Localized amyloidosis in usual-type vulvar intraepithelial neoplasia: High-risk HPV association and potential clinical significance. A series of 45 cases

Introduction. Being considered as one of the most difficult to cure, vulvar malignant neoplasms belong to rare oncopathologies of the female reproductive system. It is established that vulvar squamous cell cancer develops via two pathways. In the first scenario, the tumor may develop during vulvar dystrophic diseases such as scleroatrophic lichen and differentiated intraepithelial neoplasia. Another opportunity is directly related to HPV infection. Highly oncogenic HPV types are known to be associated with cervical carcinogenesis and are involved in developing vulvar, vaginal, and anal intraepithelial neoplasia, which are considered precursors to carcinomas. In recent decades, a rise in incidence of vulvar cancer developed after preceding degenerative processes was noted. A relationship between human papillomavirus and cervical cancer has long been known and confirmed, so an issue regarding a potential relation between the etiology of vulvar cancer and of HPV remains relevant. The aim of the paper is to systematize and analyze the study data on vulvar carcinogenesis related to HPV infection. Materials and Methods. A literature search was performed using PubMed, Web of Science and Google Scholar databases. A literature review was conducted by analyzing studies published between 1993 and 2024. The review included papers in which HPV was found in more than one case of vulvar tumor and if HPV DNA was detected by using polymerase chain reaction. Initially 249 articles were selected, 25 papers were included in the qualitative analysis, from which 6 case-control studies that fully met the specified inclusion criteria were further analyzed. Overall HPV prevalence was calculated as the percentage of all HPV tested cases. Results. A high prevalence of papillomavirus infection in vulvar tumors was shown (31%), with HPV type 16 occurring in the vast majority of cases. The prevalence of HPV in vulvar tumors in case-control studies was 30% (OR = 10.46). Conclusions. The results of the current systematic review confirmed that HPV infection is a key risk factor for developing vulvar malignancies. We demonstrated a high prevalence of HPV infection in vulvar tumors. In addition, a high incidence of highly oncogenic HPV types in tumor tissue was shown.

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Localized amyloidosis in usual-type vulvar intraepithelial neoplasia: High-risk HPV association and potential clinical significance. A series of 45 cases

Cited by 2 publications

References 15 publications

Progress of Diagnosis and Treatment of Vulvar Cancer

Progress of Diagnosis and Treatment of Vulvar Cancer

Human Papillomavirus in Vulvar Cancer: A Systematic Review

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