Localized Amyloid Deposition in Trigger Finger

Cordiner-Lawrie, S.; Diaz, J.; Burge, P. D.; Athanasou, Nicholas A.

doi:10.1054/jhsb.2001.0571

Cited by 20 publications

(10 citation statements)

References 12 publications

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“…Amyloid deposits have been identified in connective tissue beneath the synovial lining of the flexor tendon sheath in patients with idiopathic trigger finger. 25 In the general population, there seems to be a link between CTS and trigger finger, with concomitant occurrence in 16% to 61% of patients. 26 An association between CTS and trigger finger may be underappreciated in patients with amyloidosis.…”

Section: Clinical Presentation and Pathophysiology Of Amyloid Deposition In Musculoskeletal Connective Tissue (Fig 1)mentioning

confidence: 98%

“…There is precedent in the literature (Table 1) 2,16,17,25,[33][34][35][36][37][38][39] for identifying amyloidosis using the approach suggested in Figure 2. Earlier studies (from the 1950s through the 1980s) simply identified the presence of amyloid using Congo red staining, and later studies (beginning around the late 1980s) typed the protein source of amyloid using immunohistochemistry.…”

Section: Diagnosismentioning

confidence: 99%

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Carpal Tunnel Syndrome: A Potential Early, Red-Flag Sign of Amyloidosis

Donnelly

Hanna

Sperry

et al. 2019

The Journal of Hand Surgery

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Carpal tunnel syndrome (CTS) can be caused by the deposition and accumulation of misfolded proteins called amyloid and is often an early manifestation of systemic amyloidosis. In patients undergoing surgery for idiopathic CTS, a recent study identified amyloidosis by tenosynovial biopsy in 10.2% of men older than 50 years and women older than 60 years; all positive patients had bilateral symptoms. These findings have led to a renewed interest in CME INFORMATION AND DISCLOSURESThe Journal of Hand Surgery will contain at least 2 clinically relevant articles selected by the editor to be offered for CME in each issue. For CME credit, the participant must read the articles in print or online and correctly answer all related questions through an online examination. The questions on the test are designed to make the reader think and will occasionally require the reader to go back and scrutinize the article for details.The JHS CME Activity fee of $15.00 includes the exam questions/answers only and does not include access to the JHS articles referenced.Statement of Need: This CME activity was developed by the JHS editors as a convenient education tool to help increase or affirm reader's knowledge. The overall goal of the activity is for participants to evaluate the appropriateness of clinical data and apply it to their practice and the provision of patient care. Accreditation:The American Society for Surgery of the Hand (ASSH) is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.AMA PRA Credit Designation: The ASSH designates this Journal-Based CME activity for a maximum of 1.00 AMA PRA Category 1 Creditsä. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

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Section: Clinical Presentation and Pathophysiology Of Amyloid Deposition In Musculoskeletal Connective Tissue (Fig 1)mentioning

confidence: 98%

Section: Diagnosismentioning

confidence: 99%

Carpal Tunnel Syndrome: A Potential Early, Red-Flag Sign of Amyloidosis

Donnelly

Hanna

Sperry

et al. 2019

The Journal of Hand Surgery

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“…Autonomic failure, including impotence, diarrhea, or constipation, orthostatic hypotension, bladder dysfunction and sweating abnormalities occurred in 67% of the patients. Otherwise, cardiac abnormalities occurred in 67%, dysphagia in 50%, dysphonia in 42%, and (9). However, to our knowledge, no trigger finger associated with specific transthyretin mutations has been reported.…”

Section: Discussionmentioning

confidence: 78%

Trigger Finger as an Initial Manifestation of Familial Amyloid Polyneuropathy in a Patient with Ile107Val TTR

et al. 2007

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“…It is particularly significant that fibrocartilage was present in the midsubstance of the CAL in 50% of the younger individuals, although there was no clear tendency for it to be a particular feature of individuals who were either younger or older than 20 years of age. Such fibrocartilage in a tendon or ligament is sometimes regarded as a sign of degeneration and is referred to as a form of “mucoid degeneration” by pathologists (Leadbetter et al, 1992; Mosier et al, 1999; Cordiner‐Lawrie et al, 2001). Although fibrocartilage can indeed be of pathological significance (e.g.…”

Section: Discussionmentioning

confidence: 99%

The structure of the coracoacromial ligament: fibrocartilage differentiation does not necessarily mean pathology

Milz

Jakob

Büttner

et al. 2007

Scandinavian Med Sci Sports

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The coracoacromial ligament forms part of the coracoacromial arch and is implicated in impingement syndrome and acromial spur formation. Here, we describe its structure and the composition of its extracellular matrix. Ligaments were obtained from 15 cadavers, nine from older people (average age 74.7 years) and six from younger individuals (average age 24.2 years). Cryosections of methanol-fixed tissue were cut and sections were immunolabelled with monoclonal antibodies against collagens, glycosaminoglycans, proteoglycans, matrix proteins and neurofilament proteins. Both ligament entheses were highly fibrocartilaginous and immunolabelled strongly for type II collagen, aggrecan and link protein. The area of labelling was more extensive in older people. However, fibrocartilage also characterized the ligament midsubstance, particularly with increased age. Signs of fibrocartilage degeneration were more common in older people. Ligament fat (containing blood vessels and nerve fibers) was conspicuous in both age groups, especially between fiber bundles at the entheses. We conclude that fibrocartilage is a normal feature but becomes more pronounced with age. It is not necessarily pathological, for it simply indicates that the ligament is subject to compression and/or shear. Nevertheless, the prominence of fibrocartilage at the acromial enthesis may relate to the frequency with which enthesophytes develop.

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Localized Amyloid Deposition in Trigger Finger

Cited by 20 publications

References 12 publications

Carpal Tunnel Syndrome: A Potential Early, Red-Flag Sign of Amyloidosis

Carpal Tunnel Syndrome: A Potential Early, Red-Flag Sign of Amyloidosis

Trigger Finger as an Initial Manifestation of Familial Amyloid Polyneuropathy in a Patient with Ile107Val TTR

The structure of the coracoacromial ligament: fibrocartilage differentiation does not necessarily mean pathology

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