Localized mucormycosis following intramuscular corticosteroid. Case report and review of the literature

Jain, Jitender; Markowitz, Arnold J.; Khilanani, Prem V.; Lauter, Carl B.

doi:10.1097/00000441-197803000-00013

Cited by 64 publications

(34 citation statements)

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“…This possibility, and the importance of the skin as a barrier against fungal invasion, are sustained by other publications. Cases of mucormycosis have been reported after minor skin trauma [ll], intramuscular injection [5], and after the use of contaminated commercial elastic dressings [4]. We assume that fungal colonization in our patient occurred during transplantation, because of the early onset of the disease and massive involvement of the renal graft.…”

Section: Discussionmentioning

confidence: 88%

Mucormycosis of the renal allograft: case report and review of the literature

Chkhotua¹,

Yussim²,

Sobolev³

et al. 2001

Transplant Int

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Fungal infection is an uncommon complication after renal transplantation. We describe a rare form of mucormycosis in the renal graft. Our method was to review chart data and to perform medline searches. The patient was a 42-yearold man who underwent living-unrelated kidney transplantation in Egypt and returned to Israel on POD 8. Within the ensuing 4 weeks he experienced acute rejection which responded to treatment with steroids. Few days after discharge he was readmitted because of fever and graft dysfunction. An infected large perigraft collection was drained, but the patient became anuric and septic. Kidney biopsy showed infarcted necrotic tissue infiltrated by fungi which grew Mucur species. Despite initial improvement following graft nephrectomy and antifungal treatment the patient died of sepsis. Literature review revealed only three additional cases of graft infection due to Mucorales. We conclude that Renal graft infection due to Mucorales is an extremely rare and potentially lethal complication. Living unrelated donation in third world countries might be a possible risk factor. Fungal colonization may occur during transplantation. A high index of suspicion, leading to early diagnosis and initiation of antifungal treatment, in addition to graft nephrectomy, are keys to a more favorable outcome.

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Section: Discussionmentioning

confidence: 88%

Mucormycosis of the renal allograft: case report and review of the literature

Chkhotua¹,

Yussim²,

Sobolev³

et al. 2001

Transplant Int

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“…Traumatic implantation of spores in dirt has been seen in a number of patients (6,9,66,77,93,171,178,207,210,276,280,309,342,350,453). Needlestick exposures have been implicated in zygomycotic infections occurring at the site of medicine injection (77,158,215,361,474), catheter insertion sites (160,234,237,262,332), injection sites for illicit drug use (7,163,189,205,365,401,426,465,476,514), and tattooing (357). Insect bites or stings have also been implicated in disease transmission in cases of cutaneous and subcutaneous zygomycosis (33,152,159,199,203,233,372,494).…”

Section: Modes Of Transmissionmentioning

confidence: 99%

Zygomycetes in Human Disease

Ribes¹,

Vanover-Sams²,

Baker³

2000

Clinical Microbiology Reviews

1,093

1,053

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“…Aspergillus paraspinal myositis developed after local steroid injections in another patient (112); a similar case involving Mucor spp. has also been reported in conjunction with receipt of a steroid injection (109). Most cases have involved immunosuppressed patients receiving steroids and/or cytotoxic therapy, or AIDS patients with low CD4 cell counts (106,112).…”

Section: Aspergillus Sppmentioning

confidence: 99%

Bacterial, Fungal, Parasitic, and Viral Myositis

2008

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SUMMARY Infectious myositis may be caused by a broad range of bacterial, fungal, parasitic, and viral agents. Infectious myositis is overall uncommon given the relative resistance of the musculature to infection. For example, inciting events, including trauma, surgery, or the presence of foreign bodies or devitalized tissue, are often present in cases of bacterial myositis. Bacterial causes are categorized by clinical presentation, anatomic location, and causative organisms into the categories of pyomyositis, psoas abscess, Staphylococcus aureus myositis, group A streptococcal necrotizing myositis, group B streptococcal myositis, clostridial gas gangrene, and nonclostridial myositis. Fungal myositis is rare and usually occurs among immunocompromised hosts. Parasitic myositis is most commonly a result of trichinosis or cystericercosis, but other protozoa or helminths may be involved. A parasitic cause of myositis is suggested by the travel history and presence of eosinophilia. Viruses may cause diffuse muscle involvement with clinical manifestations, such as benign acute myositis (most commonly due to influenza virus), pleurodynia (coxsackievirus B), acute rhabdomyolysis, or an immune-mediated polymyositis. The diagnosis of myositis is suggested by the clinical picture and radiologic imaging, and the etiologic agent is confirmed by microbiologic or serologic testing. Therapy is based on the clinical presentation and the underlying pathogen.

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Localized mucormycosis following intramuscular corticosteroid. Case report and review of the literature

Cited by 64 publications

References 0 publications

Mucormycosis of the renal allograft: case report and review of the literature

Mucormycosis of the renal allograft: case report and review of the literature

Zygomycetes in Human Disease

Bacterial, Fungal, Parasitic, and Viral Myositis

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