Localized non-Hodgkin lymphoma involving the thyroid gland

Ha, Chul S.; Shadle, Kathleen M.; Medeiros, L. Jeffrey; Wilder, Richard B.; Hess, Annika; Cabanillas, F; Cox, James D.

doi:10.1002/1097-0142(20010215)91:4<629::aid-cncr1045>3.0.co;2-q

Cited by 106 publications

(63 citation statements)

References 27 publications

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“…Other rare subtypes are follicular lymphoma and Burkitt's lymphoma. 2 The underlying pathogenesis of primary thyroid lymphoma remains obscure. The thyroid gland contains no native lymphoid tissue.…”

Section: Discussionmentioning

confidence: 99%

“…1 Among the B-cell type NHLs, the most common type is DLBCL, either associated or unassociated with Mucosa-Associated Lymphoid Tissue (MALT) lymphoma (MALToma), Follicular lymphoma, Burkitt lymphoma (rare). 2 It usually occurs in elderly females and has been associated with Hashimoto's Thyroiditis (HT) and prior therapeutic irradiation of the thyroid bed. Here, we discuss these two rare cases of Primary Thyroid Lymphoma (PTL) recognized on Fine Needle Aspiration Cytology (FNAC) and immunocytochemistry which not only helped in timely but also accurate diagnosis of this disease as the prognosis and therapeutic protocol for these patients largely depends on the stage of the lymphoma so early diagnosis and accurate staging are vitally important.…”

Section: Introductionmentioning

confidence: 99%

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Primary thyroid lymphoma: a comprehensive summary of two cases

et al. 2015

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<p class="abstract"><span lang="EN-US">Thyroid lymphoma occurs rarely; constituting approximately 1-5% of all thyroid malignancies. Two cases of thyroid lymphoma are presented herewith. Both the patients were elderly females who presented with a rapidly enlarging anterior neck mass without cervical lymphadenopathy, leading to compressive symptoms like dysphagia, stridor and dyspnoea. Thyroid lymphoma is a great diagnostic and therapeutic challenge which requires high clinical suspicion with rapid and accurate diagnostic modalities to detect it as early recognition of this rare malignancy can lead to timely intervention and avoid morbidity associated with extensive surgery as chemotherapy and radiation are the mainstays of its treatment.</span></p>

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Primary thyroid lymphoma: a comprehensive summary of two cases

et al. 2015

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“…Malignant lymphomas of the thyroid gland are rare, accounting for 2-8 % of all malignant tumors of the thyroid gland [1][2][3], and 2.5-7 % of all extranodal nonHodgkin lymphomas [4][5][6]. Diffuse large B-cell lymphoma (DLBCL) is the most common, accounting for 60-85 % of the cases [1].…”

Section: Introductionmentioning

confidence: 99%

A Case of Advanced Primary Thyroid Double-Hit B Cell Lymphoma in Which Complete Remission has been Maintained After High-Dose Chemotherapy and Autologous Peripheral Blood Stem Cell Transplantation Performed During the Second Remission, with a Review of the Literature

Sekiguchi

Shimada

Imai

et al. 2014

Indian J Hematol Blood Transfus

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“…Tüm tiroid malignitelerinin %5'ini; nonHodgkin ekstranodal lenfomaların %3'ünü oluşturur. Sıklıkla B hücre kökenli mukoza ilişkili lenfoid doku (MALT) lenfomalardır (1)(2)(3)(4).…”

Section: Introductionunclassified

“…Seyrek rastlanmasına rağmen, tedavinin diğer tiroid karsinomlarından çok farklı olması nedeniyle doğru tanı konulması önemlidir. Klinik başvuru sıklıkla hızlı büyüyen boyun kitlesi nedeniyledir (1,4). Otoimmün tiroidit varlığı, primer tiroid lenfoması için önemli bir risk faktörüdür (6,7 Hastaya evreleme amaçlı çekilen PET-CT sonucunda herhangi bir odakta FDG tutulumu izlenmedi.…”

Section: Introductionunclassified

Primary thyroid lymphoma: mucosa associated lymphoid tissue lymphoma case

Alabalık¹,

Keleş²,

Türkçü³

et al. 2014

Gaziantep Med J

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Primary thyroid lymphomas are lymphomas which are localized only to thyroid gland or thyroid gland and surrounding lymph nodes. Frequently these are mucosa associated lymphoid tissue (MALT) lymphomas with B cell origin. Our case is a 78-year-old female patient who admitted with a neck mass and had been operated with the suspicion of malignancy. Histopathological examination revealed diffuse proliferation of atypical lymphoid cells that consists of small to medium sized cells, with irregular nuclear contours, some of which resemble centrocytes. Immunohistochemical staining was positive for CD20, CD79alpha, CD43, and lambda while negative for CD3, CD30, CD15, bcl-2, bcl-6, CD68, CD138, CD5, and CD10. With these finding, the case was considered as "primary thyroid MALT lymphoma". Thyroid MALT lymphomas are characterized with the presence of atypical lymphocytes that originate from the marginal zones of lymhoid follicles. Immunohistochemically, while these lymphomas express the B cell associated antibodies (CD20, CD22, CD79a), conversely CD5, CD10, and CD3 expressions are not seen. Keywords: CD20; MALT lymphoma; thyroid Özet Primer tiroid lenfoması, sadece tiroidi ya da tiroid ve bölgesel lenf bezlerini tutan lenfomadır. Sıklıkla B hücre kökenli mukoza ilişkili lenfoid doku (MALT) lenfomalardır. Vakamız boyunda kitle nedeniyle başvuran, malignite kuşkusuyla opere olmuş 78 yaşında kadın hastadır. Histopatolojik incelemede, küçük-orta boyda, düzensiz nükleer sınırlı, bir kısmı sentrositlere benzeyen hücrelerden oluşan diffüz atipik lenfoid hücre infiltrasyonu izlendi. İmmünohistokimyasal olarak CD20, CD79alfa, CD43 ve lambda pozitif, CD3, CD30, CD15, bcl-2, bcl-6, CD68, CD138, CD5 ve CD10 negatif boyandı ve vaka "primer tiroid MALT lenfoması" olarak değerlendirildi. Tiroid MALT lenfomaları lenfoid foliküllerin marjinal zonlarından köken alana atipik lenfositlerin varlığı ile karakterizedir. İmmünohistokimyasal olarak B hücre ilişkili antikorları (CD20, CD22, CD79a) eksprese ederken CD5, CD10 ve CD3 ekspresyonu görülmez. Anahtar kelimeler: CD20; MALT lenfoma; tiroid Giriş Primer tiroid lenfoması, sadece tiroidi ya da tiroid ve bölgesel lenf bezlerini tutan lenfomadır. Seyrek görülür. Tüm tiroid malignitelerinin %5'ini; nonHodgkin ekstranodal lenfomaların %3'ünü oluşturur. Sıklıkla B hücre kökenli mukoza ilişkili lenfoid doku (MALT) lenfomalardır (1-4).

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Localized non-Hodgkin lymphoma involving the thyroid gland

Cited by 106 publications

References 27 publications

Primary thyroid lymphoma: a comprehensive summary of two cases

Primary thyroid lymphoma: a comprehensive summary of two cases

A Case of Advanced Primary Thyroid Double-Hit B Cell Lymphoma in Which Complete Remission has been Maintained After High-Dose Chemotherapy and Autologous Peripheral Blood Stem Cell Transplantation Performed During the Second Remission, with a Review of the Literature

Primary thyroid lymphoma: mucosa associated lymphoid tissue lymphoma case

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