Localization of Radioactivity of Colloidal Gold198

ICRP Publication 151: Occupational Intakes of Radionuclides: Part 5

“…(b) Elemental gold (610) Berg (1951) investigated the distribution of 198 Au in dogs 3 d after injection of 198 Au-labelled colloidal gold particles into the pleural cavity. Activity found outside the lungs was predominantly in the liver and spleen, and therefore may have transferred mainly in particulate form rather than in solution.…”

“…Activity found outside the lungs was predominantly in the liver and spleen, and therefore may have transferred mainly in particulate form rather than in solution. (611) Bryant et al. (1953) and Berg et al. (1954) measured the uptake of 198 Au-labelled colloidal gold (3–4-nm diameter) into the hilar lymph nodes of dogs for up to ∼30 d after instillation into the bronchial lumen, or injection into the submucosa of a bronchus.…”

“…(611) Bryant et al. (1953) and Berg et al. (1954) measured the uptake of 198 Au-labelled colloidal gold (3–4-nm diameter) into the hilar lymph nodes of dogs for up to ∼30 d after instillation into the bronchial lumen, or injection into the submucosa of a bronchus.…”

ANNEX B: Deposition, characterisation, and sampling of radioactive aerosols

“…This is consistent with observations that the intercellular clefts in pulmonary blood capillaries do not exceed 4 nm (Lauweryns and Baert, 1977). Particles with diameters between a few nanometres and a few microns that were to enter the bloodstream would be expected to deposit predominantly in liver and spleen and be retained there (Berg, 1951;Kreyling et al, 1986). The absence of marked accumulation of activity in these organs following inhalation has been interpreted by a number of authors as evidence for the low rate of particle penetration of lymph nodes (Publication 66, Section E.7.4), but it similarly indicates a lack of significant direct movement of particles from the respiratory tract itself to the bloodstream.…”

Some Less Common Therapeutic Uses of Radioisotopes

“…In an attempt to produce localization of radioactive colloids in organs other than the liver and spleen, Berg (1951) has used arterial injection into the vessel supplying the organ he wishes to study. He has found that under normal circumstances, the distribution, as compared with that after intravenous injection, is not significantly changed, but when he clamps the efferent vein as well as the artery for one minute, concentrations of up to 1,000 times normal can be obtained.…”