Localized pemphigus vegetans of the nose and lips: A classic case of a rare entity

Chronic Painful Vegetative Plaques on the Buttocks: Answer

“…Direct immunofluorescence shows intercellular deposition of IgG and C3. 4,6,9 Serologic studies with enzyme-linked immunosorbent assay typically show IgG antibodies against desmoglein 1 and 3. Some patients may demonstrate IgG and/or IgA antibodies against desmocollin 1 and 2, and IgG antibodies against periplakin.…”

A visually striking case of centrofacial destructive ulceration and desquamative gingivitis from chronic cocaine use

“…To the Editor: We appreciated the article from Magro et al, 1 which described pemphigus vegetans (PVeg) limited to the nose and lips, allowing us to introduce another differential diagnosis: cocaine-induced midline destructive lesion (CIMDL). PVeg is a rare variant of the autoimmune vesiculobullous disease pemphigus vulgaris, characterized by vegetative plaques in intertriginous areas and oral mucosa.…”

“…2 Nasolabial PVeg is rare, with 6 reported cases. 1 PVeg should be considered in the differential diagnosis with CIMDL. CIMDL is a consequence of intranasal inhalation of cocaine and can lead to inflammation, ulceration, necrosis, and perforation of nasolabial structures.…”