Localized fibrous tumors of the pleura: clinical and surgical evaluation

Altınok, Tamer; Topçu, Salih; Taştepe, Abdullah İrfan; Yazıcı, Ülkü; Çetin, Güven

doi:10.1016/s0003-4975(03)00663-5

Cited by 36 publications

(29 citation statements)

References 13 publications

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“…Only 5% of neoplasms that arise from the pleura are SFTP and have been reported between the ages of 5 and 87; the incidence is only 2.8 cases per 100,000 (7,8).…”

Section: Discussionmentioning

confidence: 99%

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An unusual pathology with an undefined etiology:solitary fibrous tumors of the pleura

et al. 2016

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IntroductionPrimary tumors of the pleura are classified as diffuse and solitary. The solitary form was thought to be a form of mesothelioma and received different names such as localized mesothelioma, subpleural fibroma, benign mesothelioma, and subserous fibroma (1,2). It is recognized that the solitary fibrous tumor of the pleura (SFTP), which is rare and grows slowly, originates from mesenchymal cells of the submesothelial tissue of the pleura (3,4). No reports have demonstrated a correlation between SFTP and exposure to asbestos or any other carcinogens (5,6). Over 80% of these tumors are benign (1,4,7). They mostly appear between the 4th and 7th decades of life, half of them are asymptomatic, and they manifest as rounded, homogeneous masses with smooth margins on routine radiograms (8,9). Preoperative diagnosis is difficult because of nonspecific radiographic findings, and complete resection is the best prognostic factor (10-13).The aim of the present study was to identify any common or remarkable etiological factor or any biochemical abnormality or clinical presentation of SFTP, as well as to examine the best appropriate surgical approach and the results of long-term follow-up, and to compare these parameters with those reported in the literature. Materials and methodsBetween January 2001 and October 2014 the clinical and long-term follow-up records of 14 patients who had had surgery for SFTP were reviewed retrospectively. Common etiological factors, diagnostic procedures, and the clinical courses and outcomes for these patients were evaluated. The diagnosis of SFTP was confirmed by histomorphologic and immunohistochemical staining with hematoxylin/ eosin, CD34, vimentin, and cytokeratin. Malignancy criteria were described by England et al. (14) as more than 4 mitoses per 10 high-power fields, the presence of necrosis, and nuclear crowding and overlapping, which was defined as high cellularity and nuclear atypia. When one or more of these criteria was found histologically, the fibrous tumor was categorized as malignant (2,4). The classification of staging was based on de Perrot et al. Background/aim:The aim of the present study was to evaluate the etiology and clinical and pathological behavior of solitary fibrous tumors of the pleura (SFTPs), as well as the most appropriate surgical approach and the results of long-term follow-up of this condition.Materials and methods: Clinical and long-term follow-up records of 14 patients who had surgery for SFTP between 2001 and 2014 were reviewed retrospectively. Etiological factors, diagnostic procedures, and clinical courses and outcomes for these patients were studied.Results: Of the 14 patients, 8 were male (57%) and 6 were female (43%) patients. The mean age was 54.14 ± 10.35 (41-75) years. There was no remarkable common etiological factor. Preoperative diagnosis was achieved only in 2 patients. Predominant symptoms were cough and chest pain. Complete resection was achieved in all patients. Video-assisted thoracic surgery (VATS) was performed in 8 patients. All ...

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“…Only 5% of neoplasms that arise from the pleura are SFTP and have been reported between the ages of 5 and 87; the incidence is only 2.8 cases per 100,000 (7,8).…”

Section: Discussionmentioning

confidence: 99%

“…Serous pleural effusion has been reported in a malignant group (7,10). Radiographic signs are nonspecific.…”

Section: Discussionmentioning

confidence: 99%

An unusual pathology with an undefined etiology:solitary fibrous tumors of the pleura

et al. 2016

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“…The most important prognostic factor in treating SFTs is treatment with a complete resection (18,19). Due to the high probability of late recurrence, long-term follow-ups are required (18).…”

Section: Discussionmentioning

confidence: 99%

Solitary ﬁbrous tumor of the salivary gland: A case report

et al. 2015

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Abstract. Solitary fibrous tumors (SFTs) are rare soft-tissue tumors of mesenchymal origin. Occasionally, these lesions have been indicated to associate with the salivary glands. Through the analysis of magnetic resonance imaging sequences, the present study reports a case of a solitary salivary gland lesion, demonstrating a well-circumscribed, soft-tissue tumor with marked signal changes and homogenous enhancement. SFT should be considered as a differential diagnosis when a solid mass exhibiting hypointensity on T1-weighted images and hyperintensity on T2-weighted images has been detected in the salivary gland. Due to the potentially malignant nature of SFTs, it is necessary for radiologists to improve their understanding of such lesions.

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“…Several previous studies suggesting malignant transformation of SFT are summarized in Table. In cases 2 and 3, although most regions of the primary tumors were benign, each contained a malignant portion, suggesting malignant transformation within a benign tumor (8). Cases 6, 7 and 9 involved the recurrence of a benign tumor following curative resection of the primary tumor before subsequent malignant transformation (9-11), cases 1, 4, 5, 8 and 10 involved malignant recurrence without a preceding benign tumor (8,10,(12)(13)(14) and cases 4, 7 and 9 involved malignant transformation more than 10 years after initial surgery to treat the primary benign tumor (8,10,11). Therefore, although the malignant transformation of SFTP has been reported, transformation occurring after more than 10 years of follow-up without curative surgery is very rare.…”

Section: Discussionmentioning

confidence: 99%

Solitary Fibrous Tumor with Rapid Progression after 16 Years' Follow Up

et al. 2014

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A 79-year-old woman was admitted to our hospital for an investigation of a large 13-cm tumor in the chest and treatment for dyspnea in January 2010. The tumor had been observed on chest X-rays since 1992. It had measured 7 cm in 2008, then started to grow rapidly. Further investigations revealed that it was a malignant solitary fibrous tumor that was strongly suspected to have transformed from a benign to malignant state. Resection was not possible, and the patient died one month later. Benign solitary fibrous tumors of the pleura may become malignant during long-term follow-up. All suspected or proven solitary fibrous tumors of the pleura should be resected.

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Localized fibrous tumors of the pleura: clinical and surgical evaluation

Cited by 36 publications

References 13 publications

An unusual pathology with an undefined etiology:solitary fibrous tumors of the pleura

An unusual pathology with an undefined etiology:solitary fibrous tumors of the pleura

Solitary ﬁbrous tumor of the salivary gland: A case report

Solitary Fibrous Tumor with Rapid Progression after 16 Years' Follow Up

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