Localization of T-cell subsets in cutaneous lichen planus: An insight into pathogenetic mechanism

Rana, Safia; Gupta, Ruchika; Singh, Sompal; Mohanty, Sandip; Gupta, Kusum; Kudesia, Madhur

doi:10.4103/0378-6323.72452

Cited by 8 publications

(4 citation statements)

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“…This is supported by De Vries et al, who found dramatic increases in plasmacytoid dendritic cells and upregulation of IFNs in cutaneous and oral lesions of LP [7]. Our finding of predominantly CD8+ T-cells in the inflammatory infiltrate ( Figure 2C) was reinforced by Rana et al, who noted a significant prevalence of CD8+ T-cells in the inflammatory dermo-epidermal infiltrate of 20 cases with cutaneous LP [8].…”

Section: Discussionsupporting

confidence: 87%

Cutaneous Lichen Planus Induced by Secukinumab

Doolan¹,

Anderton²,

Christie³

et al. 2017

J Clin Exp Dermatol Res

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Lichen planus (LP) is a chronic mucocutaneous disease, characterised by an inflammatory immune response with sub-epithelial infiltration of T lymphocytes causing basal epithelial cell damage. Secukinumab is a monoclonal antibody that blocks IL-17A; which is the primary cytokine of Th17 cells involved in the aetiology of inflammatory skin diseases such as psoriasis. Secukinumab has been linked to induction of oral LP, but never directly to cutaneous LP. We report the first case of drug-induced cutaneous LP in the setting of secukinumab for treatment of chronic plaque psoriasis. A 56-year-old man with chronic plaque psoriasis presented with a 2-month history of violaceous and pruritic, thickened plaques on his bilateral lower limbs and buttocks in the setting of secukinumab use for psoriasis. Histological analysis showed a band-like lymphocyte inflammatory infiltrate just beneath the epithelium and was consistent with cutaneous LP. He was treated with topical betamethasone dipropionate cream with moderate effect. Initial laboratory tests including hepatitis and inflammatory screens were within normal limits. We hypothesise that this causal association may be due to a microbial trigger, activating a T-cell mediated immunologic response in CD8+ T-cells and dendritic cells, causing activation of type I interferons and an inflammatory skin response consistent with LP. Clinicians should monitor patients for mucosal and cutaneous LP when using secukinumab or other biologic modulators of IL-17 for extended periods with psoriasis.

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Section: Discussionsupporting

confidence: 87%

Cutaneous Lichen Planus Induced by Secukinumab

Doolan¹,

Anderton²,

Christie³

et al. 2017

J Clin Exp Dermatol Res

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“…The accumulation of T lymphocytes in tissue is considered a cell-mediated immune reaction to bodily injury [ 38 ], particularly in patients with immune dysfunction [ 39 ]. The accumulation of perivascular CD4+ T lymphocytes occurs in patients with cutaneous lichen planus [ 40 ] and in the muscle tissue of patients with dermatomyositis [ 41 ]. Some studies found that T cells might be involved in the pathogenesis of interstitial lung disease.…”

Section: Resultsmentioning

confidence: 99%

Prognosis of nonspecific interstitial pneumonia correlates with perivascular CD4+ T lymphocyte infiltration of the lung

