Localization of natriuretic peptides in the cardiac pacemaker of Atlantic salmon (Salmo salar L.)

Yousaf, Muhammad Naveed; Amin, Anil B.; Koppang, Erling Olaf; Vuolteenaho, Olli; Powell, Mark D.

doi:10.1016/j.acthis.2012.02.002

Cited by 7 publications

(1 citation statement)

References 40 publications

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“…However, in various cyprinids, salmonids and Atlantic cod, the SV lacks myocardium and consists mainly of connective tissue (Yamauchi et al, 1973;Yamauchi and Burnstock, 1968;Haverinen and Vornanen, 2007;Lukyanov et al, 1983). In these teleosts, nodal tissue is concentrated in a ring-like structure surrounding the SAV (Haverinen and Vornanen, 2007;Yamauchi, 1980;Yousaf et al, 2012). Consistent with these histological observations, electrical activity typical for primary pacemaker of the heart, with smooth transition from SDD to action potential (AP) upstroke was found in a circle region at the base of the leaflets of the SAV (Lukyanov et al, 1983(Lukyanov et al, , 1986Haverinen and Vornanen, 2007).…”

Section: Introductionmentioning

confidence: 67%

The snake heart pacemaker is localized near the sinoatrial valve

Abramochkin

Kuzmin

Matchkov

et al. 2021

Journal of Experimental Biology

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To provide the first description of the exact location of primary pacemaker of the squamate heart, we used sharp microelectrode impalements and optical mapping of isolated sinus venosus preparations from Burmese pythons. We located the dominant pacemaker site at the base of the right leaflet of the sinoatrial valve (SAV), but latent pacemakers were also identified in a circular region around the SAV. Acetylcholine (10−5M) or noradrenaline (10−6M) induced shifts of the leading pacemaker site to other points near the SAV. The ionic currents of most of the cardiomyocytes isolated enzymatically from the SAV region resembled those of typical working myocytes from the sinus venosus. However, seven cells lacked the background inward rectifier current (IK1) and had a time-dependent hyperpolarization-induced inward current identified as the “funny” current (If). Therefore, region proximal to SAV demonstrates pacemaking activity and contains cells that resemble the electrophysiological properties of mammalian pacemaker myocytes.

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Section: Introductionmentioning

confidence: 67%

The snake heart pacemaker is localized near the sinoatrial valve

Abramochkin

Kuzmin

Matchkov

et al. 2021

Journal of Experimental Biology

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Distribution and co-localization of diversified natriuretic peptides in the eel heart

et al. 2018

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Atrial and B-type natriuretic peptides (ANP and BNP) are cardiac hormones important for cardiovascular and body fluid regulation. In some teleost species, an additional member of the natriuretic peptide family, ventricular NP (VNP), has been identified. In this study, we examine tissue distribution of these three NPs in the eel heart. Quantitative real-time PCR showed that anp is almost exclusively expressed in atria, bnp equally in atria and ventricles and vnp three-fold more in ventricles than in atria. The amount of bnp transcript overall in the heart was 1/10 those of anp and vnp. There was no difference in transcript levels between freshwater and seawater-acclimated fishes. Immunohistochemistry using specific antisera and in situ hybridization using gene-specific probes showed that NP signals were detected in most atrial and ventricular myocytes with some regional differences in density. Because of high sequence similarity of the three NPs, each of the three NP antisera individually was pre-incubated with 10 M of the other two non-targeted cardiac NPs to increase the specificity. A few atrial myocytes contained all three NPs in the same cell. Immuno-electron microscopy identified many dense-core vesicles containing ANP in atria and VNP in ventricles and some vesicles contained both ANP and VNP as demonstrated using pre-absorbed antisera. Based on these data and those of previous studies, we suggest that in eels ANP is secreted from atria in a regulatory pathway and VNP from ventricles in a constitutive pathway. In addition, VNP, not BNP, is the principal ventricular hormone in eels.

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Electrical Excitability of the Fish Heart and Its Autonomic Regulation

Vornanen

2017

Fish Physiology

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Localization of natriuretic peptides in the cardiac pacemaker of Atlantic salmon (Salmo salar L.)

Cited by 7 publications

References 40 publications

The snake heart pacemaker is localized near the sinoatrial valve

The snake heart pacemaker is localized near the sinoatrial valve

Distribution and co-localization of diversified natriuretic peptides in the eel heart

Electrical Excitability of the Fish Heart and Its Autonomic Regulation

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