Localized primary malignant lymphoma of bone

Dubey, Praveen; Ha, Chul S.; Besa, Pablo; Fuller, Lillian M.; Cabanillas, Fernando; Murray, John A.; Hess, Mark A.; Cox, James D.

doi:10.1016/s0360-3016(97)00106-5

Cited by 105 publications

(78 citation statements)

References 31 publications

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“…The most frequent presentation of PBL is bone pain or a palpable mass or both (3,7,12). When the spine bones are involved back pain is the most common symptom.…”

Section: Undabeitia J Et Al: Primary Bone Non-hodgkin Lymphoma Of Thmentioning

confidence: 99%

“…While bone involvement is a common complication in advanced stage lymphomas, primary bone lymphoma (PBL) is a rare disease, accounting for approximately 3% of malignant bone tumours, less than 2% of all lymphomas and less than 5% of extranodal lymphomas in adults (3,5,7,12,16,19,21). The most common locations for PBL are reported to be the femur or the pelvis (50%) and the long bones of the upper limbs (20%) with the remaining 30% occurring in other locations such as the ribs, mandible or scapula (14,16).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Primary bone non-hodgkin lymphoma of the cervical spine. case report and review.

Undabeitia¹,

Noboa²,

Boix³

et al. 2013

Turkish Neurosurgery

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Primary bone lymphomas (PBL) account for approximately 3% of all malignant tumors and are commonly found in the femur or pelvis. Only 1.7% of the PBLs are found in the spine. We report the case of a 73-year-old male complaining of cervical pain with progressive loss of strength and frequent falls. The MRI showed invasion of the fourth cervical vertebra and an infiltrating prevertebral mass. A C4 corpectomy was performed. The pathology exam revealed a diffuse large B-cell lymphoma. Due to the previous condition of the patient only radiotherapy treatment was applied. PBL arising from the cervical spine is an exceptional event. The low incidence of this condition and its unspecific radiological features make the diagnosis challenging for the clinician. When neurological deficit appears, early surgery for decompression is indicated, followed by local radiotherapy and systemic chemotherapy. KEywoRds: Non Hodgkin lymphoma, Cervical vertebrae, Diffuse large B-cell lymphoma ÖZPrimer kemik lenfomaları (PKL) tüm malign tümörlerin yaklaşık %3'ünü oluşturur ve sıklıkla femur veya pelviste bulunur. PKL'lerin sadece %1,7'si omurgada bulunur. Servikal ağrı, giderek azalan güç ve sık düşmelerden yakınan 73 yaşında bir erkek olguyu sunuyoruz. MRG dördüncü servikal vertebra invazyonu ve bir infiltratif prevertebral kitle gösterdi. C4 korpektomi yapıldı. Patoloji incelemesi difüz büyük B hücreli lenfoma olarak rapor edildi. Hastanın önceki durumu nedeniyle sadece radyoterapi tedavisi uygulandı. Servikal omurgadan köken alan PKL çok nadirdir. Bu hastalığın insidansının düşüklüğü ve spesifik olmayan radyolojik özellikleri tanıyı klinisyen için zor hale getirir. Nörolojik defisit belirdiğinde, dekompresyon için erken cerrahi endikedir ve sonrasında lokal radyoterapi ve sistemik kemoterapi uygulanır.ANAHTAR sÖZCÜKLER: Non Hodgkin lenfoma, Servikal vertebra, Diffüz büyük B hücreli lenfoma

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“…The most frequent presentation of PBL is bone pain or a palpable mass or both (3,7,12). When the spine bones are involved back pain is the most common symptom.…”

Section: Undabeitia J Et Al: Primary Bone Non-hodgkin Lymphoma Of Thmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Primary bone non-hodgkin lymphoma of the cervical spine. case report and review.

Undabeitia¹,

Noboa²,

Boix³

et al. 2013

Turkish Neurosurgery

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“…Primary non-Hodgkin's lymphoma of bone (PNHLB) is a rare disease comprising approximately 4 to 5% of extranodal lymphomas (1,2) and Ͻ1% of all non-Hodgkin's lymphomas (1). Clinically defined as "lymphoma presenting in an osseous site with no evidence of disease elsewhere for at least six months after diagnosis," it was first established as a clinical entity in 1939 (3).…”

mentioning

confidence: 99%

An Immunophenotypic and Molecular Study of Primary Large B-Cell Lymphoma of Bone

et al. 2001

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“…Several studies suggest that the combination of chemotherapy and radiotherapy is the best treatment, as a consequence of which resection or amputation can be prevented. 4,17,18 In this cohort the overall 5-year survival was 61%. This is surprisingly high when the heterogeneous treatment schedules over the years of the study and the inclusion of stage IV patients are taken into account.…”

Section: Discussionmentioning

confidence: 67%

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1999

Leukemia

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A retrospective analysis of patients presenting with primary lymphoma of bone (PLB) was performed to determine clinical factors affecting prognosis in relation to histological subtype and treatment outcome. Data from 106 patients, presenting with a PLB between 1943 and 1996, were retrieved from the files of the Netherlands Committee on Bone Tumours and Leiden University Medical Centre. The lymphomas were reclassified according to the REAL and updated Kiel classification. The clinical presentation, survival and prognostic factors were investigated. Sixty patients had sufficient clinical information and adequate follow-up to be included in the study. All 33 PLB that could be immunophenotyped were of B cell origin. According to the REAL classification, most PLB were large (B) cell lymphomas (92%) and according to the Kiel classification 45% of the tumours were centroblastic multilobated. PLB presented most often in the long bones (48%), with Ann Arbor stage I (46%), II (16%), IV (16%) and unknown (20%). Stage IV disease was exclusively caused by the presence of multiple bone lesions. Notwithstanding the heterogeneous treatment, the 5-year overall survival was 61%; 46% of patients were progression free at 5 years. Patients at presentation older than 60 had a worse overall survival (76% vs 37%, P ‫؍‬ 0.0002) and a worse progression-free period (58% vs 28%, P ‫؍‬ 0.0073). Patients with the immunoblastic subtype had a worse survival than the centroblastic mono/polymorphic subtype or the centroblastic multilobated subtype (P ‫؍‬ 0.015). Primary lymphoma of bone represents an uncommon bone tumour with a relatively homogeneous morphology and clinical behaviour. Compared to other aggressive lymphomas, PLB have a favourable prognosis.

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Localized primary malignant lymphoma of bone

Cited by 105 publications

References 31 publications

Primary bone non-hodgkin lymphoma of the cervical spine. case report and review.

Primary bone non-hodgkin lymphoma of the cervical spine. case report and review.

An Immunophenotypic and Molecular Study of Primary Large B-Cell Lymphoma of Bone

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