similar importance in predicting language lateralization.…”

Section: Introductionmentioning

confidence: 99%

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Comprehensive presurgical functional MRI language evaluation in adult patients with epilepsy

Szaflarski

Holland

Jacola

et al. 2008

Epilepsy & Behavior

113

137

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Functional magnetic resonance imaging (fMRI) has the potential to replace the intracarotid amobarbital procedure (IAP) in presurgical evaluation of patients with epilepsy patients. In this study, we compared fMRI verb generation (VG) and semantic decision/tone decision (SDTD) tasks and the IAP in their ability to localize language functions in patients with epilepsy undergoing presurgical evaluation. We enrolled 50 healthy controls to establish normal language activation patterns for VG and SDTD tasks at 3 or 4 T, and to design language regions of interest (ROIs) that were later applied to 38 patients with epilepsy (28 of 38 also underwent the IAP). We calculated laterality indices (LIs) for each task for each subject based on the ROIs, and we used general linear modeling to analyze the fMRI data. All healthy and epileptic subjects activated language areas with both fMRI tasks. We found significant correlations in language lateralization between the fMRI tasks (r = 0.495, P ≤ 0.001) and between VG and IAP (r = 0.652, P < 0.001) and SDTD and IAP (r = 0.735, P < 0.001). The differences in LIs between SDTD and VG tasks were small and not affected by age, gender, epilepsy status, handedness, or performance. SDTD and VG tasks combined explained approximately 58.4% in the variability of the IAP/language. In the general linear modeling, only the SDTD task significantly contributed to the determination of language lateralization in patients with epilepsy undergoing presurgical evaluation. Results indicate a moderate convergent validity between both fMRI language tasks and between IAP and fMRI tasks. The results of this study indicate that either of these fMRI tasks can be used for language lateralization in patients with epilepsy undergoing presurgical evaluation, but that the SDTD task is likely to provide more information regarding language lateralization than the VG task.

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Section: Discussionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Comprehensive presurgical functional MRI language evaluation in adult patients with epilepsy

Szaflarski

Holland

Jacola

et al. 2008

Epilepsy & Behavior

113

137

View full text Add to dashboard Cite

show abstract

“…The language tasks typically used in TLE for mapping language are semantic (Sabsevitz et al, 2003;Cousin et al, 2007) and phonological (Bahn et al, 1997;Baciu et al, 2001Baciu et al, , 2005Cousin et al, 2008) decision, word generation (Bahn et al, 1997;Hertz-Pannier, 1997;Lehericy et al, 2000), sentence reading (Rutten et al, 2000;Gaillard et al, 2002), and naming (Trebuchon-Da Fonseca et al, 2009;Ralph et al, 2012). Ideally, to identify all the substrates associated with all language operations, mapping should use an exhaustive battery of tasks, something that is currently difficult to achieve in practice, given the short time available for an examination and other specific limits on work with patients.…”

Section: Intraindividual Factors and Methodological Considerationsmentioning

confidence: 99%

“…Overall, although both the Wada test and ECS are considered gold standard methods for invasive presurgical and perisurgical mapping of language, they have limitations and drawbacks that explain why methods involving noninvasive techniques such as fMRI, have been developed (Binder, 1996;Bahn et al, 1997;Benson et al, 1999;Springer et al, 1999;Lehericy et al, 2000;Richardson, 2010;Rosazza et al, 2013). Indeed, fMRI can be used to detect atypical hemispheric language dominance of language and provides results consistent with the Wada test (Baciu et al, 2001(Baciu et al, , 2005Woermann et al, 2003;Benke et al, 2006).…”

Section: Epilepsy and Language Plasticity As Assessed By Neuroimagingmentioning

confidence: 99%

What do patients with epilepsy tell us about language dynamics? A review of fMRI studies

Baciu

Perrone‐Bertolotti

2015

Reviews in the Neurosciences

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AbstractThe objective of this review is to resume major neuroimaging findings on language organization and plasticity in patients with focal and refractory epilepsy, to discuss the effect of modulatory variables that should be considered alongside patterns of reorganization, and to propose possible models of language reorganization. The focal and refractory epilepsy provides a real opportunity to investigate various types of language reorganization in different conditions. The ‘chronic’ condition (induced by the epileptogenic zone or EZ) is associated with either recruitment of homologous regions of the opposite hemisphere or recruitment of intrahemispheric, nonlinguistic regions. In the ‘acute’ condition (neurosurgery and EZ resection), the initial interhemispheric shift (induced by the chronic EZ) could follow a reverse direction, back to the initial hemisphere. These different patterns depend on several modulatory factors and are associated with various levels of language performance. As a neuroimaging tool, functional magnetic resonance imaging enables the detailed investigation of both hemispheres simultaneously and allows for comparison with healthy controls, potentially creating a more comprehensive and more realistic picture of brain-language relations. Importantly, functional neuroimaging approaches demonstrate a good degree of concordance on a theoretical level, but also a considerable degree of individual variability, attesting to the clinical importance with these methods to establish, empirically, language localization in individual patients. Overall, the unique features of epilepsy, combined with ongoing advances in technology, promise further improvement in understanding of language substrate.

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Is the Wada Test Still Relevant? Yes

Paolicchi

2008

Arch Neurol

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Localization of language cortices by functional MR imaging compared with intracarotid amobarbital hemispheric sedation.

Cited by 118 publications

References 9 publications

Comprehensive presurgical functional MRI language evaluation in adult patients with epilepsy

Comprehensive presurgical functional MRI language evaluation in adult patients with epilepsy

What do patients with epilepsy tell us about language dynamics? A review of fMRI studies

Is the Wada Test Still Relevant? Yes

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