Localized leishmaniasis treated with intralesional meglumine antimoniate

Villela-Segura, Uriel; Proy‐Trujillo, Héctor; Ilizaliturri‐Flores, Ixtabay; Leal‐Ascencio, Victor Javier; Eljure‐López, Nixma

doi:10.1111/ddg.14165

Cited by 2 publications

(2 citation statements)

References 11 publications

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“…Die Wirksamkeit der topischen Behandlung mit Paromomycin 15% und Methylbenzethoniumchlorit 12% ist nur für L. major belegt. [2][3][4][5][6][7] Ein Hyperthermiegerät stand uns nicht zur Verfügung und die Umsetzung einer PDT war den Eltern nicht zu vermitteln. In der deutschsprachigen Leitlinie von 2011 werden als Therapie der ersten Wahl bei L.-tropica-Infektionen Azole empfohlen.…”

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Erfolgreiche Therapie einer komplexen kutanen Leishmaniose (L. tropica) bei einem 3‐jährigen syrischen Jungen mit Miltefosin

Golle,

Sunderkötter,

Ehrenreich

et al. 2024

J Deutsche Derma Gesell

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Erfolgreiche Therapie einer komplexen kutanen Leishmaniose (L. tropica) bei einem 3‐jährigen syrischen Jungen mit Miltefosin

Golle,

Sunderkötter,

Ehrenreich

et al. 2024

J Deutsche Derma Gesell

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“…The efficacy of topical treatment with paromomycin 15% and methylbenzethonium chlorite 12% has only been proven for L. major. [2][3][4][5][6][7] We had no access to a hyperthermia device and the implementation of PDT could not be communicated to the parents. In the Germanlanguage guideline of 2011, azoles are recommended as first-line therapy for L. tropica infections.…”

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confidence: 99%

Successful treatment of complex cutaneous leishmaniasis (L. tropica) in a 3‐year‐old Syrian boy with miltefosine

Golle,

Sunderkötter,

Ehrenreich

et al. 2024

J Deutsche Derma Gesell

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Complex cutaneous leishmaniasis, children, leishmania tropica, miltefosine, OWCL Dear Editors, A 3-year-old Syrian boy presented with ulcerating plaques on the face that had been present for about 8 months. There were two confluent, nodular papules measuring approximately 3 × 7 cm on the left cheek extending to the corner of the mouth with a central crusty ulceration measuring approximately 1 cm (Figure 1a) and an erythematous nodule the size of a hazelnut on the right earlobe with a crusty, flat ulceration (Figure 1b). An accompanying ipsilateral cervical lymph node swelling was also present. Differential blood count and inflammation tests showed no pathological findings. On suspicion of leishmaniasis and to exclude a deep bacterial or mycotic infection, in particular atypical mycobacteriosis or cat scratch disease, we took three skin biopsies for histological, microbiological, and molecular biological diagnostics. In the reference laboratory of the Bernhard Nocht Institute (Hamburg), no Leishmania could be cultivated from the native material, but histologically, plasma cell-rich granulomas were found under a pseudocarcinomatous epidermal hyperplasia without detectable intracellular parasites. Molecular biological testing of formalin-fixed material provided PCR evidence of Leishmania spp. (L. major/tropica/mexicana) and sequencing of the parasitic cytochrome B gene produced a 100% match with L. tropica. We treated with 2 mg/kg body weight (bw)/day miltefosine p.o. (here: 20 kg bw, 40 mg) in two single doses. A response was observed after 4 weeks. The ulcers shrank and the nodules flattened. At this time, the treatment could therefore have been discontinued, but it was mistakenly maintained due to an erythematous lesion at the corner of the mouth that was believed to still be active. Three months after the start of treatment there was

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Localized leishmaniasis treated with intralesional meglumine antimoniate

Cited by 2 publications

References 11 publications

Erfolgreiche Therapie einer komplexen kutanen Leishmaniose (L. tropica) bei einem 3‐jährigen syrischen Jungen mit Miltefosin

Erfolgreiche Therapie einer komplexen kutanen Leishmaniose (L. tropica) bei einem 3‐jährigen syrischen Jungen mit Miltefosin

Successful treatment of complex cutaneous leishmaniasis (L. tropica) in a 3‐year‐old Syrian boy with miltefosine

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