Localization of the oncogene c‐<i>erb</i>A2 to human chromosome 3

Rider, Susan H.; Gorman, Patricia; Shipley, Janet; Moore, Gudrun E.; Vennström, Björn; Solomon, Ellen; Sheer, Denise

doi:10.1111/j.1469-1809.1987.tb01057.x

Cited by 18 publications

(10 citation statements)

References 28 publications

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“…The ERBA1 oncogene is joined by ERBA2 and an ERBA2-like sequence at 17q21 and 17q25 respectively (G osden et al 1986). This assignment is inconsistent with that reported by Rider et al (1987) who assigned ERBA2 to chromosome 3. A homeobox-containing gene, C l, isolated by homology to Drosophila sequences from a human transformed fibroblast cDNA library, was assigned to 17q21-q22 by Cannizzaro et al (HGM9).…”

contrasting

confidence: 56%

Report of the committee for chromosomes 17, 18, and 19

Shaw¹,

Eiberg²

1987

Cytogenet Genome Res

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contrasting

confidence: 56%

Report of the committee for chromosomes 17, 18, and 19

Shaw¹,

Eiberg²

1987

Cytogenet Genome Res

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“…Allelic loss was not correlated with any particular histology, except that patient 17, with malignant carcinoid, showed allelic loss at 3p, whereas patients 29 and 34, with typical carcinoid, although informative a t severa P 3p loci, did not show all& (1984). ERBAZ is locataed to 3p21-pter by Rider et al (1987) and by us t o 3p24 (Albertson et al, 1989). THR (ERE-AD) is located to 3p2 1-3p25 by Dobrovic et al ( I 988) and by us to 3p24 (Albertson et al, 1989).…”

Section: Loss Of Heterozygosity Of Alleles On Chromosome 3 In Patientmentioning

confidence: 90%

Frequency and extent of allelic loss in the short arm of chromosome 3 in nonsmall‐cell lung cancer

Rabbitts

Douglas

Daly

et al. 1989

Genes Chromosomes & Cancer

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DNA was prepared from tumour and normal tissue from 48 patients representing all common histological types of nonsmall-cell lung cancer. Using eight DNA probes, which detect nine restriction enzyme fragment length polymorphisms (RFLP) on chromosome 3, we established that among the 44 informative patients 32 had lost alleles on the short arm of one of their copies of chromosome 3. Of these 32, at least 13 had also lost alleles on the long arm of chromosome 3, suggesting that the whole chromosome might be lost. For one patient, cytogenetic analysis indicated that the mechanism of allelic loss was reciprocal translocation followed by chromosomal loss of one of the reciprocal products. Two patients with allelic loss distal to the D3S3 locus (which maps to 3p13-14) retained heterozygosity at that locus. These results indicate that loss of alleles on the short arm of chromosome 3 is a common event in lung tumours of the nonsmall-cell type, that this loss occurs by a variety of chromosomal mechanisms, and that the minimally deleted region is 3p13-14----3pter.

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“…The gene for thyroid hormone receptor (THR) also located on the short arm of chromosome 3 has been confirmed (Dobrovic et al 1988;Rider et al 1987;Drabkin et al 1987). THR, which shows homology with ERBA, has been regionally mapped to 3p21.33-p22 (Drabkin et al 1987).…”

Section: Confirmation Of Assignments To Chromosomementioning

confidence: 96%