Localized thigh swelling mimicking a neoplastic process: involvement of coxsackie virus type A21

Abstract

Dekel B, Yoeli R, Shulman L, Padeh S, Passwell JH. Localized thigh swelling mimicking a neoplastic process: involvement of coxsackie virus type A21. Acta P~diatr 2002; 91: 357-359. Stockholm. ISSN 0803-5253A 4-y-old girl was admitted because of a left leg limp with an isolated swollen upper thigh and normal muscle enzymes. A radioisotope scan showed increased uptake especially in the bone and soft tissue of the left thigh, while magnetic resonance imaging of that region demonstrated widespread oedema in striated muscle. On muscle biopsy perivascular in ltrates were demonstrated but muscle bres were not shown to be affected. Sequence analysis of reverse transcription-polymerase chain reaction ampli ed fragments from the 5'-non-coding region of human enteroviruses identi ed a local strain of coxsackie virus A21 in the muscle. Clinical symptomatology subsided with oral steroids. Conclusion:Local swelling mimicking a neoplasm may be related to infestation of coxsackie virus in muscle tissue.

Myeloma Xenograft Destruction by a Nonviral Vector Delivering Oncolytic Infectious Nucleic Acid

“…Eventually the viremic animals succumb to generalized myositis, although this side effect is probably an artifact of the SCID mouse model since immunocompetent animals are known to be resistant to CVA21 myositis, 26 experimental CVA21 infections in humans cause little more than a short lived upper respiratory tract infection, 27 and only one human case of localized CVA21 myositis has been reported. 28 It will be interesting also to test the approach in an immunocompetent syngeneic mouse model but to date we have not been able to identify a mouse tumor that responds to CVA21 oncolytic virotherapy. The idea that INA coding for an oncolytic virus could be used for cancer therapy was formally proposed by Sutton in a letter to the Lancet in 1991.…”

Coxsackievirus B3—Its Potential as an Oncolytic Virus

“…CVA21 is a naturally occurring enterovirus that can induce mild infections of the upper respiratory tract in humans, but also myositis [156][157][158]. The virus is one of the most studied OV.…”

Oncolytic Virotherapy for Multiple Myeloma: Past, Present, and Future

“…Although it is known to cause respiratory tract infections and myositis in humans [67, 68], its oncolytic potential has been proven in several cancer cell lines including MM [69, 70]. Intracellular adhesion molecule-1 (ICAM-1) and decay-accelerating factor are 2 receptors that are necessary for CVA21 infection and cell lysis, and both these are reported to be upregulated in cancer cells including MM in comparison to normal cells [69, 71].…”