Localized scleroderma associated with progressing ischemic stroke

Kanzato, Naomi; Matsuzaki, Takashi; Komine, Yukihiro; Saito, Mineki; Saito, Akiko; Yoshio, Taku; Suehara, Masahito

doi:10.1016/s0022-510x(98)00267-6

Cited by 32 publications

(20 citation statements)

References 8 publications

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“…Seizures and headache were the most frequent conditions, and this finding is consistent with the data already reported in the literature (15)(16)(17)(18)(19)(20)(21)(22). Behavioral changes and learning disabilities have also been reported (23,24), while conditions such as stroke, transverse myelitis, and hemiparesis, which have been reported in adults (23,(25)(26)(27)(28), were not present. In our series, intraparenchymal abnormalities on MRI, vascular malformations, or CNS vasculitis represented one-third of these neurologic manifestations.…”

Section: Discussionsupporting

confidence: 90%

Localized scleroderma in childhood is not just a skin disease

Zulian

Vallongo

Woo

et al. 2005

Arthritis & Rheumatism

331

268

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Objective. Juvenile localized scleroderma is usually considered a disease that is confined to the skin and subcutaneous tissue. We studied the prevalence and clinical features of extracutaneous manifestations in a large cohort of children with juvenile localized scleroderma.Methods. Data from a multinational study on juvenile scleroderma was used for this in-depth study. Clinical features of patients with extracutaneous manifestations were compared with those of patients who had exclusively skin involvement.Results. Seven hundred fifty patients entered the study. One hundred sixty-eight patients (22.4%) presented with a total of 193 extracutaneous manifestations, as follows: articular (47.2%), neurologic (17.1%), vascular (9.3%), ocular (8.3%), gastrointestinal (6.2%), respiratory (2.6%), cardiac (1%), and renal (1%). Other autoimmune conditions were present in 7.3% of patients. Neurologic involvement consisted of epilepsy, central nervous system vasculitis, peripheral neuropathy, vascular malformations, headache, and neuroimaging abnormalities. Ocular manifestations were episcleritis, uveitis, xerophthalmia, glaucoma, and papilledema. In more than one-fourth of these children, articular, neurologic, and ocular involvements were unrelated to the site of skin lesions. Raynaud's phenomenon was reported in 16 patients. Respiratory involvement consisted essentially of restrictive lung disease. Gastrointestinal involvement was reported in 12 patients and consisted exclusively of gastroesophageal reflux. Thirty patients (4%) had multiple extracutaneous features, but systemic sclerosis (SSc) developed in only 1 patient. In patients with extracutaneous involvement, the prevalence of antinuclear antibodies and rheumatoid factor was significantly higher than that among patients with only skin involvement. However, Scl-70 and anticentromere, markers of SSc, were not significantly increased.Conclusion. Extracutaneous manifestations of juvenile localized scleroderma developed in almost onefourth of the children in this study. These extracutaneous manifestations often were unrelated to the site of the skin lesions and sometimes were associated with multiple organ involvement. The risk of developing SSc

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Section: Discussionsupporting

confidence: 90%

Localized scleroderma in childhood is not just a skin disease

Zulian

Vallongo

Woo

et al. 2005

Arthritis & Rheumatism

331

268

View full text Add to dashboard Cite

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“…We found the highest prevalence of ischemic heart disease among AIS admissions with SSc. This is consistent with prior case reports suggesting a higher incidence of vascular risk factors such as severe hypertension, chronic renal failure, or cerebral vasculitis [11,45,46]. Awareness and early treatment intervention of ischemic heart disease and hypertension may prevent AIS in these patients.…”

Section: Discussionsupporting

confidence: 92%

“…SSc is an autoimmune connective tissue disease characterized by microangiopathy and skin and visceral fibrosis and a close association with specific autoantibody patterns. While there are case reports of AIS and transient ischemic attack in patients with SSc [11,45,46], there are no epidemiological studies that examine the prevalence of SSc within AIS. We found that AIS admissions with SSc were more likely to be female and of White race.…”

Section: Discussionmentioning

confidence: 99%

The Prevalence of Systemic Diseases Associated with Dermatoses and Stroke in the United States: A Cross-Sectional Study

Kupetsky

Rincón²

2013

Dermatology

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Aims: To evaluate the prevalence of systemic diseases associated with dermatoses and conventional risk factors in patients with acute ischemic stroke (AIS). We hypothesized that conventional risk factors would not be overrepresented in AIS admissions of patients with dermatoses. Methods: Cross-sectional study. We ascertained admissions of AIS with and without the following: systemic lupus erythematosus (SLE), psoriasis (PSO), scleroderma (SSc), dermatomyositis (D-MS), bullous pemphigoid (BP), and Behçet's disease. Results: 6,454,877 admissions had a primary diagnosis of AIS of whom 34,345 had dermatoses. The prevalence of dermatoses within AIS was 0.5% (95% CI 0.32-0.55). Prevalent dermatoses at the time of AIS admission were SLE (63%), PSO (18%), SSc (12%), D-MS (4%), and BP (2%). There were no significant differences in the prevalence of traditional risk factors among dermatoses; however, these patients tended to be younger women. Hospital days of care (median 4, IQR 3-8, vs. 5, IQR 3-9, p = 0.005) and in-hospital mortality were lower (5 vs.7%, p = 0.05) for those admissions of AIS patients with dermatoses. Conclusions: The prevalence of systemic diseases associated with dermatoses is rare in admissions of patients with AIS. Traditional risk factors were not overrepresented in AIS admissions with dermatoses. In-hospital mortality and length of stay were significantly lower in admissions of patients with AIS and dermatoses.

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“…Epilepsy [8], [15••], [16], [18], [19•], [20][21][22][23][24][25][26][27][28] Headache dizziness [9], [16], [22], [23] Stroke [10] Oculomotor abnormalities [11], [13], [16], [26] Transverse myelitis [12] Hemiparesis [14], [19•], [23] Learning disabilities [14], [21] Vertigo [16] CNS abnormal imaging Calcifications [14], [15••], [16], [17•], [18], [20] Vascular abnormalities [14], [23], [28] White matter abnormalities (MRI) [9][10][11], [16], [17•], [18], [19•], [21], [22], [24], [25], …”

Section: Clinical Manifestations Studiesmentioning

confidence: 99%