Localized 3D analysis of cartilage composition and morphology in small animal models of joint degeneration

Thote, Tanushree; Lin, Angela; Raji, Yazdan; Moran, Shamus; Stevens, Hazel Y.; Hart, Michelle; Kamath, Rajesh V.; Guldberg, Robert E.; Willett, Nick J.

doi:10.1016/j.joca.2013.05.018

Cited by 53 publications

(75 citation statements)

References 43 publications

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“…Articular cartilage structure and composition were quantitatively evaluated in the tibial plateau as described in our previous study [13]. Scanco evaluation software was used to assess three-dimensional morphological parameters and local attenuation.…”

Section: Methodsmentioning

confidence: 99%

“…Previous studies have validated this methodology to quantify compositional and structural changes, such as cartilage proteoglycan content, thickness and volume [9,11,12]. Our previous study has characterized the rat MMT model using EPIC-μCT and demonstrated changes in the articular cartilage [13]. These studies have further demonstrated the sensitivity to detect chemically- or mechanically-induced degenerative changes.…”

Section: Introductionmentioning

confidence: 96%

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Intra-articular injection of micronized dehydrated human amnion/chorion membrane attenuates osteoarthritis development

et al. 2014

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Introduction: Micronized dehydrated human amnion/chorion membrane (μ-dHACM) is derived from donated human placentae and has anti-inflammatory, low immunogenic and anti-fibrotic properties. The objective of this study was to quantitatively assess the efficacy of μ-dHACM as a disease modifying intervention in a rat model of osteoarthritis (OA). It was hypothesized that intra-articular injection of μ-dHACM would attenuate OA progression.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 96%

Intra-articular injection of micronized dehydrated human amnion/chorion membrane attenuates osteoarthritis development

et al. 2014

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“…Resulting cartilage X-ray attenuation in these scans is inversely related to sGAG content and thereby represent cartilage quality. This technique is suited for quantitative analysis of cartilage degradation for preclinical evaluation of OA [36].…”

Section: Cartilage Evaluation With Contrast Enhanced μCt and Histologymentioning

confidence: 99%

Inhibited osteoclastic bone resorption through alendronate treatment in rats reduces severe osteoarthritis progression

Siebelt

Waarsing

Groen

et al. 2014

Bone

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“…Preferential exclusion results in an increase in tissue attenuation inversely proportional to sGAG concentration. It has been successfully applied to the imaging of articular cartilage in mouse and rat femora (81–87), cartilage in murine xiphoid (88), caprine osteochondral defects of the talus (89), and more recently, in rabbit intervertebral discs (90). …”

Section: Resultsmentioning

confidence: 99%

The use of nano-computed tomography to enhance musculoskeletal research

Khoury¹,

Bigelow

Smith

et al. 2015

Connective Tissue Research

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Advances in computed tomography (CT) imaging are opening new avenues toward more precise characterization and quantification of connective tissue microarchitecture. In the last two decades, micro-computed tomography (microCT) has significantly augmented destructive methods for the 3D micro-analysis of tissue structure, primarily in the bone research field. Recently, microCT has been employed in combination with contrast agents to generate contrast-enhanced images of soft tissues that are otherwise difficult to visualize due to their native radiodensity. More recent advances in CT technology have enabled ultra-high resolution imaging by utilizing a more powerful nano-focused X-ray source, such as that found in nano-computed tomography (nanoCT) systems. NanoCT imaging has facilitated the expansion of musculoskeletal research by reducing acquisition time and significantly expanding the range of samples that can be imaged in terms of size, age and tissue-type (bone, muscle, tendon, cartilage, vessels and adipose tissue). We present the application and early results of nanoCT imaging in various tissue types and how this ultra-high resolution imaging modality is capable of characterizing microstructures at levels of details previously not possible. Contrast-enhanced imaging techniques to enable soft-tissue visualization and characterization are also outlined.

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Localized 3D analysis of cartilage composition and morphology in small animal models of joint degeneration

Cited by 53 publications

References 43 publications

Intra-articular injection of micronized dehydrated human amnion/chorion membrane attenuates osteoarthritis development

Intra-articular injection of micronized dehydrated human amnion/chorion membrane attenuates osteoarthritis development

Inhibited osteoclastic bone resorption through alendronate treatment in rats reduces severe osteoarthritis progression

The use of nano-computed tomography to enhance musculoskeletal research

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