Localized Bullous Eruptions Caused by Extravasation of Commonly Used Intravenous Infusion Fluids

Robijns, B.J.L.; Wit, W.M. de; Bosma, N.J.; Vloten, W. A. van

doi:10.1159/000247735

Cited by 12 publications

(4 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Extravasation of hypertonic solutions (eg, osmolarity Ͼ 350 mOsm/L) causes a fluid shift from inside cells to the interstitial space, 2 which disrupts cell function. 18,24 The shift from subcutaneous cells to interstitial tissues leads to swelling and increased local pressure, which can cause ALCS and other injuries. 18 While hyperosmolar solutions can shrink cells and collapse the internal structures, hypoosmolar solutions can swell cells and lead to cell rupture.…”

Section: Ph and Osmolaritymentioning

confidence: 99%

Infiltration and Extravasation

Doellman

Hadaway²,

Bowe-Geddes³

et al. 2009

Journal of Infusion Nursing

181

View full text Add to dashboard Cite

Infiltration and extravasation are risks of intravenous administration therapy involving unintended leakage of solution into the surrounding tissue. Consequences range from local irritation to amputation. While immediate action using appropriate measures (ie, dilution, extraction, antidotes, and supportive treatments) can decrease the need for surgical intervention, many injuries may be prevented by following established policy and procedures. However, timely surgical intervention, when necessary, can prevent more serious adverse outcomes. Clinicians should be prepared to act promptly when an event occurs. Thorough incident documentation helps determine whether infusion care meets the standard of practice and is a keystone to medicolegal defense.

show abstract

Section: Ph and Osmolaritymentioning

confidence: 99%

Infiltration and Extravasation

Doellman

Hadaway²,

Bowe-Geddes³

et al. 2009

Journal of Infusion Nursing

181

View full text Add to dashboard Cite

show abstract

“…We believe that in addition to the trauma caused by the intravenous cannula, extravasation of the infusion fluids (normal saline and dextrose) may have occurred, precipitating bullous eruptions and ulceration in our patient. Intravenous dextrose solutions, especially concentrations above 10%, may cause tissue necrosis [10,11]. Tissue damage with bullous eruptions following extravasation of normal saline has also been reported, and clinicians need to be aware of this potential complication [12].…”

Section: Discussionmentioning

confidence: 99%

Recalcitrant Foot Ulceration in a Patient With Type 1 Diabetes Mellitus

Vazeille

Hawker

Chandrasekar

et al. 2020

Cureus

View full text Add to dashboard Cite

We describe the case of a middle-aged woman with type 1 diabetes mellitus who presented to the emergency department with diabetic ketoacidosis. An intravenous cannula was inserted into the veins of the dorsum of the right foot due to difficulty in obtaining intravenous access in the upper limb for managing diabetic ketoacidosis. Our patient developed edema and bullae on the dorsum of the right foot and received intravenous antibiotics for bullous cellulitis. Our patient developed ulceration on the dorsum of the right foot and over the next few months was admitted to hospital on several occasions with infected foot ulceration, which required several courses of intravenous antibiotics, larval therapy and surgical debridement of the necrotic eschar and slough. With regular review in the multidisciplinary diabetic foot clinic, the foot ulceration finally healed in eight months. This case highlights the importance of avoiding trauma in any form to the feet of people with diabetes even if aseptic techniques are taken.

show abstract

“…In addition, extravasation of solutions which arc hypertonic, acidic or alkaline can lead to tissue necrosis by disruption of cellu lar membrane transport systems (osmotic damage) or precipitation of proteins; this group includes nafcillin. sodium bicarbonate, and potassium and calcium salts [ 16,17]. In the case of pentamidine, there may be direct cyto toxicity, or the drug may function as a hapten by binding to nucleic acids [18], Unfortunately, treatment of chemical cellulitis is pri marily supportive.…”

Section: Discussionmentioning

confidence: 99%

“…The patient described in this report did not require grafting, but she did have a residual loss of cuta neous sensation. Robijns et al [17] have made several recommendations for the prevention of extravasation of intravenous fluids including selection of the right location for the infusion, the use of flexible catheters and frequent observation of the site of infusion.…”

Section: Discussionmentioning

confidence: 99%

Cutaneous Ulceration: An Unusual Complication of Intravenous Pentamidine Therapy

1991

Dermatology

View full text Add to dashboard Cite

Pentamidine is one of two agents currently used to treat infections with Pneumocystis carinii. The intramuscular route of administration is associated with cutaneous side effects such as dermal necrosis, sterile abscesses and ulcer formation at the injection site, while urticaria may develop near the site of intravenous drug infusion. This is a report of a renal transplant patient with Pneumocystis pneumonia who developed chemical cellulitis and ulceration following the extravasation of intravenous pentamidine into the soft tissues of the left hand and forearm. The area healed slowly over 7 weeks but there was a residual loss of cutaneous sensation. In a review of the literature no report of a similar case was found.

show abstract

Localized Bullous Eruptions Caused by Extravasation of Commonly Used Intravenous Infusion Fluids

Cited by 12 publications

References 5 publications

Infiltration and Extravasation

Infiltration and Extravasation

Recalcitrant Foot Ulceration in a Patient With Type 1 Diabetes Mellitus

Cutaneous Ulceration: An Unusual Complication of Intravenous Pentamidine Therapy

Contact Info

Product

Resources

About