Localized contractions in the normal human bladder and in urinary urgency

Drake, Marcus; Harvey, Ian J.; Gillespie, James; Duyl, W. A. van

doi:10.1111/j.1464-410x.2005.05455.x

Cited by 130 publications

(122 citation statements)

References 13 publications

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“…DO) are more prevalent in bladder outlet obstruction patients compared with healthy volunteers, and their prevalence rise continuously with increasing grade of obstruction (Robertson, 1999;Nordling, 2002;Oelke et al, 2008). Localized NVCs were also more prevalent and sustained, and have a higher frequency in patients with urinary urgency compared to asymptomatic controls (Drake et al, 2005). Present data indicate that voiding volume in conscious obstructed guinea pigs was inversely correlated with frequency of spontaneous contractions of their isolated bladders.…”

Section: Bladder Contractions In Vitro and Non-voiding Contractions (supporting

confidence: 54%

Conscious voiding during bladder obstruction in guinea pigs correlates with contractile activity of isolated bladders

Nicholas

Keightley

Brookes

et al. 2015

Autonomic Neuroscience

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Purpose: There are many hypotheses accounting for detrusor overactivity, however the exact mechanisms are still incompletely understood. We used a model of bladder outlet obstruction in male guinea pigs as a way to produce detrusor overactivity. The objective was to determine whether changes in voiding of obstructed guinea pigs correlates with specific changes in contractile activity of their isolated bladders in vitro. Material and methods: Conscious voiding activity of sham-operated and obstructed animals was measured in metabolic cages. Contractile activity (spontaneous or evoked by distension, electrical field stimulation or cholinergic agonists) was recorded via a pressure transducer in the isolated bladders in vitro. Results: The frequency of conscious voiding increased (while voiding volume decreased) in the obstructed group, compared with the sham-operated group, 4 weeks after surgical intervention. In comparison to the sham-operated animals, the bladders from the obstructed guinea pigs were enlarged and inflamed, their frequency of spontaneous contractions was higher, while the amplitudes of electrical field stimulation (EFS)-induced contractions and bladder compliance were lower. Changes in conscious voiding during obstruction were significantly associated with alterations in structural parameters (bladder weight, thickness and histological damage score) and functional contractile parameters (frequency of spontaneous contractions, amplitude of EFS-induced contractions and bladder compliance) of their isolated bladders. Conclusions: Our findings revealed significant association between conscious voiding and structural and contractile activity changes of the isolated bladders in obstruction. The data suggest that change in contractile activity of the bladder itself is a major contributor to obstruction-induced bladder overactivity.

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Section: Bladder Contractions In Vitro and Non-voiding Contractions (supporting

confidence: 54%

Conscious voiding during bladder obstruction in guinea pigs correlates with contractile activity of isolated bladders

Nicholas

Keightley

Brookes

et al. 2015

Autonomic Neuroscience

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“…In ex vivo intact bladder models, motion and intravesical pressure analysis shows tetrodotoxin and atropine-resistant low amplitude (≈ 1 cmH2O) phasic contractile activity occurring at a frequency of 0.01-0.1 Hz [14]. Similar micromotional activity has been detected during human bladder filling, and is more marked in those with increased sensation [15]. Isolated bladder strips in animal models including mouse show autonomous low amplitude repetitive contractions occurring at similar low frequencies (0.02-0.03 Hz) [16,17], thus suggesting whole bladder contractile activity is intrinsic to the bladder wall.…”

Section: Introductionmentioning

confidence: 51%

Evidence of increased centrally enhanced bladder compliance with ageing in a mouse model

2014

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ObjectiveTo test the hypothesis that ageing is associated with increasing neurogenic enhancement of bladder filling compliance. Materials and MethodsFemale B6 mice (aged 2, 12, 22 and 26 months) underwent cystometry while alive and immediately after death. Bladder compliance was calculated from pressure-time data. Pressure data were transformed using Fast Fourier Transform to obtain power spectra of bladder pressure variations attributable to contractile activity during filling in both alive and dead mice. A cut-off frequency (CF) was determined for each mouse, above which any power content would be primarily neurogenic. Compliance and power spectra results were compared among age groups, and correlations sought. ResultsA reversible loss of bladder compliance and non-voiding contractile (NVC) activity followed abolition of voiding reflexes in female colony mice in all age groups. Bladder filling compliance increased with age in urethane-anaesthetised and post-mortem conditions, and more so in the former. Power below the CF did not significantly vary with age. Neurogenic power increased with age, and significantly correlated with compliance. ConclusionsAn increase in neurogenic power during filling accompanies increased centrally mediated compliance enhancement with age. A bladder control model in which brain processes related to micturition may compensate for age-associated changes; thereby preserving voiding function is suggested. Urinary dysfunction could be viewed as the result of homeostatic failure rather than strictly end-organ pathology.

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“…25 Corresponding contractions (as reflected by changes in intravesical pressure) can be observed in isolated perfused bladders 8,26 and in intact bladders during cystometry, even in humans. 27 The difficulty in observing such contractions during cystometry in the human bladder may be explained by their lack of coordination-some units are contracting when others are relaxing-and no consistent change in intravesical pressure is recorded. However, in isolated bladder preparations from patients with DO, there seems to be increased coordination leading to larger amplitude contractions, 25 possibly reflecting changes in intercellular communication.…”

Section: Intercellular Communicationmentioning

confidence: 99%

Detrusor myocyte activity and afferent signaling

Andersson

2009

Neurourology and Urodynamics

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Aims: To discuss (1) mechanisms involved in the generation and control of myocyte contractions and consequent afferent nerve activity and (2) these mechanisms as targets for drugs aimed for treatment of overactive bladder (OAB) symptoms and detrusor overactivity (DO). Methods: Literature review of myocyte activation, bladder afferent nerves, mediators in the bladder, and translational aspects of the findings. Results: During bladder filling, there is normally no parasympathetic outflow from the spinal cord. Despite this, the bladder develops tone during filling and also exhibits non-synchronized local contractions and relaxations that are caused by a basal myogenic mechanical activity that may be reinforced by release of, for example, acetylcholine from non-neuronal and/or neuronal sources or local mediators, such as prostaglandins and endothelins. It is suggested that these spontaneous contractions are able to generate activity in afferent nerves (''afferent noise'') that may contribute to DO and OAB. Conclusions: Spontaneous bladder myocyte contractions and factors that are able to modulate them, as well as the consequent afferent nerve activity, may be targets for drugs meant for treatment of OAB/DO. Neurourol.

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Localized contractions in the normal human bladder and in urinary urgency

Cited by 130 publications

References 13 publications

Conscious voiding during bladder obstruction in guinea pigs correlates with contractile activity of isolated bladders

Conscious voiding during bladder obstruction in guinea pigs correlates with contractile activity of isolated bladders

Evidence of increased centrally enhanced bladder compliance with ageing in a mouse model

Detrusor myocyte activity and afferent signaling

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