Localized Ground Glass Opacities With Multiple Pulmonary Small Cysts in Adult T-cell Leukemia or Lymphoma

Sakashita, Aya; Ashizawa, Kazuto; Minami, Kazunori; Fukuda, Toshio; Fukuda, Minoru; Abe, Kuniko; Hayashi, Tomayoshi; Uetani, Masataka

doi:10.1097/rti.0b013e3181c2f23d

Cited by 5 publications

(2 citation statements)

References 10 publications

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“…ATLL involving the lung can have multiple manifestations. These include nodules, acute pneumonitis, calcification, ground glass opacities, respiratory failure, and tracheal stenosis . The patient in this report had bilateral diffuse interstitial infiltrates in the lungs, which was unusual.…”

Section: Discussionmentioning

confidence: 59%

Cytological diagnosis of adult T‐cell leukemia/lymphoma in sputum

Jia

Liu

Axiotis

2016

Diagnostic Cytopathology

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Adult T-cell leukemia/lymphoma (ATLL) is a rare and often aggressive T-cell leukemia/lymphoma that has been linked to infection by the human T-cell lymphotropic virus type 1 (HTLV-1). ATLL can involve multiple organs including the respiratory airway. A 53-year-old Trinidadian woman presented with productive cough and progressive shortness of breath. Her past medical history included duodenal strongyloidosis, skin rash, and hypercalcemia. Radiological studies showed increased interstitial markings. Sputum cytology showed atypical pleomorphic, small-to-medium-sized, lobated lymphocytes with irregular and hyperchromatic nuclei resembling "flower cells" which were CD3±/CD20- by immunocytochemistry. A lung biopsy showed interstitial, peribronchiolar, and subpleural infiltration by a CD3±/CD25± atypical lymphocytic infiltrate. Together with peripheral blood findings and positive HTLV-1 serology, the diagnosis of ATLL was made. We suggest that sputum evaluation in patients with ATLL risk factors can be diagnostic.

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Section: Discussionmentioning

confidence: 59%

Cytological diagnosis of adult T‐cell leukemia/lymphoma in sputum

Jia

Liu

Axiotis

2016

Diagnostic Cytopathology

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“…Sakashita et al [ 25 ] described a case of acute T-cell lymphoma in which there was an alloy wheel appearance with a large cyst in the center of the ground-glass opacities surrounded peripherally by smaller clustered cysts from a combination of check valve effect and traction bronchiolectasis.…”

Section: Cystic Lung Diseasementioning

confidence: 99%

Pathologic and Radiologic Correlation of Adult Cystic Lung Disease: A Comprehensive Review

Boddu

Parimi

Taddonio

et al. 2017

Pathology Research International

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The presence of pulmonary parenchymal cysts on computed tomography (CT) imaging presents a significant diagnostic challenge. The diverse range of possible etiologies can usually be differentiated based on the clinical setting and radiologic features. In fact, the advent of high-resolution CT has facilitated making a diagnosis solely on analysis of CT image patterns, thus averting the need for a biopsy. While it is possible to make a fairly specific diagnosis during early stages of disease evolution by its characteristic radiological presentation, distinct features may progress to temporally converge into relatively nonspecific radiologic presentations sometimes necessitating histological examination to make a diagnosis. The aim of this review study is to provide both the pathologist and the radiologist with an overview of the diseases most commonly associated with cystic lung lesions primarily in adults by illustration and description of pathologic and radiologic features of each entity. Brief descriptions and characteristic radiologic features of the various disease entities are included and illustrative examples are provided for the common majority of them. In this article, we also classify pulmonary cystic disease with an emphasis on the pathophysiology behind cyst formation in an attempt to elucidate the characteristics of similar cystic appearances seen in various disease entities.

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