et al. 2015

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BackgroundNonspecific interstitial pneumonia (NSIP) is characterized by interstitial infiltration of T lymphocytes, and subpopulations of these cells may be associated with the progression of fibrosis. However, few studies evaluate the correlation of prognosis with this characteristic. Therefore, we performed morphological and quantitative analyses of T lymphocytes in patients with NSIP and evaluated the relationship between T lymphocytes and prognosis.MethodsImmunohistochemistry was used to detect the presence of CD4+ and CD8+ T lymphocytes in 55 biopsies of patients with NSIP to determine the numbers of these T cell subpopulations in lymphoid follicles as well as in perivascular, interstitial, and peribronchial anatomical compartments. The relationship between CD4+ and CD8+ T lymphocyte populations and prognosis was analyzed.ResultsThe mean age of 55 patients was 48.9 ± 10.5 years, and 36 (65 %) of patients were women. All patients were followed for a mean duration of 46 ± 25 months. Thirteen (23.6 %) patients died during follow-up. Perivascular CD4+ lymphocyte infiltration (HR, 0.939; 95 % CI, 0.883–0.999; p = 0.048) was an independent risk factor for survival. Perivascular infiltrates of CD4+ T lymphocytes correlated with survival time (r = 0.270, p = 0.046). Patients with improved forced vital capacity survived longer and had higher numbers of CD4+ T lymphocytes that infiltrated perivascular tissue. The densities of CD4+ and CD8+ T lymphocytes infiltrating other tissues were not significantly associated with survival time.ConclusionsPerivascular infiltration of CD4+ T lymphocytes in patients with NSIP correlated with prognosis. The underlying mechanisms are unknown and require further studies.Electronic supplementary materialThe online version of this article (doi:10.1186/s12890-015-0122-z) contains supplementary material, which is available to authorized users.

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“…Rana et al . [ 28 ] detected that CD4+ T-cells predict potential Th1 cytokine-mediated support for cytotoxic CD8+ cells. If CD8+ T-cells killed keratinocytes, the basement membrane would break down.…”

Section: Discussionmentioning

confidence: 99%

Immunohistochemical expression of T-cell subsets (CD4 and CD8) in oral lichen planus

Rassol¹,

Zaidan²

2023

Pan Afr Med J

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Introduction oral lichen planus (OLP) is a common oral mucosal disease with various clinical manifestations. The most predominant types are reticular and erosive. Despite extensive research on the causes of OLP, the exact etiology remains unclear. However, it is believed that a T-cell-mediated response, which triggers the apoptosis of oral epithelial cells, may contribute to the development of this disorder. This study aims to investigate the different types of T-cells (specifically CD4 and CD8) present in OLP tissue samples. By using immunohistochemistry, the expressions of cluster of differentiation 4 (CD4) and cluster of differentiation 8 (CD8) will be evaluated in biopsy samples taken from OLP patients who exhibit various clinical presentations. Methods this study was a retrospective analysis study. Oral lichen planus was established histologically in forty paraffin-embedded tissue samples. Blocks of OLP were diagnosed and characterized as reticular or erosive. Immunohistochemical staining was conducted using a monoclonal antibody for (CD4) and a polyclonal antibody for CD8. Semi-quantitative techniques were used to analyze the patterns of positively stained cells. Results: forty biopsies of OLP cases were obtained from 24 females and 16 males. The mean age was (49.15±11.39) years. Using an immunohistochemical method, the proportion of CD4 expression: CD8 expression among the epithelial-connective tissue interface was shown to be 24 (60%) cases with a predominance of CD8, 9 (22.5%) cases with no difference, and only 7 (17.5%) cases with a predominance of CD4. The proportion of CD4: CD8 among perivascular parts was shown to be 8 (20%) cases with a predominance of CD8, 20 (50%) cases with no difference, while only 12 (30%) cases had a predominance of CD4. The CD4 perivascular expression was significantly stronger in (71.4%) of erosive OLP than in reticular cases. Conclusion T-cell subsets (CD4 and CD8) were found in the OLP infiltrates. The correlation may have contributed to the pathogenesis of OLP.

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Localization of T-cell subsets in cutaneous lichen planus: An insight into pathogenetic mechanism

Cited by 8 publications

References 1 publication

Cutaneous Lichen Planus Induced by Secukinumab

Cutaneous Lichen Planus Induced by Secukinumab

Prognosis of nonspecific interstitial pneumonia correlates with perivascular CD4+ T lymphocyte infiltration of the lung

Immunohistochemical expression of T-cell subsets (CD4 and CD8) in oral lichen planus

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