Localized amyloidosis of the urinary bladder, clinically masquerading as bladder cancer

Desouza, Maria Alina; Rekhi, Bharat; Thyavihally, Y.; Tongaonkar, Hemant; Desai, Sangeeta

doi:10.4103/0377-4929.42547

Cited by 5 publications

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Depending on the degree of disease involvement, patients may present with painless hematuria, irritative urinary symptoms, and obstructive symptoms. 6 Ultrasound, CT scan, and MRI are often used as initial methods to evaluate patients with urinary bladder amyloidosis. MRI T2‐weighted imaging can distinguish it from urothelial carcinoma by characteristic hypointense lesion with noticeable mass effect.…”

Section: Discussionmentioning

confidence: 99%

Primary bladder amyloidosis mimicking bladder cancer complicated by bladder rupture: A case report

Sibira

Albakar

Younes

et al. 2021

Clinical Case Reports

View full text Add to dashboard Cite

Amyloidosis refers to a non-neoplastic heterogeneous group of disorders related to the extracellular deposition of insoluble fibrils in different organs. 1 Amyloidosis can be primary, secondary, and hereditary. Primary amyloidosis (AL) is usually related to plasma cell abnormalities. On the contrary, secondary amyloidosis (AA) occurs due to longstanding infections, inflammation, or neoplastic insults. Eventually, hereditary amyloidosis (ATTR) is related to autosomal-dominant inherited mutations in transthyretin protein gene. 1 Amyloidosis can be systemic, which is usually progressive and fatal or localized. Localized amyloidosis of the urinary bladder is rare, with the most extensive series reported 31 cases. 2 The clinical importance of bladder amyloidosis is that it mimics bladder cancer. Although amyloidosis is a benign condition, it was associated with urothelial carcinoma in 48% of 21 cases reported. 3 Here, we present a case of localized bladder amyloidosis with a review of the literature. Interestingly, this is the first case

show abstract

Section: Discussionmentioning

confidence: 99%

Primary bladder amyloidosis mimicking bladder cancer complicated by bladder rupture: A case report

Sibira

Albakar

Younes

et al. 2021

Clinical Case Reports

View full text Add to dashboard Cite

show abstract

Amyloidosis of the Unilateral Renal Pelvis, Ureter and Urinary Bladder: a Case Report

Pan

2011

Chinese Medical Sciences Journal

View full text Add to dashboard Cite

How to manage primary amyloidosis

Gertz

2011

Leukemia

View full text Add to dashboard Cite

Immunoglobulin light chain amyloidosis is a protein deposition disorder where the precursor protein represents a monoclonal immunoglobulin light or heavy chain. Deposition in viscera results in restrictive cardiomyopathy, nephrotic range proteinuria, demyelinating peripheral neuropathy, hepatomegaly and malabsorption syndrome. Diagnosis requires biopsy with Congo red staining. Invasive biopsies are not required generally. It is essential that after a histologic diagnosis is obtained, the tissue is validated to have an immunoglobulin light chain composition so patients are spared unnecessary chemotherapy. The disease prognosis and patient monitoring are linked to serialized measurement of cardiac biomarkers and immunoglobulin-free light chains. Most patients require cytotoxic chemotherapy. For some patients, this therapy involves stem cell collection and myeloablative chemotherapy; for others, chemotherapy includes an alkylator and a corticosteroid; and for some, it involves addition of a novel agent in the form of an immunomodulatory drug or a proteasome inhibitor. Delays in diagnosis continue to be an obstacle to initiating effective therapy. Early mortality rates remain high. Effective chemotherapy can result in reversal of organ dysfunction and recovery. Reductions in light chain production translate to improved survival.

show abstract

Localized amyloidosis of the urinary bladder, clinically masquerading as bladder cancer

Cited by 5 publications

References 0 publications

Primary bladder amyloidosis mimicking bladder cancer complicated by bladder rupture: A case report

Primary bladder amyloidosis mimicking bladder cancer complicated by bladder rupture: A case report

Amyloidosis of the Unilateral Renal Pelvis, Ureter and Urinary Bladder: a Case Report

How to manage primary amyloidosis

Contact Info

Product

Resources

About