Localized sequence-specific release of a chemopreventive agent and an anticancer drug in a time-controllable manner to enhance therapeutic efficacy

Pan, Wen; Lin, Kun; Huang, Chieh‐Cheng; Chiang, Wei Lun; Lin, Yi-Chun; Lin, Wei; Chuang, Er-Tuan; Chang, Yu-Lung; Sung, Hsing‐Wen

doi:10.1016/j.biomaterials.2016.06.008

Cited by 18 publications

(11 citation statements)

References 39 publications

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“…The results demonstrated that 10 nM 1,25(OH) 2 D 3 did not increase ROS production compared with control; however, when combined with ADM, ROS generation was increased in ATC cells. This finding has been previously demonstrated in breast cancer cell lines (29). In addition, the apoptotic cell rate in ATC cells was reduced following NAC addition in the two-drug combination group.…”

Section: Discussionsupporting

confidence: 86%

1,25‑dihydroxyvitamin D3 enhances the susceptibility of anaplastic thyroid cancer cells to adriamycin‑induced apoptosis by increasing the generation of reactive oxygen species

Zhang

Sun

et al. 2019

Mol Med Report

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Anaplastic thyroid cancer (ATC) is a very aggressive malignancy that is resistant to various types of chemotherapy in humans. Most patients with late-stage ATC cannot undergo surgery and receive chemotherapy drugs. The present study investigated the influence of 1,25-dihydroxyvitamin D 3 (1,25(OH) 2 D 3 ) pretreatment on adriamycin (ADM) chemotherapy efficacy in the 8305c and 8505c ATC cell lines. The apoptotic effects of ADM on ATC cells pretreated with 1,25(OH) 2 D 3 were evaluated. Cell viability was identified by using the Cell Counting Kit-8 assay. Apoptosis was assessed by flow cytometry and staining with Hoechst 33342. The expression of the apoptotic protein cleaved caspase-3 was tested with a colorimetric assay kit and by western blotting. Reactive oxygen species (ROS) generation was assessed with the antioxidant N-acetyl-L-cysteine (NAC) and the assay H 2 -DCFDA. In addition, ROS production could be reversed by NAC treatment. The present study demonstrated that 1,25(OH) 2 D 3 enhanced ADM-induced apoptosis in 8305c and 8505c cell lines. Furthermore, 1,25(OH) 2 D 3 improved the ADM-induced ROS production and expression of cleaved caspase-3. NAC treatment inhibited the expression of cleaved caspase-3 in ATC cells, and reduced apoptosis in cells that were pretreated with 1,25(OH) 2 D 3 and ADM. These results demonstrated that 1,25(OH) 2 D 3 may enhance ADM-induced apoptosis by increasing ROS generation in ATC cells.

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Section: Discussionsupporting

confidence: 86%

1,25‑dihydroxyvitamin D3 enhances the susceptibility of anaplastic thyroid cancer cells to adriamycin‑induced apoptosis by increasing the generation of reactive oxygen species

Zhang

Sun

et al. 2019

Mol Med Report

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“…The tumor microenvironment (TME), which is often featured with vascular abnormalities, high lactate levels, glucose deprivation, low pH values, and hypoxia 1–5 , is an important factor that largely affects the therapeutic outcomes in many conventional cancer therapies 6–11 . Moreover, it also been discovered that the unique features of TME may greatly limit the killing functions of cytotoxic T lymphocytes and promote the immunosuppression by multiple kinds of cells like myeloid-derived suppressor cells (MDSC), M2 tumor-associated macrophages (TAM), and regulatory T cells (Treg) within tumors, all of which are unfavorable for cancer treatment 12, 13 .…”

Section: Introductionmentioning

confidence: 99%

Hollow MnO2 as a tumor-microenvironment-responsive biodegradable nano-platform for combination therapy favoring antitumor immune responses

et al. 2017

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Herein, an intelligent biodegradable hollow manganese dioxide (H-MnO2) nano-platform is developed for not only tumor microenvironment (TME)-specific imaging and on-demand drug release, but also modulation of hypoxic TME to enhance cancer therapy, resulting in comprehensive effects favoring anti-tumor immune responses. With hollow structures, H-MnO2 nanoshells post modification with polyethylene glycol (PEG) could be co-loaded with a photodynamic agent chlorine e6 (Ce6), and a chemotherapy drug doxorubicin (DOX). The obtained H-MnO2-PEG/C&D would be dissociated under reduced pH within TME to release loaded therapeutic molecules, and in the meantime induce decomposition of tumor endogenous H2O2 to relieve tumor hypoxia. As a result, a remarkable in vivo synergistic therapeutic effect is achieved through the combined chemo-photodynamic therapy, which simultaneously triggers a series of anti-tumor immune responses. Its further combination with checkpoint-blockade therapy would lead to inhibition of tumors at distant sites, promising for tumor metastasis treatment.

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“…[ 20,21 ] The produced oxygen can enhance the efficiency of oncotherapy, including photodynamics therapy (PDT), sonodynamic therapy (SDT), radiotherapy (RT), starvation therapy, chemodynamic therapy (CDT), and immunotherapy. [ 22–25 ] Meanwhile, eliminating GSH efficaciously weakens the reactive oxygen species (ROS) scavenging effect, further strengthening PDT, SDT, and CDT. [ 26–28 ]…”

Section: Introductionmentioning

confidence: 99%

Hollow Mesoporous Manganese Oxides: Application in Cancer Diagnosis and Therapy

Qing

Liu

et al. 2022

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The precision, minimal invasiveness, and integration of diagnosis and treatment are critical factors for tumor treatment at the present. Although nanomedicine has shown the potential in tumor precision treatment, nanocarriers with high efficiency, excellent targeting, controlled release, and good biocompatibility still need to be further explored. Hollow mesoporous manganese oxides nanomaterials (HM‐MONs), as an efficient drug delivery carrier, have attracted substantial attention in applications of tumor diagnosis and therapy due to their unique properties, such as tumor microenvironment stimuli‐responsiveness, prominent catalytic activity, excellent biodegradation, and outstanding magnetic resonance imaging ability. The HM‐MONs can not only enhance the therapeutic efficiency but also realize multimodal diagnosis of tumors. Consequently, it is necessary to introduce applications based on HM‐MONs in cancer diagnosis and therapy. In this review, the representative progress of HM‐MONs in synthesis is discussed. Then, several promising applications in drug delivery, bio‐imaging, and bio‐detection are highlighted. Finally, the challenges and perspectives of the anticancer applications are summarized, which is expected to provide meaningful guidance on further research.

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Localized sequence-specific release of a chemopreventive agent and an anticancer drug in a time-controllable manner to enhance therapeutic efficacy

Cited by 18 publications

References 39 publications

1,25‑dihydroxyvitamin D3 enhances the susceptibility of anaplastic thyroid cancer cells to adriamycin‑induced apoptosis by increasing the generation of reactive oxygen species

1,25‑dihydroxyvitamin D3 enhances the susceptibility of anaplastic thyroid cancer cells to adriamycin‑induced apoptosis by increasing the generation of reactive oxygen species

Hollow MnO2 as a tumor-microenvironment-responsive biodegradable nano-platform for combination therapy favoring antitumor immune responses

Hollow Mesoporous Manganese Oxides: Application in Cancer Diagnosis and Therapy

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